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GILD

Gilead

$62.26

-1.08 (-1.71%)

09:06
06/03/19
06/03
09:06
06/03/19
09:06

Kite announces new Yescarta data from ZUMA-1

Kite, a Gilead Company, announced findings from two new analyses from the ZUMA-1 trial of Yescarta in adult patients with relapsed or refractory large B-cell lymphoma. These results include a two-year sub-population analysis of efficacy and safety in ZUMA-1 patients by age, as well as preliminary data from a separate safety management study of patients receiving early steroid intervention for cytokine release syndrome and neurologic events. The results were presented at the 2019 American Society of Clinical Oncology Annual Meeting. Yescarta was the first CAR T cell therapy approved by the U.S. Food and Drug Administration for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, including diffuse large B-cell lymphoma not otherwise specified, primary mediastinal large B-cell lymphoma, high grade B-cell lymphoma and DLBCL arising from follicular lymphoma. Yescarta is not indicated for the treatment of patients with primary central nervous system lymphoma. Two-Year Analysis of ZUMA-1 by Age Supports Clinical Benefit of Yescarta in Patients 65 and Older: Patients with relapsed large B-cell lymphoma in the two-year follow-up of ZUMA-1 were analyzed in two groups - those 65 years or older and those younger than 65 years. With a median follow-up of 27.1 months, the objective response rate per investigator assessment was 92 percent among greater than or equal to65 patients and 81 percent in the less than65 group, with 75 percent and 53 percent of patients in the respective groups achieving a complete response. At two years, 42 percent of greater than or equal to65 patients and 38 percent of less than65 patients were in an ongoing response. The 24-month overall survival rate was 54 percent and 49 percent in each respective group. Among all patients in the safety analysis, most experienced Grade greater than or equal to3 adverse events. Grade greater than or equal to3 neurologic events occurred in 12 patients greater than or equal to65 and in 23 patients less than65. Grade greater than or equal to3 CRS occurred in 2 patients greater than or equal to65 and in 10 patients less than65. Kite is currently conducting various studies to further evaluate the efficacy and safety profile of Yescarta, including clinical trials evaluating use of bridging chemotherapy and other combination approaches. In a ZUMA-1 safety management study, patients with relapsed or refractory large B-cell lymphoma treated with Yescarta received earlier steroid intervention beginning when patients experienced Grade 1 neurologic events and at Grade 1 CRS when no improvement was observed after three days of supportive care. As of the abstract data cut-off, 21 of 40 planned patients had received Yescarta, with a median follow-up of 7.7 months; 76 percent of patients received corticosteroids and 86 percent received tocilizumab. Grade greater than or equal to3 adverse events occurred in 95 percent of patients; Grade greater than or equal to3 events included decreased neutrophil count and anemia. Grade 1 or 2 neurologic events and CRS occurred in 48 percent and 100 percent of patients, respectively. No patients experienced Grade greater than or equal to3 CRS, and Grade greater than or equal to3 neurologic events occurred in only 10 percent of patients, both numerically lower than in the registrational cohorts of ZUMA-1. There were no deaths due to adverse events in Cohort 4. ORR per investigator assessment was 81 percent in the cohort, and 62 percent of patients achieved a complete response. The median duration of response has not yet been reached.

  • 04

    Jun

GILD Gilead
$62.26

-1.08 (-1.71%)

05/24/19
PIPR
05/24/19
NO CHANGE
Target $11
PIPR
Overweight
Alpine Immune Sciences Kite pact termination 'a win,' says Piper Jaffray
Last week's new collaboration and license agreement between Alpine Immune Sciences (ALPN) with Adaptimmune (ADAP) essentially replaced the old deal between Kite Pharma and Gilead (GILD), termination of which was announced in a regulatory filing earlier today and is driving Alpine shares lower, Piper Jaffray analyst Edward Tenthoff tells investors in a research note to investors. Tenthoff says he sees this as a win for Alpine, who received $2M upfront and is eligible for an additional $288M in milestones, adding that he is a buyer of Alpine Immune Sciences on today's weakness ahead of ALPN-101 safety and biomarker data this quarter. Tenthoff maintains an Overweight rating and $11 price target on Alpine Immune Sciences shares.
05/28/19
GSCO
05/28/19
DOWNGRADE
Target $60
GSCO
Sell
Gilead downgraded to Sell from Neutral at Goldman Sachs
Goldman Sachs analyst Terence Flynn downgraded Gilead Sciences to Sell from Neutral and lowered his price target for the shares to $60 from $70. The analyst sees limited growth and pipeline expansion opportunities.
05/28/19
GSCO
05/28/19
DOWNGRADE
Target $60
GSCO
Sell
Goldman sees negative sales growth for Gilead, downgrades shares to Sell
Goldman Sachs analyst Terence Flynn downgraded Gilead Sciences (GILD) to Sell from Neutral and lowered his price target for the shares to $60 from $70. The analyst expects Gilead's sales growth to decelerate saying the Truvada/Atripla loss of exclusivities in Sept ember 2020 represents a $3B headwind. Further, Biktarvy can only protect about half of the company's $16B HIV franchise from generic competition, Flynn tells investors in a research note. As a result, the analyst models annual revenue growth for Gilead through 2022 as negative 5%, which he notes is among the lowest in his coverage universe. Meanwhile, the stock trades at a slight premium to other stocks such as Bristol-Myers (BMY) and AbbVie (ABBV), says Flynn.
05/28/19
05/28/19
DOWNGRADE

