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RETA

Reata Pharmaceuticals

$86.70

0.36 (0.42%)

06:53
02/20/19
02/20
06:53
02/20/19
06:53

Reata Pharmaceuticals reports 'positive' results from FSGS cohort of PHOENIX

Reata Pharmaceuticals announced positive, final results from the focal segmental glomerulosclerosis cohort of PHOENIX, a Phase 2 study of bardoxolone methyl in patients with rare forms of chronic kidney disease. Compared to baseline, bardoxolone significantly improved kidney function as measured by patients' estimated glomerular filtration rate at Week 12, which was the primary endpoint of the PHOENIX study. Patients treated with bardoxolone experienced a significant increase in eGFR of 7.8 mL/min/1.73 m2 at Week 12 compared to baseline. Reata collected historical eGFR data for 17 of the 18 patients, which demonstrated that these patients' kidney function was declining at an average annual rate of 2.6 mL/min/1.73 m2 prior to study entry. The observed 7.8 mL/min/1.73 m2 improvement after 12 weeks of treatment with bardoxolone represents a recovery of three years of average eGFR loss. With respect to safety, no treatment-related serious adverse events were reported, and the reported adverse events were generally mild to moderate in intensity. Overall, the PHOENIX trial studied 103 patients who had one of four rare forms of CKD, including autosomal dominant polycystic kidney disease, IgA nephropathy, type 1 diabetic CKD, and FSGS. Historical eGFR data collected from 91 of the 103 patients demonstrated that these patients' kidney function was declining at an average annual rate of 2.8 mL/min/1.73 m2 prior to study entry. After 12 weeks of once-daily, oral administration of bardoxolone, the mean change in eGFR from baseline across all four cohorts was 7.8 mL/min/1.73 m2. Notably, 88% of patients who reached Week 12 demonstrated an improvement in eGFR. Bardoxolone significantly reduced mean systolic blood pressure by 3.8 mmHg and mean diastolic blood pressure by 2.8 mmHg. Urinary albumin excretion was low upon study entry and remained unchanged by bardoxolone treatment. Bardoxolone was well-tolerated, with 89% of patients in PHOENIX completing treatment through Week 12, and no treatment-related serious adverse events were reported.

RETA Reata Pharmaceuticals
$86.70

0.36 (0.42%)

08/23/18
CANT
08/23/18
INITIATION
Target $90
CANT
Overweight
Reata Pharmaceuticals initiated with an Overweight at Cantor Fitzgerald
Cantor Fitzgerald analyst Charles Duncan last night started Reata Pharmaceuticals with an Overweight rating and $90 price target. The analyst believes the company's lead candidates bardoxolone and omaveloxolone have a novel mechanism of actio and applicability in several diseases characterized by mitochondrial dysfunction, oxidative stress and chronic inflammation/fibrosis.
09/26/18
SBSH
09/26/18
NO CHANGE
Target $185
SBSH
Buy
Citi sees 'very good entry point' for Reata Pharmaceuticals
Citi analyst Yigal Nochomovitz says he has more conviction in Reata Pharmaceuticals, his top SMID biotech pick, after the company announced final results from the IgA nephropathy and type 1 diabetic chronic kidney disease cohorts of PHOENIX, a Phase 2 study of bardoxolone methyl in patients with rare forms of CKD. He believes current share levels is a "very good entry point" and keeps a Buy rating on the shares with a $185 price target.
09/26/18
LTCO
09/26/18
NO CHANGE
Target $133
LTCO
Buy
Reata Pharmaceuticals price target raised to $133 from $102 at Ladenburg
Ladenburg Thalmann analyst Matthew Kaplan raised his price target for Reata Pharmaceuticals to $133 saying bardoxolone continues to consistently show improvement in kidney function in several rare forms of chronic kidney disease. The analyst continues to be impressed with the consistency of the efficacy results for bardoxolone and reiterates a Buy rating on Reata shares.
02/06/19
JEFF
02/06/19
NO CHANGE
JEFF
Jefferies highlights Karyopharm, Reata as stocks to focus on in 2019
Jefferies analyst Maury Raycroft highlights Karyopharm Therapeutics (KPTI) and Reata Pharmaceuticals (RETA) as two stocks to focus on in 2019. Karyopharm has important regulatory updates upcoming with an expected FDA panel for selinexor in penta-refractory multiple myeloma and then an FDA action date scheduled for April 6, Raycroft tells investors in a research note. And Reata is expected to report initial, awaited focal segmental glomerulosclerosis data in the first half of 2019 and then two pivotal readouts in the second half in Alport syndrome and Friedreich's ataxia, adds the analyst. He believes the current share weakness offers an "appealing entry point" for Karyopharm.

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