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MITO

Stealth Biotherapeutics

$13.22

(0.00%)

18:02
04/16/19
04/16
18:02
04/16/19
18:02

Stealth Biotherapeutics says TAZPOWER results support previous findings

Stealth BioTherapeutics announced "positive" results from the open-label extension of the Phase 2/3 TAZPOWER study of elamipretide, an investigational drug, in patients with genetically confirmed Barth syndrome. Barth syndrome is an ultra-rare mitochondrial disease in which reduced levels of the mitochondrial phospholipid cardiolipin are associated with skeletal muscle weakness, debilitating fatigue, cardiac abnormalities, recurrent infections, delayed growth and reduced life expectancy. The TAZPOWER open-label results, presented at the 2019 MDA Clinical & Scientific Conference, demonstrated potential for elamipretide to improve the relative levels of normal to abnormal cardiolipin which are diagnostic for the disease, as well as measures of exercise performance and patient-reported outcomes. "These Phase 2/3 results support previous pre-clinical findings suggesting that elamipretide may help improve cardiolipin levels," said Dr. Hilary Vernon, TAZPOWER trial investigator, Associate Professor of Pediatrics at the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine and Director, Barth Syndrome Clinic at Kennedy Krieger Institute, Baltimore, MD. "Based on the correlation of the cardiolipin ratio with disease severity, these changes in the cardiolipin ratio data may suggest that elamipretide has the potential to modify the course of disease in Barth syndrome rather than merely addressing the symptoms."

MITO Stealth Biotherapeutics
$13.22

(0.00%)

03/12/19
EVER
03/12/19
INITIATION
Target $35
EVER
Outperform
Stealth Biotherapeutics initiated with an Outperform at Evercore ISI
Evercore ISI initiated Stealth Biotherapeutics with an Outperform and $35 price target.
03/12/19
NOMU
03/12/19
INITIATION
Target $23
NOMU
Buy
Stealth Biotherapeutics initiated with a Buy at Nomura Instinet
Nomura Instinet analyst Christopher Marai started Stealth Biotherapeutics with a Buy rating and $23 price target.
03/12/19
JEFF
03/12/19
INITIATION
Target $16
JEFF
Hold
Stealth Biotherapeutics initiated with a Hold at Jefferies
Jefferies analyst Maury Raycroft started Stealth Biotherapeutics with a Hold rating and $16 price target. Elamipretide has a unique mechanism that should help treat a range of severe diseases of the mitochondria and potentially the eye, Raycroft tells investors in a research note. However, he believes the stock rally post the initial public offering has reached a fair price.
03/12/19
03/12/19
INITIATION

Fly Intel: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Snap (SNAP) initiated with an Overweight at Consumer Edge. 2. Crinetics (CRNX) initiated with an Overweight at Cantor Fitzgerald. 3. Tellurian (TELL) initiated with a Buy at BTIG. 4. Stealth Biotherapeutics (MITO) initiated with an Outperform at Evercore ISI, a Buy at Nomura Instinet, and a Hold at Jefferies. 5. Resideo (REZI) initiated with an Outperform at Imperial Capital. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.

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