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MRTX

Mirati Therapeutics

$88.84

21 (30.96%)

, AMGN

Amgen

$174.20

7.49 (4.49%)

13:49
06/03/19
06/03
13:49
06/03/19
13:49

Mirati Therapeutics jumps after Amgen announces AMG 510 data

Shares of biotech firm Mirati Therapeutics (MRTX) are spiking higher on Monday after large-cap peer Amgen (AMGN) announced the first clinical results from a Phase 1 study evaluating investigational AMG 510, the first KRASG12C inhibitor to reach the clinical stage. In the trial, there were no dose-limiting toxicities at tested dose levels. AMG 510 showed anti-tumor activity when administered as a monotherapy in patients with locally-advanced or metastatic KRASG12C mutant solid tumors, Amgen said in a statement. MIRATI'S CANDIDATE: Mirati Therapeutics is developing a KRAS G12C Inhibitor like Amgen's AMG 510. According to the company, MRTX849 has demonstrated broad-spectrum antitumor activity across a panel of KRAS G12C-positive patient- and cell-derived in vivo tumor models, including complete tumor regression in a subset of these models. MRTX849 is now in the clinic and has the potential to provide a long-awaited targeted therapy option for patients exhibiting a KRAS driver mutation, Mirati said on its website. PRICE ACTION: Shares of Mirati Therapeutics are up 31% to $88.39 in afternoon trading, while Amgen is up almost 5% to $174.41.

MRTX

Mirati Therapeutics

$88.84

21 (30.96%)

AMGN

Amgen

$174.20

7.49 (4.49%)

  • 03

    Jun

  • 04

    Jun

MRTX Mirati Therapeutics
$88.84

21 (30.96%)

03/04/19
CANT
03/04/19
INITIATION
CANT
Neutral
Mirati Therapeutics initiated with a Neutral at Cantor Fitzgerald
03/05/19
CANT
03/05/19
INITIATION
Target $66
CANT
Neutral
Mirati Therapeutics initiated with a Neutral at Cantor Fitzgerald
Cantor Fitzgerald analyst Varun Kumar last night started Mirati Therapeutics with a Neutral rating and $66 price target. Current consensus estimates reflect high expectations around the novel KRASi asset, and do not fully appreciate potential clinical, regulatory and commercial risks associated with the company's lead asset sitravatinib, Kumar tells investors in a research note.
03/25/19
FBCO
03/25/19
INITIATION
Target $85
FBCO
Outperform
Mirati Therapeutics initiated with an Outperform at Credit Suisse
Credit Suisse analyst Michael Morabito started coverage of Mirati Therapeutics with an Outperform rating and $85 price target. The analyst believes Mirati holds "several very promising" assets, such as its MRTX849, a highly specific inhibitor of the G12C-mutated KRAS protein, mutations in which are common in multiple cancers. With only one competing drug in clinical development, the competitive landscape is not substantial, he notes.
04/17/19
JPMS
04/17/19
INITIATION
Target $72
JPMS
Neutral
Mirati Therapeutics initiated with a Neutral at JPMorgan
JPMorgan analyst Anupam Rama started Mirati Therapeutics with a Neutral rating and $72 price target. The value for the company's broader pipeline is already somewhat reflected in the shares at current levels, Rama tells investors in a research note. Further, "value-creating catalysts" are more skewed to the second half of 2019 and beyond, the analyst adds.
AMGN Amgen
$174.20

7.49 (4.49%)

05/22/19
SBSH
05/22/19
UPGRADE
SBSH
Buy
Amgen upgraded to Buy from Neutral at Citi
05/22/19
05/22/19
UPGRADE

