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ETTX

Entasis Therapeutics

$6.45

(0.00%)

08:05
04/04/19
04/04
08:05
04/04/19
08:05

Entasis Therapeutics initiates Phase 3 ATTACK trial

Entasis Therapeutics announced the initiation of the ATTACK Phase 3 pivotal clinical trial to evaluate ETX2514SUL, a fixed-dose combination of its broad-spectrum ss-lactamase inhibitor ETX2514 with sulbactam, for the treatment of patients with pneumonia and bloodstream infections caused by carbapenem-resistant Acinetobacter baumannii. A. baumannii is a Gram-negative bacterium that causes severe infections and is associated with high mortality, increasing rates of antibiotic resistance and growing significance as a hospital-acquired infection due to limited treatment options. Outbreaks of A. baumannii typically occur in intensive care units and healthcare settings with seriously ill patients and can either cause or contribute to death.

ETTX Entasis Therapeutics
$6.45

(0.00%)

10/22/18
FBCO
10/22/18
INITIATION
Target $18
FBCO
Outperform
Entasis Therapeutics initiated with an Outperform at Credit Suisse
Credit Suisse analyst Martin Auster started Entasis Therapeutics with an Outperform rating and $18 price target. The analyst notes that Entasis has two Phase 3-ready assets, with ETX2514 being the key value driver for the stock. ETX2514 is being developed to address difficult-to-treat Acinetobacter infections, and has shown promising preclinical efficacy, good tissue distribution, and a clean safety profile to date, he contends. Auster is modeling a 45% probability of success to this program, but projects a potential $400M global peak opportunity by 2033 in this setting.
10/24/18
RHCO
10/24/18
INITIATION
Target $20
RHCO
Buy
Entasis Therapeutics initiated with a Buy at SunTrust
SunTrust analyst Edward Nash initiated Entasis Therapeutics with a Buy rating and a price target of $20, saying the company is "uniquely positioned by targeting bacterial infections where few therapeutic options exist" while also "increasing rates of multi-drug resistance". The analyst notes that Entasis' lead antibiotic "has the potential to grab significant market share as the drug will target well-defined patient populations with limited treatment options" given up to 200K of registered Acinetobacter infections in the U.S. and the E.U.
10/24/18
10/24/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Tesla (TSLA) initiated with an Outperform at JMP Securities. 2. Comcast (CMCSA) resumed with a Buy at Deutsche Bank, reinstated with a Buy at Citi, and assumed with a Neutral at Guggenheim. 3. 2U (TWOU) initiated with a Buy at Needham. 4. Corbus Pharmaceuticals (CRBP) initiated with a Buy at B. Riley FBR. 5. Entasis Therapeutics (ETTX) initiated with a Buy at SunTrust. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
11/08/18
FBCO
11/08/18
NO CHANGE
Target $18
FBCO
Outperform
NEJM article on Entasis' Zoli increases awareness, validates novelty, says Credit Suisse
Credit Suisse analyst Martin Auster notes that Entasis Therapeutics' Phase 2 trial produced positive results, per protocol, demonstrating Zoliflodacin's potential impact on the growing antibiotic-resistance epidemic. As characterized by an NEJM editorial, N. gonorrhea can be a devastating infection if untreated, so the emergence of antibiotic-resistant strands is rather troublesome, he contends, adding that the article describes Zoli's single-dose regimen as "promising," owing to the challenges that occur when following up with patients. Auster continues to believe that an oral, single dose alternative to the SoC will add visibility and credibility to the company's novel pipeline. The analyst reiterates an Outperform rating and $18 price target on the shares.

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