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KPTI

Karyopharm

$5.80

0.05 (0.87%)

12:22
06/14/19
06/14
12:22
06/14/19
12:22

Karyopharm EHA Phase 1b/2 combination data 'encouraging,' says H.C. Wainwright

H.C. Wainwright analyst Edward White maintained a Buy rating and $29 price target on Karyopharm, saying the company presented "encouraging" early Phase 1b/2 selinexor combination data from the STOMP trial in relapsed or refractory multiple myeloma patients at the European Hematological Association 2019 Annual Meeting. In a research note to investors, White says the updated selinexor with Darzalex data "continues to look good," with efficacy results showing an overall response rate of 73% in Darzalex naive patients versus the EHA abstract data published last month with an ORR of 77%. Looking ahead, White projects revenues of $189M and $241M for selinexor in penta-refractory multiple myeloma and DLBCL, respectively, in 2026. For selinexor in combination multiple myeloma treatment, he forecasts revenues of $332M in 2026, and for selinexor in solid tumors he sees revenues of $241M in 2026.

  • 06

    Jul

KPTI Karyopharm
$5.80

0.05 (0.87%)

02/27/19
WEDB
02/27/19
NO CHANGE
Target $6
WEDB
Outperform
Karyopharm price target lowered to $6 from $14 at Wedbush
Wedbush analyst David Nierengarten lowered his price target for Karyopharm to $6 from $14 following the outcome of the FDA Advisory Committee Meeting regarding the potential approval of selinexor in penta-refractory multiple myeloma by the PDUFA date of April 6, 2019. The analyst notes that the panel voted 8 yes to 5 no to the question of "Should the approval of selinexor be delayed until results of the randomized phase 3 trial, BOSTON, are available?," as key concerns around safety, dose reductions and study design previously introduced in the published briefing docs prevailed, although the vote also indicated a receptiveness, particularly among treating physicians, for a novel drug like selinexor that could help serve this highly refractory patient population with limited treatment options. Nierengarten reiterates an Outperform rating on the shares.
02/28/19
HCWC
02/28/19
NO CHANGE
Target $30
HCWC
Buy
H.C. Wainwright says selinexor expectations not changed by ODAC recommendation
After the FDA's Oncologic Drugs Advisory Committee, or ODAC, voted on February 26 to recommend that the FDA wait for the Phase 3 BOSTON trial results before deciding on selinexor's NDA application, H.C. Wainwright analyst Edward White noted that the decision was not unanimous and said "the FDA typically but does not always follow the ODAC panel's recommendations." It is possible that a delay to wait for the BOSTON data could push out a selinexor launch by one year or more, but the ODAC recommendation is "not changing our expectations," stated White, who keeps a Buy rating and $30 price target on shares of Karyopharm.
03/01/19
JPMS
03/01/19
DOWNGRADE
Target $7
JPMS
Neutral
Karyopharm downgraded to Neutral from Overweight at JPMorgan
JPMorgan analyst Eric Joseph downgraded Karyopharm Therapeutics to Neutral and lowered his price target for the shares to $7 from $21. The analyst sees a "rocky regulatory road" forward for the company.
03/15/19
WEDB
03/15/19
NO CHANGE
WEDB
Wedbush views Karyopharm 's PDUFA date extension as a positive
Wedbush analyst David Nierengarten maintained an Outperform rating and $6 price target on Karyopharm. In a note titled "FDA Extends PDUFA by Three Months," he said he is inclined to view the extension as a positive for the company "given the negative sentiment on the name and general belief that an April 6, 2019 approval was unlikely."

TODAY'S FREE FLY STORIES

LEN

Lennar

$50.94

-0.47 (-0.91%)

11:33
06/25/19
06/25
11:33
06/25/19
11:33
Earnings
Lennar sees Q3 EPS $1.25-$1.35, consensus $1.52 »

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11:30
06/25/19
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11:30
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11:30
General news
Treasury announced a $75 B batch of auctions for Thursday »

Treasury announced a $75…

ACER

Acer Therapeutics

$4.31

-14.86 (-77.52%)

11:25
06/25/19
06/25
11:25
06/25/19
11:25
Downgrade
Acer Therapeutics rating change  »

Acer Therapeutics…

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  • 25

    Jun

CLDR

Cloudera

$5.53

0.005 (0.09%)

11:25
06/25/19
06/25
11:25
06/25/19
11:25
Options
Cloudera call volume above normal and directionally bullish »

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CODI

Compass Diversified

$19.00

0.345 (1.85%)

11:25
06/25/19
06/25
11:25
06/25/19
11:25
Conference/Events
Compass Diversified to host investor & analyst meeting »

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  • 25

    Jun

UMC

UMC

$2.14

-0.01 (-0.47%)

11:23
06/25/19
06/25
11:23
06/25/19
11:23
Upgrade
UMC rating change  »

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  • 24

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ACER

Acer Therapeutics

$4.30

-14.87 (-77.57%)

11:18
06/25/19
06/25
11:18
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11:18
Downgrade
Acer Therapeutics rating change  »

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  • 25

    Jun

IBKR

Interactive Brokers

$52.52

0.07 (0.13%)

, ETFC

E-Trade

$44.03

-0.54 (-1.21%)

11:17
06/25/19
06/25
11:17
06/25/19
11:17
Conference/Events
Sandler O'Neill financial analyst to hold an analyst/industry conference call »

