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NVS

Novartis

$81.07

-1.72 (-2.08%)

13:58
05/07/19
05/07
13:58
05/07/19
13:58

Novartis reports interim long-term follow-up data from Phase 1 START trial

AveXis, a Novartis company, announced interim long-term follow-up data from the Phase 1 START trial of the investigational product Zolgensma that showed durability of the gene therapy in patients with spinal muscular atrophy, or SMA, Type 1 nearly four years after treatment. These data were presented during the 2019 American Academy of Neurology Annual Meeting, the company noted. As of March 8, 2019, all patients maintained the motor function and milestones gained during the trial following treatment with Zolgensma. In addition, no patients had any additional requirements for ventilatory or nutritional support. Two of the four patients who required Bilevel Positive Airway Pressure support at the beginning of the long-term follow-up study no longer required it regularly. No new treatment-related adverse events have emerged during the follow-up period. Patients in START were treated with gene therapy alone during the 24-month study duration. In the long-term follow-up study, 7 of 10 patients remain on monotherapy alone. Initiation of combination therapy was at parental and physician discretion and was not due to loss of motor function, the company said.

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NVS Novartis
$81.07

-1.72 (-2.08%)

04/25/19
04/25/19
UPGRADE

Fly Intel: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Facebook (FB) upgraded to Buy from Neutral at UBS with analyst Eric Sheridan saying while 2019 remains a year of transition, Facebook management has now produced multiple quarters of better than expected revenue and earnings. 2. American Express (AXP) upgraded to Overweight from Equal Weight at Morgan Stanley with analyst Betsy Graseck saying she believes its strong revenue growth remains intact given its record growth in proprietary cards, strong contribution from Millennials, fee-based products and its strong loan and transactional growth. 3. Novartis (NVS) upgraded to Buy from Neutral at Guggenheim with analyst Seamus Fernandez saying he is more confident that the company "can deliver several years of mid-single digit operating profit and EPS growth" through 2024. 4. Sirius XM (SIRI) upgraded to Buy from Hold at Pivotal Research with analyst Jeffrey Wlodarczak saying yesterday's post-earnings selloff was overdone as investors overreacted to slightly lower than expected new car installations and modestly lower than expected self-pay net subscriber additions. 5. General Dynamics (GD) upgraded to Neutral from Underweight at JPMorgan with analyst Seth Seifman saying General Dynamics has underperformed the market by~21% since the start of 2018. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
05/01/19
WELS
05/01/19
NO CHANGE
Target $18
WELS
Market Perform
Teva shares reflect much of bad news, says Wells Fargo
Wells Fargo analyst David Morris kept his Market Perform rating and $18 price target on Teva (TEVA) ahead of its Q1 earnings tomorrow, saying investors have "low expectations" for the quarter after "weak-ish" Sandoz results from Novartis (NVS). The analyst also points to IQVIA (IQV) sales and prescriptions data indicating that Teva generic sales were down 12% in March, 10% in February, and 13% in January, though the decline are "much smaller" than seen in U.S. generics during 2018. Morris further expects Teva to address the risk of opioid litigation that became a concern during the quarter in its earnings call.
05/02/19
FBCO
05/02/19
INITIATION
Target $66
FBCO
Outperform
Alcon initiated with an Outperform at Credit Suisse
Credit Suisse analyst Matt Miksic started coverage of Alcon (ALC) with an Outperform rating and a $66 price target. Recently spun off from parent Novartis (NVS), Alcon is now positioned to deliver improving growth and margins, the analyst contends. Miksic believes the key to the Alcon investment case is the opportunity to increase revenue growth and margins through expanded market share and its leadership positions in cataract, retinal surgery, contact lenses and consumer eye care.
05/07/19
MSCO
05/07/19
NO CHANGE
MSCO
Biogen could rise, or fall, 5% based on Zolgensma label, says Morgan Stanley
Morgan Stanley analyst Matthew Harrison noted that Novartis' (NVS) gene therapy for the rare disease spinal muscular atrophy, Zolgensma, is expected to be approved by the FDA this month. He also noted that Biogen's (BIIB) Spinraza is currently the only approved drug for SMA and represents 17% of Biogen's estimated 2019 sales. The public data for Novartis' Zolgensma are only in type 1 patients, or infants, said Harrison, who sees three potential scenarios for the drug's label. In the first, which would involve broad approval across the three patient classes of infants, children and adults, Harrison thinks Novartis shares could be up 1-2%, Biogen could fall about 5%, Ionis (IONS), which receives royalties from Biogen, could be down about 10%, and Regenxbio (RGNX), which will receive royalties from Novartis, could be up 10-15% or more. In the second case, where Zolgensma is granted a Type 1 approval with no restriction, Harrison sees Novartis unchanged, Biogen down 1-3%, Ionis falling 3-5% and Regenxbio rising 5%. In the third scenario, where Zolgensma gets a Type 1 approval but with a weight/age restriction, the analyst thinks Novartis would be down 1-2%, Biogen would be up 2-3%, Ionis could rise 5% and Regenxbio could fall 5-10%. Harrison's base case assumption is that Zolgensma will ultimately capture the majority market share in type 1 patients and a "significant portion" of type 2, or pediatric, patients.