Fly Intel: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Gilead (GILD) downgraded to Sell from Neutral at Goldman Sachs with analyst Terence Flynn saying he expects Gilead's sales growth to decelerate saying the Truvada/Atripla loss of exclusivities in September 2020 represents a $3B headwind. 2. Teva (TEVA) downgraded to Neutral from Buy at UBS with analyst Navin Jacob saying he sees larger potential litigation expense following the company's settlement with Oklahoma as well as later than expected launches on its generic pipeline assets. 3. Weibo (WB) downgraded to Neutral from Overweight at JPMorgan with analyst Binbin Ding sayin ghe sees a worsening advertising outlook in the near-term with "no clear visibility" into the second half of 2019 and 2020. 4. Nutanix (NTNX) downgraded to Equal Weight from Overweight at Morgan Stanley with analyst Katy Huberty saying the combination of slowing industry demand and competition from Dell (DELL) will slow down a full recovery in its business. 5. Roku (ROKU) downgraded to Equal Weight from Overweight at Stephens with analyst Kyle Evans saying though he remains "very positive" on Roku over the long-term, he believes the stock's recently increased valuation combined with raised expectations creates increased near-term risk. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

SYF

Synchrony

$33.97

0.48 (1.43%)

, SLB

Schlumberger

$31.90

-0.06 (-0.19%)

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Earnings
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SYF

Synchrony

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0.48 (1.43%)

SLB

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$31.90

-0.06 (-0.19%)

AXP

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KO

Coca-Cola

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STT

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$59.71

0.57 (0.96%)

CFG

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$35.01

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Kansas City Southern

$135.33

1.04 (0.77%)

GNTX

Gentex

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-0.01 (-0.04%)

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PLSE

Pulse Biosciences

$14.52

0.525 (3.75%)

20:10
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TW

Tradeweb Markets

$43.20

0.87 (2.06%)

19:50
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Syndicate
Tradeweb Markets 17.29M share Secondary priced at $42.00 »

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SWDAF

Software AG

$0.00

(0.00%)

19:33
10/17/19
10/17
19:33
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19:33
Upgrade
Software AG rating change  »

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PBR

Petrobras

$14.43

-0.22 (-1.50%)

18:57
10/17/19
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18:57
Hot Stocks
Petrobras reports Q3 production 2.878M boepd, up 9.3% »

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  • 25

    Oct

MRTN

Marten Transport

$21.52

0.31 (1.46%)

, ISRG

Intuitive Surgical

$529.22

-1.25 (-0.24%)

18:49
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Fly Intel: After Hours Movers »

UP AFTER EARNINGS: …

MRTN

Marten Transport

$21.52

0.31 (1.46%)

ISRG

Intuitive Surgical

$529.22

-1.25 (-0.24%)

ETFC

E-Trade

$39.04

0.02 (0.05%)

WAL

Western Alliance

$46.24

0.53 (1.16%)

TEAM

Atlassian

$122.43

-1.91 (-1.54%)

PRTK

Paratek Pharmaceuticals

$3.46

0.05 (1.47%)

GIL

Gildan Activewear

$35.38

0.095 (0.27%)

BDN

Brandywine Realty

$14.68

0.13 (0.89%)

EXPO

Exponent

$70.82

1.34 (1.93%)

WDFC

WD-40

$182.75

2.41 (1.34%)

VICR

Vicor Corporation

$32.78

1.16 (3.67%)

OZK

Bank OZK

$28.32

0.03 (0.11%)

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ARWR

Arrowhead

$36.61

2.11 (6.12%)

, AMGN

Amgen

$203.60

0.32 (0.16%)

18:43
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Arrowhead CEO: We can silence a single gene »

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ARWR

Arrowhead

$36.61

2.11 (6.12%)

AMGN

Amgen

$203.60

0.32 (0.16%)

