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ONCS

OncoSec

$0.61

-0.0383 (-5.91%)

08:05
04/17/19
04/17
08:05
04/17/19
08:05

OncoSec signs collaborative research agreement for Tavoplus in breast cancer

OncoSec have entered into a collaborative research agreement to evaluate the use of OncoSec's proprietary Tavoplus enhanced IL-12 DNA-plasmid in combination or sequence with a HER2-plasmid vaccine administered with OncoSec's intratumoral delivery system. OncoSec will provide its proprietary Tavo and its new electroporation generator, Apollo, using lower voltage and a longer pulse width which greatly increased DNA-plasmid cellular transfection rates, to Duke University's Center for Applied Therapeutics. Duke University investigators will conduct preclinical studies using plasmid vaccines targeting HER2 in combination with plasmid vaccines and TAVO in a newly developed endogenous mouse model of HER2+ breast cancer. Additionally, Duke investigators will use Tavo with their high-intensity ultrasound tumor ablation models to explore the impact of IL-12 delivery on the development of systemic immunity.

ONCS OncoSec
$0.61

-0.0383 (-5.91%)

11/06/18
PIPR
11/06/18
NO CHANGE
Target $3
PIPR
Overweight
OncoSec price target lowered to $3 from $5 at Piper Jaffray
After OncoSec (ONCS) reported preliminary Phase 2b KEYNOTE-695 data for Tavo combined with Merck's (MRK) Keytruda in PD-1 refractory melanoma patients, Piper Jaffray analyst Edward Tenthoff said the data, while early, show evidence of clinical activity, adding that he believes duration of response data will be important. However, OncoSec shares are down 52% today, which Tenthoff attributes to the lower response rate compared to prior data in different patients. The analyst keeps an Overweight rating on OncoSec shares, but lowered his price target on the stock to $3 from $5 as he pushed out his approval projections for Tavo by one year in the U.S. and Europe.
11/07/18
HCWC
11/07/18
DOWNGRADE
Target $1
HCWC
Neutral
OncoSec downgraded to Neutral from Buy at H.C. Wainwright
H.C. Wainwright analyst Raghuram Selvaraju downgraded OncoSec to Neutral from Buy after the company reported preliminary top-line data from the PISCES/KEYNOTE-695 trial of TAVO with Keytruda in metastatic melanoma patients who have failed anti-PD-1 therapy, stating that his first impression is that the early efficacy results are "underwhelming." He noted that other second generation I/O agents have demonstrated higher response rates and while TAVO may eventually obtain regulatory approval, its efficacy may not be differentiated enough for wide market adoption. Selvaraju lowered his price target on OncoSec shares to $1 from $4.
12/12/18
PIPR
12/12/18
NO CHANGE
Target $3
PIPR
Overweight
Piper reiterates Overweight, $3 target on OncoSec after data
Piper Jaffray analyst Edward Tenthoff believes OncoSec Medical's updated six-month response data from the Phase IIb Keynote-695 data of tavo plus Keytruda in PD-1 refractory melanoma demonstrate tavo's ability to deepen tumor response over time. The analyst reiterates an Overweight rating on OncoSec with a $3 price target.
02/01/19
PIPR
02/01/19
NO CHANGE
Target $3
PIPR
Overweight
Piper says OncoSec's TAVO resensitizing anti-PD-1 progressers 'impressive'
After OncoSec (ONCS) reported updated data for the registrational KEYNOTE-695 study evaluating TAVO plus Merck's (MRK) Keytruda, Piper Jaffray analyst Edward Tenthoff noted that TAVO's ORR improved and called the fact that TAVO resensitized anti-PD-1 progressers "impressive." He reiterates an Overweight and $3 price target on OncoSec shares.

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