NuCana reports Q1 EPS GBP (.17) versus GBP (.20) last year
It has been a good start to the year and we are pleased with NuCana's continued progress," said Hugh S. Griffith, NuCana's Founder and Chief Executive Officer. "In February 2019, we announced two abstracts related to NUC-3373 that were selected for presentation at the American Association for Cancer Research Annual Meeting 2019 in April. NUC-3373 is NuCana's second ProTide in clinical development and is a transformation of the active anti-cancer metabolite of 5-fluorouracil, one of the most widely prescribed anti-cancer agents. Our current findings have shown that NUC-3373 has an additional mechanism of action for promoting anti-cancer activity that is independent of the DNA damage pathway. NUC-3373 inhibits the target enzyme, thymidylate synthase, causing nuclear to cytoplasmic translocation and induction of endoplasmic reticulum stress. We look forward to announcing additional data in 2019 from the ongoing Phase I study of NUC-3373, as well as data from the ongoing Phase 1b study of NUC-3373 in combination with other agents typically combined with 5-FU."