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ALNY

Alnylam

$68.77

1.13 (1.67%)

07:06
05/31/19
05/31
07:06
05/31/19
07:06

Alnylam doses first patient in Phase 1 study of ALN-AGT

Alnylam Pharmaceuticals announced that the first patient has been dosed in the Company's Phase 1 study of ALN-AGT, an investigational RNAi therapeutic targeting angiotensinogen, or AGT, for the treatment of hypertension in high unmet need populations, including patients with resistant or refractory hypertension, chronic kidney disease or heart failure. The company expects to report initial results in late 2019.

  • 04

    Jun

ALNY Alnylam
$68.77

1.13 (1.67%)

05/23/19
GSCO
05/23/19
DOWNGRADE
Target $80
GSCO
Neutral
Alnylam assumed with a Neutral from Buy at Goldman Sachs
Goldman Sachs analyst Salveen Richter assumed coverage of Alnylam Pharmaceuticals (ALNY) with a Neutral rating and $80 price target. The firm previously had a Buy rating on the shares. Onpattro, Alnylam's first commercial drug and key value driver, had a positive launch start, but anticipated competitive headwinds from recently approved Pfizer's tafamidis are an overhang on the shares, Richter tells investors in a research note. The analyst is on the sidelines as he assesses the drug's competitive landscape.
05/20/19
NOMU
05/20/19
NO CHANGE
Target $62
NOMU
Reduce
Alnylam partner presented limited safety data, says Nomura Instinet
Alnylam Pharmaceuticals' (ALNY) partner, the Medicines Company (MDCO), presented on Saturday data from the ORION-3 trial of inclisiran, Nomura Instinet analyst Christopher Marai tells investors in a research note. The update did not suggest any surprise safety signals, as expected, but only limited safety data, according to Marai. He believes inclisiran's opportunity is a "show-me story" and more likely to become priced in post-approval after material sales. The analyst reiterates a Reduce rating on Alnylam shares with a $62 price target.
05/07/19
PIPR
05/07/19
NO CHANGE
Target $142
PIPR
Overweight
Piper more confident in estimates for Alnylam's Onpattro after doctor survey
Piper Jaffray analyst Edward Tenthoff reiterates an Overweight rating on Alnylam Pharmaceuticals (ALNY) with a $142 price target after surveying 16 physicians treating 490 hereditary transthyretin amyloidosis patients with polyneuropathy. Doctors have a "clear preference" for Alnylam's Onpattro over Onpattro and Ionis Pharmaceuticals' (IONS) Tegsedi, with efficacy, safety, and experience being cited, Tenthoff tells investors in a research note. Roughly two-thirds of existing and new gene silencer patients are prescribed Onpattro, says the analyst. Based on the survey results, the analyst is increasingly confident in his 2019 Onpattro sales estimates of $127M.
05/01/19
PIPR
05/01/19
NO CHANGE
Target $142
PIPR
Overweight
Alnylam shares reacting to increased expense guidance, says Piper Jaffray
Piper Jaffray analyst Edward Tenthoff noted that Alnylam reported Q1 Onpattro sales of $26M, which beat his $14M estimate and the consensus forecast of $19M. Despite the Onpattro sales beat and trends that he said underscore the drug's "best-in-class profile," Tenthoff said the stock is reacting negatively to management having increased their 2019 expense guidance. The analyst, who raised his 2019 Onpattro sales forecast to $127M from $82M, keeps an Overweight rating and $142 price target on Alnylam. Near 11 am ET, Alnylam shares are down 4% to $85.49.

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AAPL

Apple

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DELL

Dell Technologies

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1.88 (3.65%)

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HPQ

HP Inc.

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GNCA

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PSNL

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CYRX

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  • 20

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VTR

Ventas

$69.65

1.05 (1.53%)

20:41
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HSY

Hershey

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-0.29 (-0.21%)

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KR

Kroger

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-0.3 (-1.25%)

, DRI

Darden

$117.55

-0.39 (-0.33%)

20:25
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Earnings
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Darden

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DAL

Delta Air Lines

$56.38

0.33 (0.59%)

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SPY

SPDR S&P 500 ETF Trust

$293.02

0.69 (0.24%)

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$0.00

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ARZGY

Generali

$0.00

(0.00%)

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19:22
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Generali rating change at JPMorgan »

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GO

Grocery Outlet

$0.00

(0.00%)

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Grocery Outlet 17.19M share IPO priced at $22.00 »

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WIX

Wix.com

$145.83

1.19 (0.82%)

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AOBC

American Outdoor Brands

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TMUS

T-Mobile

$78.28

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, S

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TMUS

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S

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ZBRA

Zebra Technologies

$200.57

-1.1 (-0.55%)

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ZBRA

Zebra Technologies

$200.57

-1.1 (-0.55%)

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UNH

UnitedHealth

$250.25

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  • 18

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SRRK

Scholar Rock

$17.11

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  • 20

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QDEL

Quidel

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DELL

Dell Technologies

$53.39

1.88 (3.65%)

, HPQ

HP Inc.

$20.63

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MSFT

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ORCL

Oracle

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  • 19

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CB

Chubb

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