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MKGAY

Merck KGaA

$0.00

(0.00%)

10:29
06/03/19
06/03
10:29
06/03/19
10:29

Merck KGaA says tepotinib shows 'durable anti-tumor clinical activity'

Merck KGaA presented updated results from the potentially registrational Phase II Visoin study, showing "durable anti-tumor clinical activity" for the investigational targeted therapy tepotinib across different lines of treatment in advanced non-small cell lung cancer patients harboring MET exon 14 skipping mutations detected by liquid biopsy or tissue biopsy. "Tepotinib has been designed to potentially improve outcomes in aggressive tumors that have a poor prognosis and harbor these specific alterations," said Luciano Rossetti, Global Head of Research & Development for the Biopharma business of Merck KGaA, Darmstadt, Germany. "Tepotinib is an important part of our strategic focus on precision medicine, and both the proportion of patients responding and the duration of anti-tumor clinical activity demonstrate the potential of this investigational therapy." Results from the ongoing Phase II Vision study in 73 efficacy-evaluable patients with NSCLC with MET exon 14 skipping mutations identified by LBx or TBx demonstrate overall objective response rate of 50.0% for LBx-identified patients as assessed by Independent Review Committee, and 55.3% as assessed by investigators. The ORR for TBx-identified patients was 45.1% and 54.9%, respectively. The overall median duration of response was 12.4 months and 17.1 months among LBx-identified patients, as assessed by IRC and investigators, respectively, while among TBx-identified patients, 15.7 and 14.3 months were observed, respectively. Most treatment-related adverse events were Grade 1 and 2, Merck KGaA said in a statement.

MKGAY Merck KGaA
$0.00

(0.00%)

03/15/19
UBSW
03/15/19
DOWNGRADE
UBSW
Neutral
Merck KGaA downgraded to Neutral from Buy at UBS
UBS analyst Michael Leuchten downgraded Merck KGaA to Neutral from Buy saying the stock's valuation is now close to his sum-of-the parts analysis. The analyst believes near-term catalysts are now priced into the shares. He lowered his price target for Merck KGaA to EUR 108 from EUR 115.
04/03/19
04/03/19
UPGRADE
Target $56

Buy
Versum Materials upgraded to Buy at Loop Capital on deal prospects
As previously reported, Loop Capital analyst Chris Kapsch upgraded Versum Materials (VSM) to Buy from Hold and raised his price target for the shares to $56 from $53. The analyst say he "really likes" the potential combination with Entegris (ENTG) if it is successful in acquiring the company, as the merged entity would "create a premier mid-cap specialty materials company". Kapsch also speculates that Merck KGaA (MKGAY) is likely to increase its offer to acquire Versum even as the latter's board has "unequivocally spurned" the all-cash $48/share takeout bid and believes the revised proposal could come before the April 26th shareholder vote on the proposed merger of equals with Entegris.
04/08/19
STFL
04/08/19
DOWNGRADE
Target $53
STFL
Hold
Versum Materials downgraded to Hold from Buy at Stifel
Stifel analyst Patrick Ho downgraded Versum Materials (VSM) to Hold from Buy after the company received a revised all-cash offer of $53 per share offer from Merck KGaA (MKGAY) and Entegris (ENTG) announced in a press release that it would not counter this bid. With Entegris turning down a potential counter and walking away, Ho said he does not believe there will be any additional counter, hostile, or unsolicited bidding. He raised his price target for Versum shares to $53 from $46.
04/16/19
04/16/19
DOWNGRADE
Target $53

Hold
Versum Materials downgraded to Hold from Buy at Loop Capital
As previously reported, Loop Capital analyst Chris Kapsch downgraded Versum Materials (VSM) to Hold and lowered his price target to $53 from $56, saying the bidding process for the company has "run its course" after its board agreed to Merck KGaA's (MKGAY) "sweetened" deal over that of Entegris' (ENTG) merger of equals proposal. The analyst says the stock has limited upside from its current levels and expects the deal to close in the second half of 2019.

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AAVMY

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STT

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GLD

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TECK

Teck Resources

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OVLY

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FTNW

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TNXP

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RLMD

Relmada Therapeutics

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General news
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NWSA

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WAIR

Wesco Aircraft

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0.01 (0.09%)

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FOMX

Foamix

$3.15

-0.09 (-2.78%)

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POAI

Predictive Oncology

$0.44

0.0101 (2.35%)

16:40
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Conference/Events
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BK

BNY Mellon

$45.34

0.975 (2.20%)

16:40
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16:40
Hot Stocks
BNY Mellon SVP Harris sells 50K shares of common stock »

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