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WVE

Wave Life Sciences

$24.54

-9.51 (-27.93%)

07:19
04/17/19
04/17
07:19
04/17/19
07:19

Wave Life Sciences price target lowered to $33 from $49 at H.C. Wainwright

H.C. Wainwright analyst Debjit Chattopadhyay lowered his price target for Wave Life Sciences to $33 from $49 following the first look at the company's stereopure isomer platform with a preliminary read on safety and dose for the planned Phase 2/3 program from patients amenable to exon 51 skipping. The analyst believes Wave has a "lot to prove" with limited near-term catalysts. Nonetheless, he keeps a Buy rating on the stock.

WVE Wave Life Sciences
$24.54

-9.51 (-27.93%)

04/16/19
LEER
04/16/19
NO CHANGE
LEER
Outperform
Wave Life Sciences suvodirsen data with little read-through for efficacy, says SVB Leerink
SVB Leerink analyst Mani Foroohar says that Wave Life Sciences' first-in-human safety data from the Phase I trial of suvodirsen in exon 51 skipping-amenable Duchenne Muscular Dystrophy shows that it was generally sage and well-tolerated up to the 5mg/kg dose, and notes the company has selected the 3.0mg/kg and 4.5mg/kg doses to pivotal trials. While the stock is trading down and investors seem to see negative read-throughs for the potential efficacy of suvodirsen at 5mg/kg, given that drisapersen was dosed at 6mg/kg in clinical trials, the analyst believes that due to differences in chemistry between the compounds, comparison of doses between drugs is not appropriate proxy of potential efficacy. Foroohar maintains his 30% probability of success on the suvodirsen program and reiterates an Outperform rating on the shares.
04/16/19
MZHO
04/16/19
NO CHANGE
Target $65
MZHO
Buy
Safety data from Wave Life's Exon-51 SAD DMD trial seems reasonably clean, says Mizuho
Mizuho analyst Salim Syed notes that Wave Life Sciences disclosed safety data from its Phase 1 Exon-51 SAD DMD trial, and based on this Phase 1 trial and preclinical work, the company has selected two doses to move forward into its Phase 2/3 trial, 3mg/kg and 4.5mg/kg. The analyst believes the safety data seems "reasonably clean," and that the Street should be not be getting hung up on the reported adverse events. Syed reiterates a Buy rating and $65 price target on the shares.
04/16/19
STFL
04/16/19
DOWNGRADE
STFL
Hold
Wave Life Sciences downgraded to Hold from Buy at Stifel
04/16/19
04/16/19
DOWNGRADE

Hold
Wave Life Sciences downgraded to Hold from Buy at Stifel
As previously reported, Stifel analyst Paul Matteis downgraded Wave Life Sciences to Hold from Buy, and reduced his target price on shares to $26 from $53. The analyst believes the company's Duchenne muscular dystrophy, or DMD, update from this morning "raises concerns around suvodirsen and more broadly, the degree to which leveraging stereochemistry will lead to a differentiated ASO-based medicines." While Matteis still sees Huntington's disease as a potential source of upside for the stock, the "recent delay -- especially in light of the DMD update this morning -- has reduced [the analyst's] level of conviction in Wave management's execution and the bull-case on its platform/technology."

TODAY'S FREE FLY STORIES

FB

Facebook

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3.29 (1.85%)

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ROKU

Roku

$58.20

1.51 (2.66%)

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TCFC

Community Financial

$28.96

0.06 (0.21%)

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NTAP

NetApp

$76.64

-1.07 (-1.38%)

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RTRX

Retrophin

$19.99

-0.08 (-0.40%)

15:51
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Retrophin management to meet with Jefferies »

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BDRBF

Bombardier

$0.00

(0.00%)

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DHI

D.R. Horton

$45.61

-0.815 (-1.76%)

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  • 25

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NBL

Noble Energy

$27.78

0.66 (2.43%)

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Noble Energy raises quarterly dividend 9% to 12c per share »

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RMBS

Rambus

$11.82

-0.08 (-0.67%)

15:34
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Options
Rambus options imply 9.7% move in share price post-earnings, above median historical move »

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TSLA

Tesla

$263.63

-9.62 (-3.52%)

, SSNLF

Samsung

$0.00

(0.00%)

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Tesla

$263.63

-9.62 (-3.52%)

SSNLF

Samsung

$0.00

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  • 22

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SBUX

Starbucks

$75.23

-0.84 (-1.10%)

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  • 25

    Apr

WHR

Whirlpool

$139.79

0.75 (0.54%)

15:19
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Options
Whirlpool options imply 10.3% move in share price post-earnings, above median historical move »

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TSLA

Tesla

$263.10

-10.15 (-3.71%)

, NVDA

Nvidia

$188.97

2.71 (1.46%)

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Tesla able to make more specific solution than Nvidia, CEO Musk says »

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NVDA

Nvidia

$188.97

2.71 (1.46%)

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$NSD

NASDAQ Market Internals

$0.00

(0.00%)

15:17
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NASDAQ market internals summary »

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$NYE

NYSE Market Internals

$0.00

(0.00%)

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NYSE market internals summary »

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TSLA

Tesla

$263.15

-10.1 (-3.70%)

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All Tesla cars being produced have all necessary for full self-driving »

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WILC

G. Willi-Food

$8.30

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ZION

Zions Bancorp

$46.77

-0.54 (-1.14%)

15:04
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Options
Zions Bancorp options imply 4.1% move in share price post-earnings, above median historical move »

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  • 22

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CGC

Canopy Growth

$47.98

3.55 (7.99%)

15:00
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Options
Buyers gobble up Canopy Growth calls as shares light up »

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TSLA

Tesla

$264.00

-9.25 (-3.39%)

14:59
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Tesla highlights security of FSD computer »

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TSLA

Tesla

$263.58

-9.67 (-3.54%)

14:54
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'Any part could fail,' car will keep driving, Tesla CEO says »

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TSLA

Tesla

$263.56

-9.69 (-3.55%)

14:52
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  • 22

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QEP

QEP Resources

$8.06

0.03 (0.37%)

14:50
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Options
Bullish option play in QEP Resources ahead of earnings »

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  • 25

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RRC

Range Resources

$9.75

-0.01 (-0.10%)

14:49
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14:49
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Options
Range Resources options imply 9.6% move in share price post-earnings, above median historical move »

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  • 23

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LIFE

aTyr Pharma

$0.52

-0.0184 (-3.39%)

14:48
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Federated Investors reports 16.16% passive stake in aTyr Pharma »

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