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AVRO

Avrobio

$18.27

-0.77 (-4.04%)

07:11
03/25/19
03/25
07:11
03/25/19
07:11

Avrobio to start using plato in FAB-201, GAU-201 clinical trials in 2019

Plato consists of a four-plasmid vector system, automation of a closed cell manufacturing process and a conditioning regimen that utilizes therapeutic drug monitoring. Plato was designed to enhance the potency, safety, efficacy, and long-term durability of AVROBIO's gene therapies, and may additionally provide the capability to address CNS manifestations that accompany many lysosomal storage diseases. The company expects to have manufacturing capabilities at 200-liter bioreactor scale in the second half of 2019, with vector production capable of treating a substantial number of patients per year. The automated, closed cell manufacturing system is intended to improve quality and consistency between batches. In addition, its portability may allow for global production using lower-level clean rooms that are cost-effective and in ample supply around the world. The gene therapy product is cryopreserved to simplify logistics and allow convenient scheduling for patients. The company intends to start using plato in its FAB-201 and GAU-201 clinical trials in 2019.

AVRO Avrobio
$18.27

-0.77 (-4.04%)

10/09/18
GUGG
10/09/18
INITIATION
GUGG
Buy
Avrobio initiated with a Buy at Guggenheim
Guggenheim analyst Whitney Ijem initiated Avrobio with a Buy rating and $35 price target, calling the two-day 61% sell off on the company's Ph1 Fabry data update an overreaction.
11/27/18
LEER
11/27/18
INITIATION
Target $27
LEER
Market Perform
Avrobio initiated with a Market Perform at Leerink
Leerink analyst Mani Foroohar initiated Avrobio with a Market Perform rating and a price target of $27.
11/27/18
LEER
11/27/18
INITIATION
LEER
Leerink initiates select Genetic Medicine names on increasing regulatory clarity
Leerink analyst Mani Foroohar initiated select Genetic Medicine stocks, stating that the field is "is rich with companies developing drugs" to treat rare diseases and that he is increasingly more bullish on "innovation velocity and increasing regulatory clarity in the sector. Based on his "balanced view of pricing dynamics", the analyst issues an Outperform rating on Wave Life Sciences (WVE), Rocket Pharmaceuticals (RCKT), Intellia Therapeutics (NTLA), Eidos Therapeutics (EIDX), Dicerna (DRNA) and Bluebird Bio (BLUE). The analyst likes Wave Life Sciences as a pure play on Oligotherapeutics and its stereopure chemistry platform as a differentiated approach to oligo drug design. Foroohar is positive on Rocket Pharma's lead assets in gene therapies for Fanconi Anemia and Leukocyte Adhesion Deficiency-I "which will likely be the company's first potential approved product." The analyst is positive on Intellia Therapeutics' "robust balance sheet to support development, trading at a material discount to closest comps peers". For Eidos, the analyst cites the prospects of its drug candidate for TTR amyloidosis currently in a placebo-controlled Phase 2 study that may offer a competitive profile relative to Pfizer's (PFE) tafamidis. For Dicerna, Foroohar notes that its DCR-PHXC "is an RNAi therapeutic that targets lactate dehydrogenase A for the treatment of all subtypes of Primary Hyperoxaluria vs. competitor Alnylam's (ALNY) lumasiran, which only treats PH Type 1. For Bluebird Bio, the analyst is positive on its position as a "leader in ex vivo gene therapy, with four programs with visibility towards near-term regulatory approval". Foroohar initiates Avrobio (AVRO), Alnylam (ALNY), and Ionis Pharmaceuticals (IONS) with Market Perform rating based on competitive launches for their products along with "mixed" early signs of their results. The analyst also rates Regenxbio (RGNX) at underperform, saying that its "current valuation more than accounts for robust royalty streams from sales in spinal muscular atrophy" and other partnered assets.
01/17/19
LEER
01/17/19
NO CHANGE
Target $19
LEER
Market Perform
Avrobio price target lowered to $19 from $27 at Leerink
Leerink analyst Mani Foroohar lowered his price target for Avrobio to $19 from $27, while reiterating a Market Perform rating on the shares. While the analyst is positive on recent additions to senior management, he is more conservative on the market opportunity for Fabry gene therapy given the need for higher-intensity preconditioning regimens than the company has used previously, and believes that the potential adoption of value-based annuity pricing models by the industry could pose further risk to Avrobio's bottom line.

