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ASND

Ascendis Pharma

$115.50

-3.71 (-3.11%)

14:07
03/25/19
03/25
14:07
03/25/19
14:07

Ascendis Pharma announces results of study of hypoparathyroidism at ENDO 2019

Ascendis Pharma announced a study evaluating impact of hypoparathyroidism on patients in a poster at the Endocrine Society's annual meeting, ENDO 2019, in New Orleans. A paucity of data exists on the short-term symptoms and burden of illness experienced by patients with this condition. The study found that, despite treatment with current therapies, 100 percent of patients experienced physical impact, psychological impact, and interference with daily life, reflecting a substantial illness burden from HP. "I have lived with HP for over 25 years and have personally experienced how this debilitating disease affects all areas of life - physical, emotional and social," said Deb Murphy, President of the HypoPARAthyroidism Association. "This study highlights that currently available therapies are still not enough. It is critical to not only increase awareness of HP, but to develop new treatment options that address all aspects of the disease and improve patients' quality-of-life." These results clearly show the need for a treatment option that can address all aspects of HP to help alleviate the significant quality-of-life issues these patients face every day," said Jonathan Leff, M.D., Ascendis Pharma's Chief Medical Officer. "Our endocrinology rare disease pipeline includes a potential new therapy for hypoparathyroidism, TransCon PTH, which is designed to restore PTH to physiologic levels continuously for 24 hours a day. By providing sustained levels of PTH, we hope to control and maintain serum and urinary calcium levels. In doing so, we hope to prevent many of the debilitating quality-of-life challenges highlighted in this study." TransCon PTH is a long-acting prodrug of parathyroid hormone, in development as a potential once-daily replacement therapy for HP. PaTH Forward is a global phase 2 trial designed to evaluate the safety, tolerability and efficacy of TransCon PTH in adult subjects with hypoparathyroidism. The trial is also evaluating a titration regimen for the complete withdrawal of standard of care. The company anticipates top-line results from the

ASND Ascendis Pharma
$115.50

-3.71 (-3.11%)

03/04/19
CANT
03/04/19
NO CHANGE
CANT
Ascendis Pharma price target raised to $185 from $102 at Cantor Fitzgerald
03/04/19
CANT
03/04/19
NO CHANGE
Target $185
CANT
Overweight
Ascendis Pharma price target raised to $185 from $102 at Cantor Fitzgerald
Cantor Fitzgerald analyst Alethia Young raised her price target for Ascendis Pharma to $185 from $102 as she was "positively surprised" that the TransCon hGH study for growth hormone achieved a superior result on annualized growth velocity of .86cm. The analyst thinks that the expectation had been non-inferiority with a slightly favorable numerical trend. Young also thinks safety was clean as well, which has been a challenge with other long acting growth hormones. She would expect shares to trade up 50%-100% based on her model, and sees continued upside from shares as additional programs, such as TransCon PTH, achieve proof of concept and more candidates from the proprietary TransCon platform enter the clinic. The analyst reiterates an Overweight rating on the shares.
03/07/19
JPMS
03/07/19
NO CHANGE
Target $145
JPMS
Overweight
Ascendis Pharma price target raised to $145 from $85 at JPMorgan
JPMorgan analyst Jessica Fye raised her price target for Ascendis Pharma to $145 from $85 and reiterates an Overweight rating on the shares. While the analyst does not see an "obvious catalyst" over the next two years to drive a similar magnitude single-day move as Monday's Phase III data, she sees a "compelling case for continued steady value creation." Ascendis' platform is now de-risked and its story "is still in the early innings with multiple untapped levers in the model," Fye tells investors in a research note.
03/07/19
WEDB
03/07/19
NO CHANGE
Target $217
WEDB
Outperform
Ascendis Pharma price target raised to $217 from $81 at Wedbush
Wedbush analyst Liana Moussatos raised her price target for Ascendis Pharma to $217 from $81 to her acquisition price following "impressive" topline results from the pivotal Phase 3 heiGHt trial testing TransCon hGH for treatment of pediatric growth hormone deficiency. The analyst believes the results not only validates Ascendis proprietary TransCon technology and its ability to create best-in-class clinical profiles but may also lead to Ascendis' acquisition if fliGHt results in Q2 achieve at least non-inferiority. Moussatos reiterates an Outperform rating on the shares.

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RBB Bancorp

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Franklin Resources

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TSLA

Tesla

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Costamare

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Roku

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Veracyte

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Apple

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Alphabet

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Alphabet

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NVDA

Nvidia

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Enterprise Financial

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