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PFE

Pfizer

$42.32

0.51 (1.22%)

, MKGAY

Merck KGaA

$0.00

(0.00%)

19:17
03/19/19
03/19
19:17
03/19/19
19:17

Pfizer, Merck KGaA discontinue Phase III JAVELIN Ovarian PARP study

Merck KGaA (MKGAY) and Pfizer Inc. (PFE) announced the discontinuation of the ongoing Phase III JAVELIN Ovarian PARP 100 study evaluating the efficacy and safety of avelumab in combination with chemotherapy followed by maintenance therapy of avelumab in combination with talazoparib, a poly polymerase inhibitor, versus an active comparator in treatment-naive patients with locally advanced or metastatic ovarian cancer. The alliance has notified health authorities and trial investigators of the decision to discontinue the trial. The decision was based on several emerging factors since the trial's initiation, including the previously announced interim results from JAVELIN Ovarian PARP 100. The alliance determined that the degree of benefit observed with avelumab in frontline ovarian cancer in that study does not support continuation of the JAVELIN Ovarian PARP 100 trial in an unselected patient population and emphasizes the need to better understand the role of immunotherapy in ovarian cancer. Additional factors include the rapidly changing treatment landscape and the approval of a PARP inhibitor in the frontline maintenance setting. The decision to discontinue the JAVELIN Ovarian PARP 100 trial was not made for safety reasons. The decision to discontinue the JAVELIN Ovarian PARP 100 trial does not impact the currently approved indications for avelumab or the remainder of the ongoing JAVELIN clinical development program. The program involves at least 30 clinical programs and more than 9,000 patients evaluated across more than 15 different tumor types, including breast, gastric/gastro-esophageal junction, and head and neck cancers, Merkel cell carcinoma, non-small cell lung cancer, and urothelial carcinoma.

PFE

Pfizer

$42.32

0.51 (1.22%)

MKGAY

Merck KGaA

$0.00

(0.00%)

  • 20

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PFE Pfizer
$42.32

0.51 (1.22%)

01/31/19
01/31/19
UPGRADE

Fly Intel: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Pfizer (PFE) upgraded to Outperform from Neutral at Credit Suisse and to Buy from Hold at Argus. 2. Tiffany (TIF) upgraded to Overweight from Neutral at Atlantic Equities with analyst Daniela Nedialkova saying the pullback has been largely driven by macro concerns while fundamentals of the brand are strong and preliminary FY19 guidance is conservative. 3. Scotts Miracle-Gro (SMG) upgraded to Neutral from Underweight at JPMorgan with analyst Jeffrey Zekauskas citing valuation. 4. Geron (GERN) upgraded to Buy from Neutral at B. Riley FBR with analyst George Zavoico saying he believes investors should focus on the pivotal Phase III trial of imetelstat. 5. Ralph Lauren (RL) upgraded to Outperform from Market Perform at Telsey Advisory with analyst Dana Telsey saying the company's improving sakes, combined with ongoing margin expansion, should bolster its earnings. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
02/20/19
SBSH
02/20/19
UPGRADE
Target $41
SBSH
Neutral
Pfizer resumed with a Neutral from Sell at Citi
Citi analyst Andrew Baum resumed coverage of Pfizer following a period of restriction and upgraded the shares to Neutral from Sell. He also boosted his price target for the shares to $41 from $37. The analyst says the recent pullback in the stock, along with the 5%-8% 2019-2021 consensus estimate reductions, gives him the opportunity to close his Sell rating. He believes management action on business development, cost saving or moves to better monetize Pfizer's Established Product business are likely near-term drivers of the stock.
02/20/19
02/20/19
UPGRADE

