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WVE

Wave Life Sciences

$24.68

-9.37 (-27.52%)

14:42
04/16/19
04/16
14:42
04/16/19
14:42

Wave Life Sciences downgraded to Hold from Buy at Stifel

As previously reported, Stifel analyst Paul Matteis downgraded Wave Life Sciences to Hold from Buy, and reduced his target price on shares to $26 from $53. The analyst believes the company's Duchenne muscular dystrophy, or DMD, update from this morning "raises concerns around suvodirsen and more broadly, the degree to which leveraging stereochemistry will lead to a differentiated ASO-based medicines." While Matteis still sees Huntington's disease as a potential source of upside for the stock, the "recent delay -- especially in light of the DMD update this morning -- has reduced [the analyst's] level of conviction in Wave management's execution and the bull-case on its platform/technology."

  • 16

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    Apr

WVE Wave Life Sciences
$24.68

-9.37 (-27.52%)

12/06/18
12/06/18
NO CHANGE

Mizuho defending Wave Life Sciences after stock decline
Mizuho analyst Salim Syed maintained a Buy rating and $65 price target on Wave Life Sciences, and defended the stock after its double digit decline. Syed said some of the decline was related to the broader market decline, as the tape is generally red, but some is Wave Life specific, as a lack of details in the company's recent press release has disappointed some investors. The analyst said he spoke to management and believes the decline is unwarranted, as management alleviated concerns regarding the drug trial.
04/16/19
LEER
04/16/19
NO CHANGE
LEER
Outperform
Wave Life Sciences suvodirsen data with little read-through for efficacy, says SVB Leerink
SVB Leerink analyst Mani Foroohar says that Wave Life Sciences' first-in-human safety data from the Phase I trial of suvodirsen in exon 51 skipping-amenable Duchenne Muscular Dystrophy shows that it was generally sage and well-tolerated up to the 5mg/kg dose, and notes the company has selected the 3.0mg/kg and 4.5mg/kg doses to pivotal trials. While the stock is trading down and investors seem to see negative read-throughs for the potential efficacy of suvodirsen at 5mg/kg, given that drisapersen was dosed at 6mg/kg in clinical trials, the analyst believes that due to differences in chemistry between the compounds, comparison of doses between drugs is not appropriate proxy of potential efficacy. Foroohar maintains his 30% probability of success on the suvodirsen program and reiterates an Outperform rating on the shares.
04/16/19
MZHO
04/16/19
NO CHANGE
Target $65
MZHO
Buy
Safety data from Wave Life's Exon-51 SAD DMD trial seems reasonably clean, says Mizuho
Mizuho analyst Salim Syed notes that Wave Life Sciences disclosed safety data from its Phase 1 Exon-51 SAD DMD trial, and based on this Phase 1 trial and preclinical work, the company has selected two doses to move forward into its Phase 2/3 trial, 3mg/kg and 4.5mg/kg. The analyst believes the safety data seems "reasonably clean," and that the Street should be not be getting hung up on the reported adverse events. Syed reiterates a Buy rating and $65 price target on the shares.
04/16/19
STFL
04/16/19
DOWNGRADE
STFL
Hold
Wave Life Sciences downgraded to Hold from Buy at Stifel

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FMC

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ECL

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ACRGF

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CRM

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FB

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MSFT

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NOW

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FB

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MSFT

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GOOG

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GBX

Greenbrier

$33.37

0.12 (0.36%)

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STI

SunTrust

$63.77

0.475 (0.75%)

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UAA

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PEP

PepsiCo

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NMIH

NMI Holdings

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TRX

Tanzanian Royalty

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TROW

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TROW

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ENV

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GTLS

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BA

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DHR

Danaher

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ULTA

Ulta Beauty

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-1.07 (-0.30%)

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GTLS

Chart Industries

$88.07

1.13 (1.30%)

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CF

CF Industries

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0.77 (1.76%)

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DHR

Danaher

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-3.3 (-2.57%)

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