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Uber

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0.94 (2.32%)

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APTO

Aptose Biosciences

$2.01

0.03 (1.52%)

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TRNX

Taronis Technologies

$0.48

0.004 (0.84%)

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USEG

U.S. Energy

$0.45

0.0373 (9.10%)

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AAPL

Apple

$179.03

-0.64 (-0.36%)

17:22
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SPCB

SuperCom

$1.17

-0.005 (-0.43%)

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USEG

U.S. Energy

$0.45

0.0373 (9.10%)

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MYOV

Myovant Sciences

$12.39

-0.465 (-3.62%)

17:18
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Syndicate
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MYOV

Myovant Sciences

$12.39

-0.465 (-3.62%)

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NVS

Novartis

$87.49

3.03 (3.59%)

, QGEN

Qiagen

$38.22

-0.255 (-0.66%)

16:57
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NVS

Novartis

$87.49

3.03 (3.59%)

QGEN

Qiagen

$38.22

-0.255 (-0.66%)

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AVH

Avianca

$3.96

0.91 (29.84%)

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Periodicals
ANAC suspends flights, operations of Avianca Brasil, Reuters reports »

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AAPL

Apple

$179.03

-0.64 (-0.36%)

16:53
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Periodicals
Apple acquires startup Tueo Health, CNBC reports »

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SHSP

SharpSpring

$16.37

-0.24 (-1.44%)

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Syndicate
Breaking Syndicate news story on SharpSpring »

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CREG

China Recycling Energy

$0.48

0.005 (1.05%)

16:41
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Syndicate
Breaking Syndicate news story on China Recycling Energy »

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FENC

Fennec

$3.88

(0.00%)

16:36
05/24/19
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16:36
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16:36
Conference/Events
Fennec management to meet with Wedbush »

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TD

Toronto-Dominion

$56.66

0.65 (1.16%)

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Options
Preliminary option volume of 15.7M today »

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CBUS

Cibus

$0.00

(0.00%)

16:25
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BA

Boeing

$355.14

4.57 (1.30%)

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FB

Facebook

$181.03

0.14 (0.08%)

, BA

Boeing

$355.14

4.57 (1.30%)

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FB

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$181.03

0.14 (0.08%)

BA

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$355.14

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UAL

United Continental

$80.77

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SMI

SMIC

$5.23

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HPQ

HP Inc.

$20.03

0.835 (4.35%)

HPE

HP Enterprise

$14.36

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NVS

Novartis

$87.49

3.03 (3.59%)

CNC

Centene

$56.84

1.39 (2.51%)

WCG

WellCare

$275.45

0.99 (0.36%)

TSS

TSYS

$113.42

13.81 (13.86%)

GPN

Global Payments

$153.42

5.45 (3.68%)

HIBB

Hibbett Sports

$23.91

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DVAX

Dynavax

$5.77

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FL

Foot Locker

$44.39

-8.455 (-16.00%)

SPLK

Splunk

$119.13

-9.55 (-7.42%)

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VIX

Volatility Index S&P 500 Options

$0.00

(0.00%)

16:20
05/24/19
05/24
16:20
05/24/19
16:20
Options
Closing CBOE SPX and VIX Index summary for May 24th »

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$NSD

NASDAQ Market Internals

$0.00

(0.00%)

16:17
05/24/19
05/24
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16:17
Technical Analysis
NASDAQ market internals summary »

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$NYE

NYSE Market Internals

$0.00

(0.00%)

16:16
05/24/19
05/24
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16:16
Technical Analysis
NYSE market internals summary »

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RHE

Regional Health Properties

$2.06

0.09 (4.57%)

16:15
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Hot Stocks
Regional Health Properties receives NYSE notice over late Form 10-Q filing »

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TBIO

Translate Bio

$9.12

-0.09 (-0.98%)

16:14
05/24/19
05/24
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Syndicate
Breaking Syndicate news story on Translate Bio »

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  • 18

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