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ALBO

Albireo Pharma

$34.57

1.42 (4.28%)

12:51
04/14/19
04/14
12:51
04/14/19
12:51

Albireo presents data from Phase 2 clinical trial evaluating A4250

Albireo Pharma announced that results in Alagille syndrome and biliary atresia patients from its completed Phase 2 clinical trial evaluating A4250 in pediatric cholestasis were presented at the European Association for the Study of the Liver The International Liver Congress 2019 in Vienna, Austria. A4250 is a highly potent and selective inhibitor of the ileal bile acid transporter currently being studied in a Phase 3 clinical trial in children with progressive familial intrahepatic cholestasis, a life-threatening, rare cholestatic liver disease. Albireo plans to initiate a second A4250 pivotal trial, in biliary atresia, in the second half of 2019. The open-label, multicenter, dose-finding Phase 2 clinical trial assessed the safety and tolerability of A4250 in 20 children with cholestatic liver diseases, including PFIC, Alagille syndrome and biliary atresia. Efficacy endpoints included change in serum bile acid levels and pruritus. A4250 was administered orally in doses ranging from 10 microg/kg to 200 microg/kg once daily for 4 weeks. A4250 demonstrated marked sBA reductions of up to 92% in the majority of Alagille patients. The majority of Alagille patients also showed improvement in pruritus as measured by three different scales. One patient had an elevation in bile acids versus baseline. No effect was observed in a third patient with a low baseline sBA. These data, combined with the total dataset of n =24, form the basis for a pivotal development program in a second indication, biliary atresia. In patients with Alagille and biliary atresia, A4250 was generally well-tolerated. Adverse events, including some increased transaminases, were mild and transient. Two Alagille patients with high baseline transaminase levels experienced further increases, which informed the decision to not dose escalate.

  • 05

    Jun

ALBO Albireo Pharma
$34.57

1.42 (4.28%)

04/20/18
JEFF
04/20/18
INITIATION
Target $50
JEFF
Buy
Albireo Pharma initiated with a Buy at Jefferies
Jefferies analyst Eun Yang starts Albireo Pharma with a Buy rating and $50 price target. The company is a "relatively under-recognized story," but has an attractive Phase 3 pediatric orphan liver disease product, designed to address a real unmet need, Yang tells investors in a research note. She thinks appreciation in the shares is likely ahead of the Phase 3 lead product data towards the end of 2019.
04/20/18
04/20/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Roku (ROKU) initiated with a Hold at Loop Capital. 2. Merit Medical (MMSI) initiated with a Buy at Needham. 3. Wingstop (WING) initiated with a Buy at BTIG. 4. Globant (GLOB) initiated with a Hold at HSBC. 5. Albireo Pharma (ALBO) initiated with a Buy at Jefferies. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
02/28/19
HCWC
02/28/19
INITIATION
Target $62
HCWC
Buy
Albireo Pharma initiated with a Buy at H.C. Wainwright
H.C. Wainwright analyst Ed Arce started Albireo Pharma with a Buy rating and $62 price target. Odevixibat is "highly differentiated" and likely to quickly become the standard-of-care for progressive familial intrahepatic cholestasis, Arce tells investors in a research note. Further, the analyst says PFIC is "only the beginning for odevixibat."
02/28/19
02/28/19
INITIATION

Fly Intel: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Wayfair (W) initiated with a Hold at Argus. 2. Molina Healthcare (MOH) initiated with a Market Perform at Cowen. 3. Albireo Pharma (ALBO) initiated with a Buy at H.C. Wainwright. 4. Vista Outdoor (VSTO) initiated with a Buy at B. Riley FBR. 5. Atlassian (TEAM) initiated with a Hold at Deutsche Bank. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.

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