Fly Intel: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Pfizer (PFE) resumed with a Neutral from Sell at Citi with analyst Andrew Baum saying the recent pullback in the stock, along with the 5%-8% 2019-2021 consensus estimate reductions, gives him the opportunity to close his Sell rating. 2. Transocean (RIG) and Diamond Offshore (DO) were upgraded to Overweight from Underweight at Barclays. 3. American Axle (AXL) upgraded to Buy from Neutral at BofA/Merrill with analyst John Murphy citing progress with restructuring, GM's (GM) truck cycle, and balance sheet deleveraging. 4. Credit Suisse (CS) upgraded to Hold from Sell at Berenberg. 5. Ipsen (IPSEY) upgraded to Neutral from Sell at Goldman Sachs with analyst Diana Na citing valuation. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
02/26/19
LEHM
02/26/19
NO CHANGE
LEHM
Galapagos weakness could be tied to Pfizer safety alert, says Barclays
Barclays believes the weakness today in Galapagos NV (GLPG) could be attributed to, at least in part, the FDA's safety communication on Pfizer's (PFE) post-marketing study of 10mg daily Xeljanz. Competitor safety issues with higher dose JAK inhibitors was a major focus of Galapagos' post-earnings conference call last week, Barclays tells investors in a research note. Galapagos management, while limited in what it can say pending the data, seems to believe they can get both doses approved, Barclays contends. Further, the firm points out that the company has received no communication and sees no reason to conclude that the FDA has determined that thromboembolic events are a class effect of the JAKs. Shares of Galapagos are down 1.5%, or $1.45, to $97.28 in late morning trading.
MKGAY Merck KGaA
$0.00

(0.00%)

02/28/19
GHSC
02/28/19
DOWNGRADE
GHSC
Neutral
Entegris downgraded to Neutral from Buy at Seaport Global
Seaport Global analyst Michael Harrison downgraded Entegris (ENTG) to Neutral from Buy. The analyst said that "Merck KGaA's (MKGAY) competing offer for VSM (VSM) potentially spoils Entegris' plans for an all-stock merger of equals. We view the counter-offer as a clear negative, as Entegris may either have to pay more or miss out on a deal with strong strategic rationale."
02/28/19
GHSC
02/28/19
DOWNGRADE
GHSC
Neutral
Versum Materials downgraded to Neutral from Buy at Seaport Global
Seaport Global analyst Michael Harrison downgraded Versum Materials (VSM) to Neutral, saying that while combining Merck KGaA's (MKGAY) offer with that of Entegris (ENTG) makes more sense from a strategic standpoint, from a financial standpoint, its valuation of $5.9B "looks appropriate". Harrison adds that investors would be more pleased with additional premium in the Versum Materials bidding coming from either from Merck or Entegris, but also believes that the potential for the higher offer does not justify a Buy rating.
03/04/19
JEFF
03/04/19
DOWNGRADE
Target $47
JEFF
Hold
Jefferies downgrades Versum to Hold on less favorable risk/reward
Jefferies analyst Laurence Alexander downgraded Versum Materials (VSM) to Hold from Buy while raising his price target for the shares to $47 from $44. With the market already discounting a higher takeover bid from Merck KGaA (MKGAY), the stock's near-term risk/reward is less favorable, Alexander tells investors in a research note. The analyst believes a merger with Entegris (ENTG appears to have slightly higher cost synergies and revenue synergies, with his leveraged buyout model supporting fair value for the new company in 2022 at $73 per share.
03/15/19
UBSW
03/15/19
DOWNGRADE
UBSW
Neutral
Merck KGaA downgraded to Neutral from Buy at UBS
UBS analyst Michael Leuchten downgraded Merck KGaA to Neutral from Buy saying the stock's valuation is now close to his sum-of-the parts analysis. The analyst believes near-term catalysts are now priced into the shares. He lowered his price target for Merck KGaA to EUR 108 from EUR 115.

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INTC

Intel

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AMD

$27.32

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10:42
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10:42
On The Fly
Intel dips after guidance cut, drags down chipmaking peers »

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STX

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Western Digital

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F

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Biogen

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Amgen

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Celgene

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GILD

Gilead

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MMM

3M

$190.77

0.1 (0.05%)

10:30
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Options
3M puts active Friday after a big loss in shares Thursday »

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LOGC

LogicBio Therapeutics

$13.20

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10:28
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Hot Stocks
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HBM

Hudbay Minerals

$6.70

0.11 (1.67%)

10:28
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Hot Stocks
Glass Lewis recommends Hudbay Minerals investors vote for Waterton nominees »

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10:25
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Conference/Events
UBS alternative energy analyst to hold an analyst/industry conference call »

