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PTGX

Protagonist Therapeutics

$10.49

-0.2 (-1.87%)

07:04
05/14/19
05/14
07:04
05/14/19
07:04

Protagonist Therapeutics: Administration of PN-943 was 'safe and well tolerated'

Protagonist Therapeutics announced results from the initial single ascending dose part of the Phase 1 study of PN-943, an oral, gut-restricted alpha-4-beta-7 integrin specific antagonist in development for the potential treatment of inflammatory bowel disease. Results of the first clinical study of PN-943 in a randomized, double-blind, placebo-controlled, dose escalation study in healthy volunteers demonstrated that administration of PN-943 was safe and well tolerated, with no reported serious adverse events. The pharmacokinetic and pharmacodynamic parameters were consistent with the design of PN-943 as a gastrointestinal-restricted alpha-4-beta-7 integrin antagonist. "These dose-finding results are consistent with the preclinical properties of PN-943, including superior target engagement as compared with prior compound PTG-100," commented Samuel Saks, M.D., Protagonist Chief Medical Officer. "PN-943 has been designed with superior potency and a longer half-life of dissociation. In addition, PN-943 applies the oral, gut-restricted, integrin antagonist approach that has been validated by previous studies in ulcerative colitis patients with PTG-100."

  • 07

    Jun

PTGX Protagonist Therapeutics
$10.49

-0.2 (-1.87%)

02/21/19
BMOC
02/21/19
INITIATION
BMOC
Outperform
Protagonist Therapeutics initiated with an Outperform at BMO Capital
BMO Capital analyst George Farmer initiated Protagonist Therapeutics with an Outperform rating and $17 price target. Farmer said the recent stock pullback offers an attractive entry point based on the potential of the company's "novel peptide chemistry platform," and that positive outcomes of upcoming catalysts this year could drive shares close to $17 per share.
05/08/19
STFL
05/08/19
UPGRADE
Target $17
STFL
Buy
Protagonist Therapeutics upgraded to Buy from Hold at Stifel
Stifel analyst Adam Walsh upgraded Protagonist Therapeutics to Buy from Hold and raised his price target for the shares to $17 from $11.
05/09/19
STFL
05/09/19
UPGRADE
Target $17
STFL
Buy
Stifel upgrades Protagonist Therapeutics to Buy after Janssen opts in
Stifel analyst Adam Walsh last night upgraded Protagonist Therapeutics to Buy from Hold and raised his price target for the shares to $17 from $11. The expansion of the deal between Protagonist and Janssen for PTG-200 and other IL-23 receptor antagonists brings large pharma validation to the former's oral peptide platform, Walsh tells investors in a research note. The analyst now has increased confidence in PTG-200. Janssen's decision to opt-in to further PTG-200 development is supportive of PTG-200's potential in Crohn's and should assuage investor fears around Protagonist's oral peptide technology, says the analyst.
05/09/19
05/09/19
UPGRADE

Fly Intel: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Atlassian (TEAM) upgraded to Buy from Neutral at Goldman Sachs with Heather Bellini saying consensus billings expectations for Q4 of $361M, or up 30% year-over-year, appear conservative. 2. Match Group (MTCH) upgraded to Neutral from Sell at Goldman Sachs with 3ith analyst Michael Ng stating that the positive stock reaction to Match's in-line Q1 revenue and EBITDA results illustrate the market is more focused on the longer-term investment thesis. 3. Protagonist Therapeutics (PTGX) upgraded to Buy from Hold at Stifel with analyst Adam Walsh saying yhe expansion of the deal between Protagonist and Janssen for PTG-200 and other IL-23 receptor antagonists brings large pharma validation to the former's oral peptide platform. 4. Penn National (PENN) upgraded to Buy from Neutral at BofA/Merrill with analyst Shaun Kelley stating that its core consumer remains stable and he believes catalysts such as the relaunch of MyChoice and sports betting are being underappreciated by investors. 5. Ferrari (RACE) upgraded to Overweight from Equal Weight at Morgan Stanley with analyst Adam Jonas noting the company's better than expected Q1 results and saying he has higher conviction in the company's strategy. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

UBER

Uber

$41.40

0.94 (2.32%)

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APTO

Aptose Biosciences

$2.01

0.03 (1.52%)

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TRNX

Taronis Technologies

$0.48

0.004 (0.84%)

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USEG

U.S. Energy

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0.0373 (9.10%)

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AAPL

Apple

$179.03

-0.64 (-0.36%)

17:22
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  • 03

    Jun

SPCB

SuperCom

$1.17

-0.005 (-0.43%)

17:21
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USEG

U.S. Energy

$0.45

0.0373 (9.10%)

17:20
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MYOV

Myovant Sciences

$12.39

-0.465 (-3.62%)

17:18
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MYOV

Myovant Sciences

$12.39

-0.465 (-3.62%)

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NVS

Novartis

$87.49

3.03 (3.59%)

, QGEN

Qiagen

$38.22

-0.255 (-0.66%)

16:57
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NVS

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$87.49

3.03 (3.59%)

QGEN

Qiagen

$38.22

-0.255 (-0.66%)

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  • 24

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AVH

Avianca

$3.96

0.91 (29.84%)

16:56
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ANAC suspends flights, operations of Avianca Brasil, Reuters reports »

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AAPL

Apple

$179.03

-0.64 (-0.36%)

16:53
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  • 03

    Jun

SHSP

SharpSpring

$16.37

-0.24 (-1.44%)

16:52
05/24/19
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  • 13

    Jun

CREG

China Recycling Energy

$0.48

0.005 (1.05%)

16:41
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Breaking Syndicate news story on China Recycling Energy »

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FENC

Fennec

$3.88

(0.00%)

16:36
05/24/19
05/24
16:36
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16:36
Conference/Events
Fennec management to meet with Wedbush »

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  • 29

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    Jun

TD

Toronto-Dominion

$56.66

0.65 (1.16%)

16:35
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16:30
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CBUS

Cibus

$0.00

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16:25
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BA

Boeing

$355.14

4.57 (1.30%)

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FB

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UAL

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HPQ

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HPE

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CNC

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DVAX

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VIX

Volatility Index S&P 500 Options

$0.00

(0.00%)

16:20
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$NSD

NASDAQ Market Internals

$0.00

(0.00%)

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$NYE

NYSE Market Internals

$0.00

(0.00%)

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NYSE market internals summary »

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RHE

Regional Health Properties

$2.06

0.09 (4.57%)

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TBIO

Translate Bio

$9.12

-0.09 (-0.98%)

16:14
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  • 18

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