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AVRO

Avrobio

$18.27

-0.77 (-4.04%)

07:06
03/25/19
03/25
07:06
03/25/19
07:06

Avrobio reports Q4 EPS (67c), consensus (57c)

"2018 was a very productive year for AVROBIO, as we built a solid financial foundation with our IPO and made significant progress advancing our pipeline of gene therapies for Fabry and other lysosomal storage diseases," commented CEO Geoff MacKay. "We enter 2019 with strong momentum. Our recently-presented preliminary clinical data from the Fabry program builds upon a growing body of evidence for the therapeutic potential of AVR-RD-01 as a gene therapy for patients with this debilitating disease. In addition, we look forward to expanding AVROBIO's clinical activities, with trials for Gaucher disease and cystinosis expected to start in 2019. Finally, after three and a half years of development, we were excited to introduce the plato platform, which includes a proprietary vector system, cell manufacturing solution and conditioning regimen with therapeutic drug monitoring. We believe that plato provides the foundation for the potential worldwide commercialization of our gene therapies. We plan to incorporate plato into our Fabry and Gaucher clinical trials in the second half of 2019."

AVRO Avrobio
$18.27

-0.77 (-4.04%)

10/09/18
GUGG
10/09/18
INITIATION
GUGG
Buy
Avrobio initiated with a Buy at Guggenheim
Guggenheim analyst Whitney Ijem initiated Avrobio with a Buy rating and $35 price target, calling the two-day 61% sell off on the company's Ph1 Fabry data update an overreaction.
11/27/18
LEER
11/27/18
INITIATION
Target $27
LEER
Market Perform
Avrobio initiated with a Market Perform at Leerink
Leerink analyst Mani Foroohar initiated Avrobio with a Market Perform rating and a price target of $27.
11/27/18
LEER
11/27/18
INITIATION
LEER
Leerink initiates select Genetic Medicine names on increasing regulatory clarity
Leerink analyst Mani Foroohar initiated select Genetic Medicine stocks, stating that the field is "is rich with companies developing drugs" to treat rare diseases and that he is increasingly more bullish on "innovation velocity and increasing regulatory clarity in the sector. Based on his "balanced view of pricing dynamics", the analyst issues an Outperform rating on Wave Life Sciences (WVE), Rocket Pharmaceuticals (RCKT), Intellia Therapeutics (NTLA), Eidos Therapeutics (EIDX), Dicerna (DRNA) and Bluebird Bio (BLUE). The analyst likes Wave Life Sciences as a pure play on Oligotherapeutics and its stereopure chemistry platform as a differentiated approach to oligo drug design. Foroohar is positive on Rocket Pharma's lead assets in gene therapies for Fanconi Anemia and Leukocyte Adhesion Deficiency-I "which will likely be the company's first potential approved product." The analyst is positive on Intellia Therapeutics' "robust balance sheet to support development, trading at a material discount to closest comps peers". For Eidos, the analyst cites the prospects of its drug candidate for TTR amyloidosis currently in a placebo-controlled Phase 2 study that may offer a competitive profile relative to Pfizer's (PFE) tafamidis. For Dicerna, Foroohar notes that its DCR-PHXC "is an RNAi therapeutic that targets lactate dehydrogenase A for the treatment of all subtypes of Primary Hyperoxaluria vs. competitor Alnylam's (ALNY) lumasiran, which only treats PH Type 1. For Bluebird Bio, the analyst is positive on its position as a "leader in ex vivo gene therapy, with four programs with visibility towards near-term regulatory approval". Foroohar initiates Avrobio (AVRO), Alnylam (ALNY), and Ionis Pharmaceuticals (IONS) with Market Perform rating based on competitive launches for their products along with "mixed" early signs of their results. The analyst also rates Regenxbio (RGNX) at underperform, saying that its "current valuation more than accounts for robust royalty streams from sales in spinal muscular atrophy" and other partnered assets.
01/17/19
LEER
01/17/19
NO CHANGE
Target $19
LEER
Market Perform
Avrobio price target lowered to $19 from $27 at Leerink
Leerink analyst Mani Foroohar lowered his price target for Avrobio to $19 from $27, while reiterating a Market Perform rating on the shares. While the analyst is positive on recent additions to senior management, he is more conservative on the market opportunity for Fabry gene therapy given the need for higher-intensity preconditioning regimens than the company has used previously, and believes that the potential adoption of value-based annuity pricing models by the industry could pose further risk to Avrobio's bottom line.

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