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LLY

Eli Lilly

$118.35

0.86 (0.73%)

13:51
06/09/19
06/09
13:51
06/09/19
13:51

Eli Lilly ultra rapid lispro provides similar A1C reductions compared to Humalog

Two phase 3 studies show that Eli Lilly's ultra rapid lispro provided non-inferior A1C reductions compared to Humalog at 26 weeks in people with type 1 and type 2 diabetes. The data from these treat-to-target studies showed URLi also significantly reduced the rise in blood glucose one hour and two hours after a test meal compared to Humalog. Additional data from the study in people with type 1 diabetes demonstrated URLi significantly improved glucose time in range during the day.3 URLi is an investigational novel mealtime insulin formulation being developed to better manage blood glucose levels. These data and several other studies were presented at the American Diabetes Association's 79th Scientific Sessions. The two phase 3 studies, PRONTO-T1D and PRONTO-T2D, evaluated the safety and efficacy of URLi compared to Humalog in adults with type 1 and type 2 diabetes, respectively. Both studies met the primary endpoint of non-inferior A1C reduction from baseline compared to Humalog at 26 weeks, when the insulins were dosed at mealtime. Further, URLi demonstrated superior reduction in blood glucose spikes at both one hour after a test meal compared to Humalog. The PRONTO studies were designed as treat-to-target, which enables clinicians to determine differences in other important treatment effects - such as rates of hypoglycemia, post-meal glucose control and glucose time in range - at the same level of glycemic control. A sub-set of participants in PRONTO-T1D were evaluated using blinded continuous glucose monitoring to provide more complete information on daily blood glucose patterns. At 26 weeks, URLi demonstrated a significantly better blood glucose profile up to four hours after breakfast compared to Humalog. The study further showed that URLi had significantly longer time in range during the day and similar time in range during the night compared to Humalog. Data from a phase 1 clinical pharmacology study in people with type 1 diabetes also demonstrated URLi's effect on post-meal blood glucose control. Results showed URLi was absorbed significantly faster into the blood stream compared to Humalog, insulin aspart and fast-acting insulin aspart. URLi also showed lower blood glucose spikes after a test meal compared to the insulins tested, which was significant compared to Humalog and insulin aspart. Additionally, the early blood glucose profile with URLi closely matched that of participants without diabetes. Lilly submitted applications for URLi with regulatory authorities in Europe and Japan and plans to submit in the U.S. later this year.

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LLY Eli Lilly
$118.35

0.86 (0.73%)

04/23/19
EDJN
04/23/19
UPGRADE
EDJN
Buy
Eli Lilly upgraded to Buy from Hold at Edward Jones
Edward Jones analyst Ashtyn Evans upgraded Eli Lilly to Buy from Hold.
04/24/19
04/24/19
UPGRADE

Fly Intel: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Eli Lilly (LLY) upgraded to Buy from Hold at Edward Jones. 2. Snap (SNAP) upgraded to In Line from Underperform at Evercore ISI and to Neutral from Underweight at JPMorgan. 3. Best Buy (BBY) upgraded to Buy from Hold at Jefferies with analyst Jonathan Matuszewski saying survey and data work suggest Best Buy's greater push toward services will drive long-term value and customer wallet share. 4. Procter & Gamble (PG) upgraded to Overweight from Equal Weight at Barclays with analyst Lauren Lieberman saying the market is shrugging off Procter & Gamble's 5% organic sales growth in its fiscal Q3, with many investors thinking this is the best it can get. 5. Sonoco (SON) upgraded to Buy from Hold at Argus with analyst David Coleman saying the stock has outperformed over the past 3 months, benefiting from its "accretive acquisitions, favorable pricing, improvements in productivity, and a lower effective tax rate." This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
05/28/19
GSCO
05/28/19
INITIATION
Target $135
GSCO
Buy
Eli Lilly initiated with a Buy at Goldman Sachs
Goldman Sachs analyst Terence Flynn started Eli Lilly with a Buy rating and $135 price target. The company has new product cycles in four large and growing therapeutic categories - diabetes, cancer, pain and immunology, Flynn tells investors in a research note. He believes investors are underappreciating Eli Lilly's longer-term growth potential in diabetes.
05/30/19
WELS
05/30/19
NO CHANGE
WELS
U.S. generic data continues to show challenging environment, says Wells Fargo
Wells Fargo analyst David Maris says that according to April IQVIA data, Teva (TEVA) U.S. generic sales were down 19% in April year over year, while brands sales were down 15%. Additionally, according to IQVIA data, Teva recently ceded its second place U.S. prescription market share place to competitor Eli Lilly (LLY) for its migraine drug, Ajovy, he points out. For Mylan (MYL), Maris says the monthly trends also paint a negative picture, with IQVIA U.S. generic sales in April down 36%. Nonetheless, the analyst believes Teva and Mylan shares seem to be reflecting an "aggressively negative outlook" given the current earnings multiples, and setting aside the worst-case outcomes in the opioid and price fixing cases, these may be at or nearing attractive valuations. However, for now, he remains on the sidelines, and within generics, continues to recommend Outperform-rated Amphastar (AMPH).

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IWM

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CMCSA

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CMCSK

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DIS

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$131.26

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T

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$38.45

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AXP

American Express

$117.55

-1.62 (-1.36%)

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MFGP

Micro Focus

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MFGP

Micro Focus

$14.05

-0.52 (-3.57%)

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OTEX

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MFGP

Micro Focus

$14.06

-0.51 (-3.50%)

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OpenText

$40.37

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MFGP

Micro Focus

$14.06

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HOG

Harley-Davidson

$36.89

0.19 (0.52%)

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FOMX

Foamix

$3.15

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CMCSA

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$45.60

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$45.60

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CMCSK

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T

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VIAB

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VIA

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$24.88

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FDX

FedEx

$149.86

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PUMP

ProPetro Holding

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NLY

Annaly Capital

$8.77

0.1 (1.15%)

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IVZ

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$15.76

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D

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$82.18

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BCS

Barclays

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0.12 (1.43%)

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$NSD

NASDAQ Market Internals

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$NYE

NYSE Market Internals

$0.00

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FANG

Diamondback Energy

$82.71

-1.42 (-1.69%)

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  • 06

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QQQ

Invesco QQQ Trust

$192.00

-1.56 (-0.81%)

, SPY

SPDR S&P 500 ETF Trust

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QQQ

Invesco QQQ Trust

$192.00

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SPY

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$298.50

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IWM

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$152.78

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XLU

Utilities SPDR

$63.76

0.16 (0.25%)

IVV

iShares Core S&P 500

$300.17

-0.76 (-0.25%)

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XEC

Cimarex Energy

$42.31

-0.36 (-0.84%)

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  • 05

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SPXC

SPX Corporation

$40.48

0.265 (0.66%)

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WE

We Company

$0.00

(0.00%)

, JPM

JPMorgan

$120.80

0.41 (0.34%)

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WE

We Company

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JPM

JPMorgan

$120.80

0.41 (0.34%)

SFTBF

SoftBank

$0.00

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JNJ

Johnson & Johnson

$129.11

-7.09 (-5.21%)

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