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XNCR

Xencor

$30.86

-0.89 (-2.80%)

08:08
06/03/19
06/03
08:08
06/03/19
08:08

Xencor doses first patient in Phase 1 study of XmAb22841

Xencor announced that the first patient has been dosed in a Phase 1 clinical study to evaluate the safety and tolerability of XmAb22841, both as a monotherapy and in combination with pembrolizumab, in patients with advanced solid tumors. XmAb22841 is a bispecific antibody that simultaneously targets the immune checkpoint receptors CTLA-4 and LAG-3. The Phase 1 dose-escalation and expansion study, which explores XmAb22841 as a monotherapy and in combination with pembrolizumab will characterize the safety and tolerability, pharmacokinetics, pharmacodynamics, immunogenicity and preliminary anti-tumor activity of intravenous administration in patients with select advanced solid tumors.

  • 26

    Jun

XNCR Xencor
$30.86

-0.89 (-2.80%)

02/26/19
PIPR
02/26/19
NO CHANGE
Target $56
PIPR
Overweight
Xencor price target raised to $56 from $52 at Piper Jaffray
Piper Jaffray analyst Edward Tenthoff raised his price target for Xencor to $56 after the company ended 2018 with cash of $530.5M and subsequently received $120M upfront from the Genentech bispecific cytokine deal. In addition, Xencor announced its intention to partner obexelimab based on positive Phase II IgG4-related disease and lupus data, Tenthoff tells investors in a research note. And importantly, the company is working with the FDA to resolve the partial clinical hold on XmAb14045 in relapsed/refractory acute myeloid leukemia, adds the analyst. He reiterates an Overweight rating on Xencor.
03/14/19
RAJA
03/14/19
INITIATION
Target $40
RAJA
Outperform
Xencor initiated with an Outperform at Raymond James
Raymond James analyst Dane Leone initiated Xencor with an Outperform rating and a price target of $40, citing the company's "multiple programs and development partnerships across a range of therapeutic indications." The analyst contends that the next 12 months will be a "clinical inflection point for the wholly owned bi-specific antibody programs targeting oncology", adding that he is "optimistic that the current partial hold on the Xmab14045 program could be lifted near-term". Leone further notes that his sales model does not account for obexelimab until a partnership has been established, but he is "optimistic for a partnership to occur within the next 12 months".
03/27/19
BREN
03/27/19
INITIATION
Target $45
BREN
Buy
Xencor initiated with a Buy at Berenberg
Berenberg analyst Shanshan Xu initiated Xencor with a Buy and $45 price target saying he sees a turning point ahead following a setback earlier this year due to the partial clinical hold on onf of its CD3 T-cell bispecific antibodies. Xu believes the ramp of Ultomiris royalties and the potential positive data and regulatory approval of MOR-208 will validate Xencor's platform and increase confidence in its broader pipeline, providing a door for further partnerships.
04/12/19
GUGG
04/12/19
INITIATION
Target $42
GUGG
Buy
Xencor initiated with a Buy at Guggenheim
Guggenheim analyst Michael Schmidt started Xencor with a Buy rating and $42 price target. The company has a "deep" clinical pipeline of bispecific T-cell engagers and dual checkpoint / co-stimulatory antibodies with early clinical data readouts through the second half of 2019 that represent potential upside, Schmidt tells investors in a research note.

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