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GNPX

Genprex

$1.69 /

-0.04 (-2.31%)

08:33
04/08/19
04/08
08:33
04/08/19
08:33

Genprex collaborators report preclinical data for TUSC2 gene with pembrolizumab

Genprex reported that its collaborators from The University of Texas MD Anderson Cancer Center presented positive preclinical data for the combination of the TUSC2 gene with an anti-PD1 antibody, pembrolizumab, for the treatment of lung cancer in a poster presented at the American Association of Cancer Research Meeting 2019. The TUSC2 gene is a tumor suppressor gene, the active agent in Genprex's Oncoprex immunogene therapy. The poster, entitled "Development of an improved humanized patient-derived xenograft, Hu-PDX, mouse model for evaluation of antitumor immune response in lung cancer" showed that TUSC2 combined with checkpoint blockade was more effective than checkpoint blockade alone in increasing the survival of mice with human immune cells that had metastatic lung cancer. The TUSC2 treatment with the checkpoint inhibitor pembrolizumab slowed tumor growth significantly. Pembrolizumab previously had no effect on tumor growth in non-humanized mice. The data also demonstrated the Hu-PDX model as an improved platform for evaluation of immunotherapy.

GNPX Genprex
$1.69 /

-0.04 (-2.31%)

04/01/19 Maxim
Genprex downgraded to Hold from Buy at Maxim
09/14/18
On The Fly: Top five analyst initiations
09/14/18 Maxim
Genprex initiated with a Buy at Maxim
09/14/18 Maxim
Genprex initiated with a Buy at Maxim

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Earnings
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Earnings
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Recommendations
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Earnings
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