Citi assumes coverage of large-cap biotech, upgrades Amgen and Gilead
Citi analyst Mohit Bansal assumed coverage of large-cap biotech stocks, assuming coverage with five Buy ratings -- Amgen (AMGN), Alexion Pharmaceuticals (ALXN), Vertex Pharmaceuticals (VRTX), Gilead Sciences (GILD), and BioMarin Pharmaceutical (BMRN) -- and two Neutral ratings -- Biogen (BIIB) and Regeneron Pharmaceuticals (REGN). Both Amgen and Gilead were upgraded to Buy from Neutral as part of the assumption of coverage. The analyst said he is "more optimistic" on the sector as a whole as he sees many biotechs going "back to basics" by investing in their internal pipelines and filling their pipelines with early stage assets. He suggests looking at large caps again, as many are returning to stability and growth. Bansal does not favor large M&A, suggesting discipline due to "realizing value with big M&As."
05/24/19
OPCO
05/24/19
NO CHANGE
Target $210
OPCO
Outperform
Amgen management comments 'encouraging,' says Oppenheimer
Oppenheimer analyst Jay Olson maintained an Outperform rating and $210 price target on Amgen after meeting with the company, saying he maintains his bullish stance. In a research note to investors, Olson says he is "encouraged" by Amgen's comments on the current status of Enbrel, Repatha potential with the lower list price, Aimovig launch and CGRP market dynamics, the oncology pipeline and capital allocation.
06/03/19
PIPR
06/03/19
NO CHANGE
Target $210
PIPR
Overweight
Piper a buyer of Amgen shares after 'impressive' AMG 510 data
Piper Jaffray analyst Christopher Raymond keeps an Overweight rating on Amgen shares with a $210 price target following a first look at the Phase 1 data for AMG 510 in patients with locally-advanced or metastatic KRAS-G12C mutant solid tumors. Initial data presented in the abstract showed a 50% overall response rate in patients with on-small cell lung cancer, and today, "that impressive 50% ORR was maintained," Raymond tells investors in a research note titled "As Good as it Gets; AMG 510 Indicates Serious Utility in NSCLC & Maybe Even CRC." The analyst says that since the study is just Phase 1, he has not modeled the opportunity. However, given "these impressive results and the multi-billion dollar potential here," Raymond thinks it may make sense to begin to layer this into his model at some point. He's a buyer of Amgen in morning trading. The stock in early trading is up 4% to $173.30.

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COP

ConocoPhillips

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AMZN

Amazon.com

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AKS

AK Steel

$2.45

0.055 (2.30%)

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ArcelorMittal

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NUE

Nucor

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STLD

Steel Dynamics

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TMST

TimkenSteel

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GM

General Motors

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AAVMY

ABN Amro

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Banco Bilbao

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BlackRock

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Goldman Sachs

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Zurich Insurance

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STT

State Street

$63.40

3.69 (6.18%)

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SUN

Sunoco

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0.32 (1.00%)

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TLF

Tandy Leather

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Tandy Leather

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AAPL

Apple

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JPM

JPMorgan

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0.21 (0.17%)

, FB

Facebook

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Facebook

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PYPL

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MA

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V

Visa

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EBAY

eBay

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BKNG

Booking Holdings

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GLD

SPDR Gold Shares

$140.47

-0.13 (-0.09%)

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TECK

Teck Resources

$16.48

0.11 (0.67%)

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OSK

Oshkosh

$77.22

0.46 (0.60%)

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OVLY

Oak Valley Bancorp

$16.40

-0.16 (-0.97%)

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FTNW

FTE Networks

$0.79

-0.0185 (-2.29%)

17:21
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TNXP

Tonix Pharmaceuticals

$0.45

0.0048 (1.07%)

17:12
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RLMD

Relmada Therapeutics

$20.18

1.07 (5.60%)

17:10
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16:55
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16:55
General news
Breaking General news story  »

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NWSA

News Corp.

$13.48

-0.19 (-1.39%)

, NWS

News Corp

$13.79

-0.11 (-0.79%)

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News Corp.

$13.48

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NWS

News Corp

$13.79

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FB

Facebook

$185.96

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NYT

New York Times

$29.76

0.21 (0.71%)

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WAIR

Wesco Aircraft

$11.01

0.01 (0.09%)

16:46
10/18/19
10/18
16:46
10/18/19
16:46
Conference/Events
Wesco Aircraft to host special shareholder meeting »

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FOMX

Foamix

$3.15

-0.09 (-2.78%)

16:41
10/18/19
10/18
16:41
10/18/19
16:41
Hot Stocks
Breaking Hot Stocks news story on Foamix »

Foamix up 7.5% at $3.35…

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