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SNDX

Syndax

$5.26

(0.00%)

10:36
04/01/19
04/01
10:36
04/01/19
10:36

Syndax updates findings from melanoma, NSCLC cohorts of ENCORE 601 trial

Syndax Pharmaceuticals (SNDX) announced the presentation of updated findings from the melanoma and non-small cell lung cancer, or NSCLC, cohorts of ENCORE 601, the company's Phase 1b/2 trial evaluating the efficacy and safety of entinostat, its once-weekly, oral, small molecule, class I HDAC inhibitor, in combination with Keytruda, Merck's (MRK) anti-PD-1 therapy. The data were presented during oral presentations at the American Association of Cancer Research Annual Meeting. The company presented results from the ENCORE 601 melanoma cohort that enrolled patients whose disease had progressed on or after anti-PD-1 therapy. Of 53 patients treated, a confirmed objective response was observed in 19% of patients per irRECIST criteria, with a clinical benefit rate of 36%. Median duration of response is 13 months. Four responders, all of whom have been on study therapy for over a year, currently remain on treatment. Efficacy results in patients who also received prior Yervoy therapy were consistent with the overall population. The entinostat-pembrolizumab combination was well tolerated with a manageable toxicity profile. Briggs Morrison, M.D., CEO of Syndax, said, "Both indications represent areas of high unmet need and we believe that available data warrant consideration to move the entinostat-pembrolizumab combination into one or more registration trials. As previously communicated, we look forward to determining next steps for the combination program following availability of overall survival results from E2112, our Phase 3 registration trial of entinostat plus exemestane in HR+, HER2- breast cancer, the next interim readout of which is expected in the second quarter of this year."

  • 07

    May

SNDX Syndax
$5.26

(0.00%)

01/07/19
RILY
01/07/19
INITIATION
Target $40
RILY
Buy
Syndax resumed with a Buy at B. Riley FBR
B. Riley FBR analyst Harshita Polishetty resumed coverage on Syndax with a Buy and $40 price target.
03/08/19
HCWC
03/08/19
NO CHANGE
Target $16
HCWC
Buy
Syndax price target lowered to $16 from $22 at H.C. Wainwright
H.C. Wainwright analyst Edward White lowered his price target for Syndax Pharmaceuticals to $16 due to removing entinostat in combination with checkpoint inhibitors in non-small cell lung cancer and melanoma from his valuation. The analyst keeps a Buy rating on the shares.
03/08/19
NOMU
03/08/19
NO CHANGE
Target $16
NOMU
Buy
Syndax price target raised to $16 from $12 at Nomura Instinet
Nomura Instinet analyst Christopher Marai raised his price target for Syndax Pharmaceuticals to $16 following the company's Q4 results and keeps a Buy rating on the shares. The analyst says Syndax is "prioritizing for success" in 2019 and beyond.
03/08/19
BTIG
03/08/19
NO CHANGE
Target $19
BTIG
Buy
Syndax price target lowered to $19 from $29 at BTIG
BTIG analyst Robert Hazlett lowered his price target on Syndax to $19 after its announced miss in the primary Progression-free survival Phase 2 study for Entinostat immuno-oncology combinations in Triple-negative breast cancer and ovarian cancer. The analyst says the company is now prioritizing its pipeline to focus on Entinostat in breast cancer with upcoming readouts expected in Q2. Hazlett is keeping his Buy rating on Syndax.

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BX

Blackstone

$47.10

0.62 (1.33%)

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GOOG

Alphabet

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5.88 (0.49%)

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Alphabet Class A

$1,214.62

6.18 (0.51%)

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Alphabet

$1,213.86

5.88 (0.49%)

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Alphabet Class A

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SPX

S&P 500

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SPDR S&P 500 ETF Trust

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3.1 (1.06%)

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Trump working with Congress on 'powerful' Turkey sanctions »

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S&P 500

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SPDR S&P 500 ETF Trust

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AGN

Allergan

$169.06

1.255 (0.75%)

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LYFT

Lyft

$39.49

1.8 (4.78%)

, UBER

Uber

$30.09

1.19 (4.12%)