JNJ

Johnson & Johnson

$136.20

1 (0.74%)

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SXT

Sensient

$66.57

0.4 (0.60%)

18:32
10/17/19
10/17
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Hot Stocks
Sensient raises quarterly dividend 8.3% to 39c per share »

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  • 18

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T

AT&T

$37.82

0.03 (0.08%)

18:31
10/17/19
10/17
18:31
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18:31
Periodicals
HBO Max to stream Studio Ghibli films, Reuters says »

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OMAB

OMA

$52.10

0.47 (0.91%)

18:19
10/17/19
10/17
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Earnings
OMA reports Q3 net income MXN858M vs. MXN725M last year »

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  • 18

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MAR

Marriott

$120.57

-0.55 (-0.45%)

18:13
10/17/19
10/17
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Periodicals
Marriott near deal for Elegant Hotels valued up to GBP1 / shr, Bloomberg says »

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  • 05

    Nov

SPY

SPDR S&P 500 ETF Trust

$299.19

0.78 (0.26%)

, SPX

S&P 500

$0.00

(0.00%)

18:08
10/17/19
10/17
18:08
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General news
NY Fed's Williams Condition in money markets highly volatile over past month »

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SPY

SPDR S&P 500 ETF Trust

$299.19

0.78 (0.26%)

SPX

S&P 500

$0.00

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GM

General Motors

$36.20

-0.45 (-1.23%)

17:47
10/17/19
10/17
17:47
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17:47
Periodicals
GM strike to continue until deal with UAW is ratified, WSJ says »

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  • 29

    Oct

T

AT&T

$37.82

0.03 (0.08%)

17:37
10/17/19
10/17
17:37
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17:37
Periodicals
AT&T, Elliott Management in talks to resolve activist campaign, WSJ reports »

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WAL

Western Alliance

$46.24

0.53 (1.16%)

17:27
10/17/19
10/17
17:27
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Earnings
Western Alliance reports Q3 EPS $1.24, consensus $1.19 »

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RNLSY

Renault

$0.00

(0.00%)

17:25
10/17/19
10/17
17:25
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17:25
Downgrade
Renault rating change at Deutsche Bank »

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LOVE

Lovesac

$19.10

0.63 (3.41%)

17:24
10/17/19
10/17
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Hot Stocks
Park West Management reports 5.1% passive stake in Lovesac »

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  • 17

    Dec

T

AT&T

$37.82

0.03 (0.08%)

17:24
10/17/19
10/17
17:24
10/17/19
17:24
Periodicals
Breaking Periodicals news story on AT&T »

AT&T in discussions…

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    Nov

ATVI

Activision Blizzard

$55.60

0.01 (0.02%)

17:16
10/17/19
10/17
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17:16
Hot Stocks
Activision says Call of Duty to get 'battle pass' feature, 'not loot box system' »

Activision's Call of…

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BDN

Brandywine Realty

$14.68

0.13 (0.89%)

17:11
10/17/19
10/17
17:11
10/17/19
17:11
Hot Stocks
Brandywine Realty sees FY19 year-end core occupancy at 94%-95% »

Also sees FY20 year-end…

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  • 18

    Oct

BDN

Brandywine Realty

$14.68

0.13 (0.89%)

17:10
10/17/19
10/17
17:10
10/17/19
17:10
Hot Stocks
Brandywine Realty reports Q3 same-store net operating income up 0.6% »

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  • 18

    Oct

BDN

Brandywine Realty

$14.68

0.13 (0.89%)

17:09
10/17/19
10/17
17:09
10/17/19
17:09
Earnings
Brandywine Realty sees FY20 initial FFO $1.41-$1.51, consensus $1.46 »

Sees FY20 same-store net…

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  • 18

    Oct

GIL

Gildan Activewear

$35.38

0.095 (0.27%)

17:08
10/17/19
10/17
17:08
10/17/19
17:08
Earnings
Gildan Activewear cuts FY19 adj. EPS view to $1.65-$1.70 from $1.95-$2.00 »

Consensus $1.97. Cuts…

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BDN

Brandywine Realty

$14.68

0.13 (0.89%)

17:07
10/17/19
10/17
17:07
10/17/19
17:07
Earnings
Brandywine Realty narrows FY19 FFO guidance to $1.41-$1.43 from $1.40-$1.44 

Consensus $1.42.

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  • 18

    Oct

BDN

Brandywine Realty

$14.68

0.13 (0.89%)

17:07
10/17/19
10/17
17:07
10/17/19
17:07
Earnings
Brandywine Realty reports Q3 FFO 36c, consensus 36c »

Reports Q3 revenue…

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  • 18

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