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RDUS

Radius Health

$18.92

-0.39 (-2.02%)

12:17
03/24/19
03/24
12:17
03/24/19
12:17

Radius presents analysis from Phase 3 ACTIVE trial, data from TYMLOS studies

Radius Health presented a post-hoc analysis of Phase 3 data from different patient populations included in the ACTIVE trial, and results from preclinical studies of abaloparatide and its effect on the development and growth of osteoclasts and on bone resorption during an oral session at ENDO 2019, the Endocrine Society's Annual Meeting and Expo in New Orleans, LA.The first oral presentation titled "The Effect of Abaloparatide on Bone Mineral Density and Fracture Incidence in Postmenopausal Women with Osteoporosis and Osteoarthritis," showed that in a subpopulation of postmenopausal women from the ACTIVE study who also had osteoarthritis, abaloparatide was associated with significant reduction in new vertebral fractures as well as significant improvements in bone mineral density, versus placebo. The relationship between OA and osteoporosis is unclear but increased risk of fragility fracture has been associated with OA despite those patients having higher than average BMD. Of the 2,463 women enrolled in the Phase 3 ACTIVE trial, 888 patients with ongoing OA were identified. The most common sites of OA were at the spine and knee. At 18 months, significant increases in BMD from baseline were observed for abaloparatide versus placebo at the total hip, femoral neck, and lumbar spine; which was consistent with the overall ACTIVE population results. The second oral presentation titled "Different Effects of Abaloparatide and hPTH(1-34) on Osteoclastogenesis and Bone Resorption" used data from preclinical studies of abaloparatide. The analysis provides mechanistic explanations for the net bone gain observed in the ACTIVE trial, indicating that increased bone mass is, at least partly, the consequence of reduced osteoclast activity.

RDUS Radius Health
$18.92

-0.39 (-2.02%)

03/29/18
LEER
03/29/18
INITIATION
Target $53
LEER
Outperform
Radius Health initiated with an Outperform at Leerink
Leerink analyst Geoffrey Porges started Radius Health with an Outperform rating and $53 price target as he believes transdermal patch could expand treated market and Tymlos share.
11/13/18
JPMS
11/13/18
NO CHANGE
JPMS
Overweight
Radius Health shares attractive at current levels, says JPMorgan
JPMorgan analyst Jessica Fye left a recent call with Radius Health management encouraged by the progress with the Tymlos launch. The analyst acknowledges key pipeline data will not read out until 2020/2021, she views Radius as an undervalued stock. She expects 2019 to be a year of continued Tymlos growth as well as one of pipeline execution and sees current share levels as attractive entry point at current levels for those with a longer-term time horizon. Fye keeps an Overweight rating on Radius Health.
02/14/19
HCWC
02/14/19
INITIATION
Target $22
HCWC
Neutral
Radius Health initiated with a Neutral at H.C. Wainwright
H.C. Wainwright analyst Douglas Tsao started Radius Health with a Neutral rating and $22 price target. The company's osteoporosis and nascent oncology portfolios can drive value, but there are "potential head winds before those are realized," says the analyst.

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