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SCHW

Charles Schwab

$44.93

-0.385 (-0.85%)

10:25
04/26/19
04/26
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10:25
Conference/Events
Charles Schwab to hold a webcast »

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DIS

Disney

$138.97

1.67 (1.22%)

10:24
04/26/19
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10:24
Periodicals
Disney sees $60M in 'Endgame' sales from Thursday previews, Bloomberg reports »

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LOGC

LogicBio Therapeutics

$13.20

(0.00%)

10:23
04/26/19
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04/26/19
10:23
Hot Stocks
Breaking Hot Stocks news story on LogicBio Therapeutics »

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GS

Goldman Sachs

$201.34

-0.11 (-0.05%)

10:22
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10:22
Periodicals
Goldman plans to open stock brokerage in Mexico, Bloomberg says »

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MTN

Vail Resorts

$217.80

0.5 (0.23%)

, TOCA

Tocagen

$9.55

0.42 (4.60%)

10:21
04/26/19
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Fly Intel: Top five analyst initiations »

Catch up on today's…

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Vail Resorts

$217.80

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Tocagen

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DOW

Dow Inc.

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Gilead

$64.80

0.68 (1.06%)

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Reed's

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SBUX

Starbucks

$75.44

-1.63 (-2.12%)

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Axalta Coating

$26.65

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10:21
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Fly Intel: Top five analyst downgrades »

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Starbucks

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Axalta Coating

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Ferrari

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STX

Seagate

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Western Digital

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Cleveland-Cliffs

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0.12 (1.24%)

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Argo Group

$75.29

1.08 (1.46%)

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Upgrade
Fly Intel: Top five analyst upgrades »

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Cleveland-Cliffs

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Argo Group

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ITW

Illinois Tool Works

$152.18

0.915 (0.60%)

MDCO

The Medicines Co.

$31.48

1.64 (5.50%)

ESPR

Esperion

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SFLY

Shutterfly

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MDLZ

Mondelez

$49.97

-0.02 (-0.04%)

10:20
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Mondelez puts active ahead of earnings »

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Treasury Action: yields have extended slightly lower »

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WBC

Wabco

$133.12

-0.08 (-0.06%)

10:17
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10:17
Downgrade
Wabco rating change  »

Wabco downgraded to…

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$NSD

NASDAQ Market Internals

$0.00

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10:17
04/26/19
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Technical Analysis
NASDAQ market internals summary »

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DIS

Disney

$139.40

2.1 (1.53%)

, SSNLF

Samsung

$0.00

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10:16
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Earnings
Fly Intel: What to watch in Spotify earnings report »

Spotify (SPOT) is…

DIS

Disney

$139.40

2.1 (1.53%)

SSNLF

Samsung

$0.00

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SPOT

Spotify

$134.88

2.08 (1.57%)

FOX

Fox Corp.

$37.49

-0.13 (-0.35%)

CMCSA

Comcast

$43.19

0.24 (0.56%)

T

AT&T

$30.64

0.305 (1.01%)

AMZN

Amazon.com

$1,905.19

2.66 (0.14%)

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$NYE

NYSE Market Internals

$0.00

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10:16
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Technical Analysis
NYSE market internals summary »

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Amazon.com

$1,901.49

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, UPS

UPS

$103.84

-1.29 (-1.23%)

10:11
04/26/19
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10:11
On The Fly
Amazon 'goes for the jugular' with one-day Prime shipping »

Shares of Amazon.com…

AMZN

Amazon.com

$1,901.49

-1.04 (-0.05%)

UPS

UPS

$103.84

-1.29 (-1.23%)

WMT

Walmart

$101.87

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TGT

Target

$78.14

-3.6 (-4.40%)

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USO

United States Oil Fund

$13.29

-0.23 (-1.70%)

10:10
04/26/19
04/26
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10:10
Options
Size option block in US Oil Fund as shares slip »

Size option block in US…

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RIG

Transocean

$8.74

-0.19 (-2.13%)

10:05
04/26/19
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10:05
Options
Transocean call volume above normal and directionally bullish »

Bullish option flow…

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10:05
04/26/19
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General news
U.S. consumer sentiment improved to 97.2 in the final April reading »

U.S. consumer sentiment…

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