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WVE

Wave Life Sciences

$24.69

-9.36 (-27.49%)

10:44
04/16/19
04/16
10:44
04/16/19
10:44

Wave Life Sciences suvodirsen data with little read-through for efficacy, says SVB Leerink

SVB Leerink analyst Mani Foroohar says that Wave Life Sciences' first-in-human safety data from the Phase I trial of suvodirsen in exon 51 skipping-amenable Duchenne Muscular Dystrophy shows that it was generally sage and well-tolerated up to the 5mg/kg dose, and notes the company has selected the 3.0mg/kg and 4.5mg/kg doses to pivotal trials. While the stock is trading down and investors seem to see negative read-throughs for the potential efficacy of suvodirsen at 5mg/kg, given that drisapersen was dosed at 6mg/kg in clinical trials, the analyst believes that due to differences in chemistry between the compounds, comparison of doses between drugs is not appropriate proxy of potential efficacy. Foroohar maintains his 30% probability of success on the suvodirsen program and reiterates an Outperform rating on the shares.

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WVE Wave Life Sciences
$24.69

-9.36 (-27.49%)

08/07/18
STFL
08/07/18
INITIATION
Target $56
STFL
Buy
Wave Life Sciences initiated with a Buy at Stifel
Stifel analyst Paul Matteis initiated Wave Life Sciences (WVE) with a Buy rating and $56 price target, stating that he sees Takeda's (TKPYY) $170M upfront payment as validating to its platform and set of CNS candidates. Wave is one of his favorite names ahead of a catalyst-rich 12-18 months that includes proof-of-concept data in Huntington's in the first half of 2019, and safety and efficacy data for Wave's candidate in Duchenne, Matteis tells investors.
11/27/18
LEER
11/27/18
INITIATION
Target $61
LEER
Outperform
Wave Life Sciences initiated with an Outperform at Leerink
Leerink analyst Mani Foroohar initiated Wave Life Sciences with an Outperform rating and a price target of $61.
11/27/18
LEER
11/27/18
INITIATION
LEER
Leerink initiates select Genetic Medicine names on increasing regulatory clarity
Leerink analyst Mani Foroohar initiated select Genetic Medicine stocks, stating that the field is "is rich with companies developing drugs" to treat rare diseases and that he is increasingly more bullish on "innovation velocity and increasing regulatory clarity in the sector. Based on his "balanced view of pricing dynamics", the analyst issues an Outperform rating on Wave Life Sciences (WVE), Rocket Pharmaceuticals (RCKT), Intellia Therapeutics (NTLA), Eidos Therapeutics (EIDX), Dicerna (DRNA) and Bluebird Bio (BLUE). The analyst likes Wave Life Sciences as a pure play on Oligotherapeutics and its stereopure chemistry platform as a differentiated approach to oligo drug design. Foroohar is positive on Rocket Pharma's lead assets in gene therapies for Fanconi Anemia and Leukocyte Adhesion Deficiency-I "which will likely be the company's first potential approved product." The analyst is positive on Intellia Therapeutics' "robust balance sheet to support development, trading at a material discount to closest comps peers". For Eidos, the analyst cites the prospects of its drug candidate for TTR amyloidosis currently in a placebo-controlled Phase 2 study that may offer a competitive profile relative to Pfizer's (PFE) tafamidis. For Dicerna, Foroohar notes that its DCR-PHXC "is an RNAi therapeutic that targets lactate dehydrogenase A for the treatment of all subtypes of Primary Hyperoxaluria vs. competitor Alnylam's (ALNY) lumasiran, which only treats PH Type 1. For Bluebird Bio, the analyst is positive on its position as a "leader in ex vivo gene therapy, with four programs with visibility towards near-term regulatory approval". Foroohar initiates Avrobio (AVRO), Alnylam (ALNY), and Ionis Pharmaceuticals (IONS) with Market Perform rating based on competitive launches for their products along with "mixed" early signs of their results. The analyst also rates Regenxbio (RGNX) at underperform, saying that its "current valuation more than accounts for robust royalty streams from sales in spinal muscular atrophy" and other partnered assets.
12/06/18
12/06/18
NO CHANGE

Mizuho defending Wave Life Sciences after stock decline
Mizuho analyst Salim Syed maintained a Buy rating and $65 price target on Wave Life Sciences, and defended the stock after its double digit decline. Syed said some of the decline was related to the broader market decline, as the tape is generally red, but some is Wave Life specific, as a lack of details in the company's recent press release has disappointed some investors. The analyst said he spoke to management and believes the decline is unwarranted, as management alleviated concerns regarding the drug trial.

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CYCN

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FAST

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ATR

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BBY

Best Buy

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0.24 (0.33%)

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ISRG

Intuitive Surgical

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BHB

Bar Harbor Bankshares

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ATVI

Activision Blizzard

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0.31 (0.69%)

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Electronic Arts

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GME

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NTDOY

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SCOR

comScore

$12.91

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SRE

Sempra Energy

$127.42

0.1 (0.08%)

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SPR

Spirit AeroSystems

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BLK

BlackRock

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TRV

Travelers

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2.93 (2.16%)

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GBCI

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Earnings
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BLMN

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APHA

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CNP

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0.28 (0.93%)

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BANF

BancFirst

$55.58

-0.34 (-0.61%)

16:30
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Earnings
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Options
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ZSAN

Zosano Pharma

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