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LYFT

Lyft

$39.49

1.8 (4.78%)

UBER

Uber

$30.09

1.19 (4.12%)

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GM

General Motors

$35.57

0.9 (2.60%)

15:59
10/13/19
10/13
15:59
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15:59
Periodicals
UAW boosting strike pay as General Motor walkout continues, Reuters says »

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MRK

Merck

$84.31

0.6 (0.72%)

, JNJ

Johnson & Johnson

$131.35

2.32 (1.80%)

15:49
10/13/19
10/13
15:49
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Periodicals
Congo to start using Johnson & Johnson Ebola vaccine next month, Reuters says »

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MRK

Merck

$84.31

0.6 (0.72%)

JNJ

Johnson & Johnson

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2.32 (1.80%)

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HMTV

Hemisphere Media

$11.70

0.05 (0.43%)

15:48
10/13/19
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15:48
Initiation
Hemisphere Media initiated  »

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PFE

Pfizer

$36.11

0.31 (0.87%)

15:37
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CNCE

Concert Pharmaceuticals

$5.85

(0.00%)

15:29
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Concert Pharmaceuticals presents Phase 2 data in Alopecia Areata »

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INCY

Incyte

$76.14

0.38 (0.50%)

15:23
10/13/19
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Incyte announces 52-week results from Phase 2 study of Ruxolitinib cream »

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LLY

Eli Lilly

$108.37

1.54 (1.44%)

14:15
10/13/19
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14:15
Hot Stocks
Eli Lilly says Taltz met co-primary endpoints in Phase 3 plaque psoriasis study »

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PCG

PG&E

$8.08

0.3 (3.86%)

07:46
10/13/19
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PG&E says all customers impacted by safety shutoffs now have power »

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BNTX

BioNTech

$13.50

-0.85 (-5.92%)

, VIR

Vir Biotechnology

$14.06

(0.00%)

07:18
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On The Fly
Opening Day: BioNTech raises $150M in smaller than expected IPO »

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BNTX

BioNTech

$13.50

-0.85 (-5.92%)

VIR

Vir Biotechnology

$14.06

(0.00%)

HBT

HBT Financial

$15.56

(0.00%)

SFTBF

SoftBank

$0.00

(0.00%)

SFTBY

SoftBank

$0.00

(0.00%)

WE

We Company

$0.00

(0.00%)

KRAT

Karat Packaging

$0.00

(0.00%)

POST

Post Holdings

$101.19

1.94 (1.95%)

IPHA

Innate Pharma

$0.00

(0.00%)

BRBR

BellRing Brands

$0.00

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ANGO

AngioDynamics

$14.54

0.12 (0.83%)

, BAYRY

Bayer

$0.00

(0.00%)

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Conference/Events
Healthcare Made Practical to hold a symposium »

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ANGO

AngioDynamics

$14.54

0.12 (0.83%)

BAYRY

Bayer

$0.00

(0.00%)

BSX

Boston Scientific

$38.22

0.22 (0.58%)

BTG

B2Gold

$3.25

-0.2 (-5.80%)

JNJ

Johnson & Johnson

$131.35

2.32 (1.80%)

LLY

Eli Lilly

$108.37

1.54 (1.44%)

MDT

Medtronic

$107.61

0.24 (0.22%)

PFE

Pfizer

$36.11

0.31 (0.87%)

PHG

Philips

$42.88

0.99 (2.36%)

TRUMY

Terumo

$0.00

(0.00%)

VAR

Varian Medical

$110.78

1.84 (1.69%)

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AMBA

Ambarella

$53.62

1.25 (2.39%)

, ON

ON Semiconductor

$18.74

0.67 (3.71%)

09:31
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09:31
On The Fly
Week in Review: How Trump's policies moved stocks »

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AMBA

Ambarella

$53.62

1.25 (2.39%)

ON

ON Semiconductor

$18.74

0.67 (3.71%)

AAPL

Apple

$236.21

6.12 (2.66%)

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BBBY

Bed Bath & Beyond

$12.98

0.89 (7.36%)

