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ARVN

Arvinas

$15.74

-1.2 (-7.08%)

07:12
03/25/19
03/25
07:12
03/25/19
07:12

Arvinas initiates patient dosing in Phase 1 ARV-110 trial

Arvinas announced the initiation of patient dosing in its Phase 1 clinical trial of ARV-110, the company's oral androgen receptor, or AR-targeted Protac protein degrader. The study will evaluate the safety, tolerability and pharmacokinetics of ARV-110 in patients with metastatic castration-resistant prostate cancer, or mCRPC, who have progressed on standard of care therapies. Arvinas believes ARV-110 is the first in a new class of targeted protein degraders to enter human clinical trials and anticipates preliminary data from the study in the second half of the year. The Phase 1 open-label, dose-escalation clinical trial will assess the safety, tolerability and pharmacokinetics of ARV-110 and is expected to enroll approximately 28-36 patients with progressive mCRPC. In addition, the study will evaluate the biochemical and clinical activity of ARV-110, by assessing prostate specific antigen levels, AR degradation, radiographic measurements of evaluable lesions and other exploratory markers of disease burden.

ARVN Arvinas
$15.74

-1.2 (-7.08%)

10/22/18
PIPR
10/22/18
INITIATION
Target $23
PIPR
Overweight
Arvinas initiated with an Overweight at Piper Jaffray
Piper Jaffray analyst Edward Tenthoff started Arvinas with an Overweight rating and $23 price target. The company's approach to degrade disease causing proteins has several advantages over traditional small molecules, Tenthoff tells investors in a research note. He views the company as a leading protein degradation play.
10/22/18
GSCO
10/22/18
INITIATION
Target $17
GSCO
Neutral
Arvinas initiated with a Neutral at Goldman Sachs
Goldman Sachs analyst Terence Flynn started Arvinas with a Neutral rating and $17 price target. The analyst views the current valuation as fair "given existing pre-clinical efficacy and safety data, stage of development and market opportunities." However, he projects blockbuster potential for each Arvinas' drugs, with peak sales for ARV-110 of $2.9bB and $4.7B for ARV-471.
10/22/18
SBSH
10/22/18
INITIATION
Target $21
SBSH
Buy
Arvinas initiated with a Buy at Citi
Citi analyst Yigal Nochomovitz initiated Arvinas with a Buy and $21 price target.
10/22/18
10/22/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Domino's Pizza (DPZ) initiated with a Neutral at UBS. 2. Arco Platform (ARCE) initiated with an Overweight at Morgan Stanley, an Outperform at Itau BBA, and a Buy at Goldman Sachs. 3. Arvinas (ARVN) initiated with a Neutral at Goldman Sachs and an Overweight at Piper Jaffray. 4. Ra Medical Systems (RMED) initiated with a Buy at SunTrust as well as an Overweight at Cantor Fitzgerald and Piper Jaffray. 5. SurveyMonkey (SVMK) initiated with a Buy at SunTrust and BofA/Merrill, an Overweight at JPMorgan, and a Neutral at Credit Suisse and UBS. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

FMCC

Freddie Mac

$0.00

(0.00%)

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GDS

GDS Holdings

$47.16

1.88 (4.15%)

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BIG

Big Lots

$19.17

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Genesco

$36.94

0.38 (1.04%)

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UNVR

Univar

$23.15

0.22 (0.96%)

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PLUG

Plug Power

$3.10

-0.195 (-5.93%)

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    Dec

RGLD

Royal Gold

$117.91

0.64 (0.55%)

, TECK

Teck Resources

$15.71

-0.11 (-0.70%)

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RGLD

Royal Gold

$117.91

0.64 (0.55%)

TECK

Teck Resources

$15.71

-0.11 (-0.70%)

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  • 21

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IR

Ingersoll-Rand

$128.95

1.405 (1.10%)

19:41
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19:41
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19:41
Upgrade
Ingersoll-Rand rating change at Wells Fargo »

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ICPT

Intercept

$119.86

2.42 (2.06%)

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HUN

Huntsman

$22.34

0.37 (1.68%)

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UBER

Uber

$28.65

-0.405 (-1.39%)

18:48
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Uber: Non-consensual kissing of sexual body part reported in 1 in 3M U.S. trips »

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UBER

Uber

$28.65

-0.405 (-1.39%)

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DOMO

Domo

$19.47

-0.19 (-0.97%)

, EZPW

Ezcorp

$5.21

-0.01 (-0.19%)

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DOMO

Domo

$19.47

-0.19 (-0.97%)

EZPW

Ezcorp

$5.21

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DOCU

DocuSign

$69.51

-0.465 (-0.66%)

ULTA

Ulta Beauty

$236.09

-3.27 (-1.37%)

ZUMZ

Zumiez

$30.63

0.67 (2.24%)

CLDR

Cloudera

$10.02

0.16 (1.62%)

MDLA

Medallia

$29.79

0.55 (1.88%)

CRWD

Crowdstrike

$53.00

-2.04 (-3.71%)

AOBC

American Outdoor Brands

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0.38 (4.20%)

YEXT

Yext

$16.62

0.065 (0.39%)

PD

PagerDuty

$24.99

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SAIC

SAIC

$83.82

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ZM

Zoom Video

$69.73

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KFY

Korn/Ferry

$40.26

0.39 (0.98%)

COO

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1 (0.32%)

GWRE

Guidewire

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OKTA

Okta

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UBER

Uber

$28.65

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UBER

Uber

$28.65

-0.405 (-1.39%)

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Uber says 107 total fatalities in 2017-2018 reported in relation to Uber app »

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UBER

Uber

$28.65

-0.405 (-1.39%)

18:34
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Periodicals
Breaking Periodicals news story on Uber »

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CMG

Chipotle

$819.61

10.12 (1.25%)

18:33
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RCII

Rent-A-Center

$26.02

0.36 (1.40%)

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BKH

Black Hills

$76.66

0.01 (0.01%)

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Black Hills utilities receive approval to upsize Renewable Ready program »

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PRIM

Primoris

$21.92

0.3 (1.39%)

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LMAT

LeMaitre

$35.94

-0.09 (-0.25%)

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CLBK

Columbia Financial

$16.33

-0.24 (-1.45%)

18:01
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Columbia Financial expands stock buyback to acquire additional 3M shares »

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AXS

Axis Capital

$58.42

0.31 (0.53%)

17:49
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Hot Stocks
Axis Capital increases quarterly dividend 2.5% to 41c per share »

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  • 26

    Feb

PZZA

Papa John's

$59.67

-0.53 (-0.88%)

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Former Papa John's CEO files suit against ad firm, Bloomberg says »

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  • 11

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THG

Hanover Insurance

$133.80

0.52 (0.39%)

17:47
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Hanover Insurance raises dividend to 65c/shr, announces $2.50 special dividend »

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  • 26

    Feb

BHVN

Biohaven Pharmaceutical

$53.79

-0.235 (-0.44%)

17:46
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Biohaven Pharmaceutical issued patent relating to troriluzole »

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EPZM

Epizyme

$15.32

-0.48 (-3.04%)

17:45
12/05/19
12/05
17:45
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17:45
Upgrade
Morgan Stanley upgrades Epizyme to Overweight ahead of lymphoma data »

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