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PCRX

Pacira

$46.56

-0.24 (-0.51%)

07:46
05/07/19
05/07
07:46
05/07/19
07:46

Pacira announces full results from Phase 4 Exparel study

Pacira announced that full results from its Phase 4 study of Exparel administered via transversus abdominis plane, or TAP, field block in patients undergoing Cesarean section. Exparel achieved its primary endpoint with a statistically significant reduction in total postsurgical opioid consumption through 72 hours. Exparel also achieved statistical significance for reduction in pain intensity scores through 72 hours. The data were presented from the podium at the Society of Obstetric Anesthesia and Perinatology, or SOAP. This was a multicenter, randomized, double-blind study across 13 clinical sites in the United States, enrolling 186 patients undergoing elective C-section and receiving spinal anesthesia. Patients were randomized to receive Exparel 266 mg plus bupivacaine HCl 50 mg or bupivacaine HCl 50 mg alone administered via TAP field block after surgery. Efficacy was evaluated in a pre-specified modified intent-to-treat, or mITT, population who met study protocol criteria regarding proper administration of TAP and multimodal regimen. The study found significant reduction in total opioid consumption with Exparel plus bupivacaine HCl versus bupivacaine HCl, lower cumulative pain scores through 72 hours with Exparel versus bupivacaine HCl and higher percentage of opioid-spared patients with Exparel versus bupivacaine HCl. Safety was comparable between groups in this study, with 64% of patients in the Exparel group experiencing a treatment-emergent adverse event, or TEAE, versus 56% of patients in the bupivacaine HCl group. The most common TEAEs were pruritus and nausea; serious TEAEs were rare. There were no fatal TEAEs.

  • 30

    May

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    Jun

PCRX Pacira
$46.56

-0.24 (-0.51%)

03/08/19
STFL
03/08/19
NO CHANGE
Target $33
STFL
Sell
Pacira price target lowered to $33 from $41 at Stifel
Stifel analyst Derek Archila lowered his price target on Pacira (PCRX) shares to $33 and reiterated a Sell rating on the stock, stating that the company's 22% year-over-year growth guidance for Exparel "is no lay-up" and he sees meaningful competitive pressure coming from Heron Therapeutics' (HRTX) HTX-011 and its expected positive news flow ahead of launch. While MyoScience's Iovera seems like it will fit very well within Pacira's current sales infrastructure, the acquisition of MyoScience "was certainly not the deal investors were looking for," added Archila.
05/02/19
STFL
05/02/19
UPGRADE
STFL
Hold
Pacira upgraded to Hold from Sell at Stifel
05/02/19
STFL
05/02/19
UPGRADE
Target $45
STFL
Hold
Stifel upgrades Pacira to Hold after Heron competition delayed
As previously reported, Stifel analyst Derek Archila upgraded Pacira (PCRX) to Hold from Sell after Heron Therapeutics (HRTX) announced yesterday that it received a Complete Response Letter from the FDA for its New Drug Application for HTX-011 for the management of postoperative pain. Archila now forecasts HTX-011's approval and launch in 2020 and thinks Pacira's Exparel will likely remain the only local, non-opioid, long-acting analgesic on the market through the remainder of 2019. He also believes a recent price increase and a favorable reimbursement scheme in the ASC setting should set the company up to achieve its 2019 Exparel guidance. However, Archila said key points from his Sell thesis still worry him long-term as he thinks other more competitive offerings, from Heron and others, will eventually come to market. Given his increased Exparel forecast and the incorporation of the recent acquisition of Iovera, Archila raised his price target on Pacira shares to $45 from $33.
05/06/19
MZHO
05/06/19
UPGRADE
Target $38
MZHO
Neutral
Pacira upgraded to Neutral from Underperform at Mizuho
Mizuho analyst Irina Koffler upgraded Pacira Biosciences (PCRX) to Neutral from Underperform and raised her price target for the shares to $38 from $29. The analyst says her sell thesis on the shares is longer valid due to an unexpected delay at competitor Heron Therapeutics (HRTX) and Pacira's stronger guidance on recently acquired iovera. However, she still remains concerned about the longer-term outlook for the company.

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UBER

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MYOV

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MYOV

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