, AMZN

Amazon.com

$1,730.79

11.115 (0.65%)

08:48
10/12/19
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08:48
Periodicals
Bed Bath & Beyond not a bargain, Barron's says »

While Bed Bath &…

BBBY

Bed Bath & Beyond

$12.98

0.89 (7.36%)

AMZN

Amazon.com

$1,730.79

11.115 (0.65%)

TGT

Target

$111.86

1.29 (1.17%)

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SNE

Sony

$58.16

0.83 (1.45%)

, MSFT

Microsoft

$139.62

0.52 (0.37%)

08:39
10/12/19
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08:39
Periodicals
Activision, Take-Two to benefit from next videogame cycle, Barron's says »

Sony (SNE) has announced…

SNE

Sony

$58.16

0.83 (1.45%)

MSFT

Microsoft

$139.62

0.52 (0.37%)

ATVI

Activision Blizzard

$54.80

1.1 (2.05%)

TTWO

Take-Two

$122.42

0.02 (0.02%)

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K

Kellogg

$62.14

-0.27 (-0.43%)

08:27
10/12/19
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08:27
Periodicals
Kellogg stock looking like worth 'snacking on,' Barron's says »

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  • 29

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JNJ

Johnson & Johnson

$131.35

2.32 (1.80%)

, ITW

Illinois Tool Works

$154.56

4.68 (3.12%)

08:20
10/12/19
10/12
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08:20
Periodicals
J&J, Pentair among stocks with sage, growing dividends, Barron's says »

Investors seeking yield…

JNJ

Johnson & Johnson

$131.35

2.32 (1.80%)

ITW

Illinois Tool Works

$154.56

4.68 (3.12%)

NUE

Nucor

$52.69

2.48 (4.94%)

PNR

Pentair

$37.33

1.215 (3.36%)

GWW

Grainger

$305.24

16.49 (5.71%)

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    Oct

ANGO

AngioDynamics

$14.54

0.12 (0.83%)

, BAYRY

Bayer

$0.00

(0.00%)

04:55
10/12/19
10/12
04:55
10/12/19
04:55
Conference/Events
Healthcare Made Practical to hold a symposium »

Symposium on Clinical…

ANGO

AngioDynamics

$14.54

0.12 (0.83%)

BAYRY

Bayer

$0.00

(0.00%)

BSX

Boston Scientific

$38.22

0.22 (0.58%)

BTG

B2Gold

$3.25

-0.2 (-5.80%)

JNJ

Johnson & Johnson

$131.35

2.32 (1.80%)

LLY

Eli Lilly

$108.37

1.54 (1.44%)

MDT

Medtronic

$107.61

0.24 (0.22%)

PFE

Pfizer

$36.11

0.31 (0.87%)

PHG

Philips

$42.88

0.99 (2.36%)

TRUMY

Terumo

$0.00

(0.00%)

VAR

Varian Medical

$110.78

1.84 (1.69%)

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THTX

Theratechnologies

$3.76

0.01 (0.27%)

18:32
10/11/19
10/11
18:32
10/11/19
18:32
Hot Stocks
Theratechnologies: Tesamorelin study results on NAFLD published in Lancet HIV »

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WEN

Wendy's

$20.76

0.76 (3.80%)

18:26
10/11/19
10/11
18:26
10/11/19
18:26
Hot Stocks
Wendy's CEO: We are really focused on the long term »

In an interview on…

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GOOG

Alphabet

$1,213.86

5.88 (0.49%)

, GOOGL

Alphabet Class A

$1,214.62

6.18 (0.51%)

18:25
10/11/19
10/11
18:25
10/11/19
18:25
Periodicals
Breaking Periodicals news story on Alphabet, Alphabet Class A »

DOJ to more closely…

GOOG

Alphabet

$1,213.86

5.88 (0.49%)

GOOGL

Alphabet Class A

$1,214.62

6.18 (0.51%)

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BA

Boeing

$374.90

3.97 (1.07%)

18:22
10/11/19
10/11
18:22
10/11/19
18:22
Hot Stocks
Boeing board separates CEO and Chairman roles »

Boeing announced that its…

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