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QD

Qudian

$3.43

-0.085 (-2.42%)

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JBHT

J.B. Hunt

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1.38 (1.20%)

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BX

Blackstone

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0.78 (1.28%)

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Blackstone

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0.78 (1.28%)

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Bain Capital Specialty Finance

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MLCO

Melco Resorts & Entertainment

$22.73

-2.28 (-9.12%)

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Melco Resorts call volume above normal and directionally bullish »

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WMT

Walmart

$115.52

0.59 (0.51%)

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Cowen retail analyst to hold an analyst/industry conference call »

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$NSD

NASDAQ Market Internals

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$NYE

NYSE Market Internals

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NYSE market internals summary »

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BAX

Baxter

$91.38

1.64 (1.83%)

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Options
Baxter put volume heavy and directionally bearish »

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UBER

Uber

$36.90

1.78 (5.07%)

14:14
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Uber analyst commentary  »

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BA

Boeing

$312.71

-11.4 (-3.52%)

14:12
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Breaking Hot Stocks news story on Boeing »

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14:10
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General news
Wall Street's losses are picking up again »

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TSLA

Tesla

$543.32

32.98 (6.46%)

14:09
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Periodicals
Tesla reaches settlement deal with Michigan over sales ban, Bloomberg says »

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GOOG

Alphabet

$1,483.10

2.82 (0.19%)

, GOOGL

Alphabet Class A

$1,482.12

3 (0.20%)

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GOOG

Alphabet

$1,483.10

2.82 (0.19%)

GOOGL

Alphabet Class A

$1,482.12

3 (0.20%)

DLAKY

Lufthansa

$0.00

(0.00%)

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JMIA

Jumia Technologies

$7.91

0.69 (9.56%)

14:05
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Options
Jumia Technologies call volume above normal and directionally bullish »

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ABT

Abbott

$89.40

0.4 (0.45%)

, BKR

Baker Hughes

$22.96

-0.66 (-2.79%)

14:01
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Earnings
Notable companies reporting before tomorrow's open »

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ABT

Abbott

$89.40

0.4 (0.45%)

BKR

Baker Hughes

$22.96

-0.66 (-2.79%)

ALLY

Ally Financial

$30.46

0.02 (0.07%)

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NFLX

Netflix

$334.75

-4.81 (-1.42%)

, IBM

IBM

$138.83

0.52 (0.38%)

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NFLX

Netflix

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IBM

IBM

$138.83

0.52 (0.38%)

COF

Capital One

$103.10

-1.04 (-1.00%)

AMTD

TD Ameritrade

$50.68

0.17 (0.34%)

UAL

United Airlines

$84.82

-4.86 (-5.42%)

ZION

Zions Bancorp

$50.06

-0.68 (-1.34%)

PNFP

Pinnacle Financial

$62.42

-0.98 (-1.55%)

NAVI

Navient

$13.86

-0.015 (-0.11%)

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FORM

FormFactor

$27.46

-0.07 (-0.25%)

13:56
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Initiation
FormFactor initiated  »

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F

Ford

$9.20

0.035 (0.38%)

13:55
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Options
Ford put volume heavy and directionally bearish »

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CUTR

Cutera

$33.44

-0.44 (-1.30%)

13:53
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BA

Boeing

$321.32

-2.79 (-0.86%)

13:51
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Periodicals
Boeing not expecting 737 Max approval until June or July, CNBC reports »

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  • 29

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13:50
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General news
Treasury Action: yields have dropped to the lows, and Wall Street is headed south »

Treasury Action: yields…

MAXR

Maxar Technologies

$21.10

0.88 (4.35%)

13:47
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Hot Stocks
Maxar Technologies pops after inking deal with Netherlands Ministry of Defense »

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IGT

International Game

$14.41

-0.61 (-4.06%)

13:45
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Options
International Game call volume above normal and directionally bullish »

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LLY

Eli Lilly

$140.65

1.04 (0.74%)

13:35
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Hot Stocks
Eli Lilly to invest over $470M to build new manufacturing facility in Durham »

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BBD

Banco Bradesco

$7.99

-0.445 (-5.28%)

13:35
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Options
Banco Bradesco put volume heavy and directionally bearish »

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