Financial Analyst Repetto…

IBKR

Interactive Brokers

$52.52

0.07 (0.13%)

ETFC

E-Trade

$44.03

-0.54 (-1.21%)

SCHW

Charles Schwab

$39.09

-0.06 (-0.15%)

AMTD

TD Ameritrade

$47.90

-0.19 (-0.40%)

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    Oct

$NSD

NASDAQ Market Internals

$0.00

(0.00%)

11:17
06/25/19
06/25
11:17
06/25/19
11:17
Technical Analysis
NASDAQ market internals summary »

Volume is average for…

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$NYE

NYSE Market Internals

$0.00

(0.00%)

11:16
06/25/19
06/25
11:16
06/25/19
11:16
Technical Analysis
NYSE market internals summary »

Volume is average for…

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DLTR

Dollar Tree

$110.51

-2.21 (-1.96%)

11:15
06/25/19
06/25
11:15
06/25/19
11:15
Options
Dollar Tree put volume heavy and directionally bearish »

Bearish flow noted in…

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PBR

Petrobras

$16.24

-0.34 (-2.05%)

11:05
06/25/19
06/25
11:05
06/25/19
11:05
Options
Petrobras call volume above normal and directionally bullish »

Bullish option flow…

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  • 26

    Jun

RDS.B

Royal Dutch Shell

$66.83

0.04 (0.06%)

11:02
06/25/19
06/25
11:02
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11:02
Conference/Events
Royal Dutch Shell management to meet with JPMorgan »

Meetings to be held in…

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  • 25

    Jun

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    Jun

MSADY

MS&AD Insurance

$0.00

(0.00%)

11:00
06/25/19
06/25
11:00
06/25/19
11:00
Conference/Events
MS&AD Insurance management to meet with JPMorgan »

Meetings to be held in…

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  • 25

    Jun

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    Jun

DNKN

Dunkin' Brands

$79.51

-1.5 (-1.85%)

, GRUB

GrubHub

$75.00

2.95 (4.09%)

11:00
06/25/19
06/25
11:00
06/25/19
11:00
On The Fly
Grubhub upgrade, Brighthouse downgrades among today's top analyst actions »

Check out today's top…

DNKN

Dunkin' Brands

$79.51

-1.5 (-1.85%)

GRUB

GrubHub

$75.00

2.95 (4.09%)

BHF

Brighthouse Financial

$34.28

-3.82 (-10.03%)

MSFT

Microsoft

$135.30

-2.5 (-1.81%)

AMZN

Amazon.com

$1,887.85

-25.58 (-1.34%)

SHAK

Shake Shack

$67.38

0.7 (1.05%)

CMG

Chipotle

$735.05

10.91 (1.51%)

SBUX

Starbucks

$84.19

0.54 (0.65%)

MCD

McDonald's

$204.99

1.07 (0.52%)

YUM

Yum! Brands

$110.44

-0.18 (-0.16%)

WEN

Wendy's

$19.21

0.06 (0.31%)

JACK

Jack in the Box

$81.61

-1.22 (-1.47%)

TIF

Tiffany

$90.50

-1.36 (-1.48%)

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  • 06

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  • 08

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  • 14

    Aug

  • 14

    Aug

  • 13

    Nov

11:00
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11:00
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General news
The U.S. consumer confidence drop to a 2-year low »

The U.S. consumer…

HR

Healthcare Realty Trust

$32.43

0.23 (0.71%)

10:59
06/25/19
06/25
10:59
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10:59
Conference/Events
Healthcare Realty Trust management to meet with JPMorgan »

Meetings to be held in…

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  • 25

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UN

Unilever; also tag UL

$61.77

-0.11 (-0.18%)

, UL

Unilever; also tag UN

$62.81

-0.11 (-0.17%)

10:59
06/25/19
06/25
10:59
06/25/19
10:59
Periodicals
Unilever to close Nevada plant, impacting about 300 jobs, Reuters reports »

Unilever plans to close…

UN

Unilever; also tag UL

$61.77

-0.11 (-0.18%)

UL

Unilever; also tag UN

$62.81

-0.11 (-0.17%)

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BCKIF

Babcock

$0.00

(0.00%)

10:57
06/25/19
06/25
10:57
06/25/19
10:57
Conference/Events
Babcock management to meet with JPMorgan »

Meetings to be held in…

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  • 25

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ALKS

Alkermes

$21.78

0.19 (0.88%)

10:55
06/25/19
06/25
10:55
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10:55
Conference/Events
Alkermes management to meet with JPMorgan »

Meetings to be held in…

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  • 25

    Jun

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HRL

Hormel Foods

$41.11

-1.04 (-2.47%)

10:55
06/25/19
06/25
10:55
06/25/19
10:55
Options
Hormel Foods put volume heavy and directionally bearish »

Bearish flow noted in…

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10:55
06/25/19
06/25
10:55
06/25/19
10:55
General news
Treasury 2-year auction outlook: today's auction will be a test »

Treasury 2-year auction…

EEFT

Euronet

$161.01

-1.51 (-0.93%)

10:55
06/25/19
06/25
10:55
06/25/19
10:55
Conference/Events
Euronet management to meet with William Blair »

Group Luncheon Meeting to…

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  • 25

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    Nov

UBER

Uber

$43.35

0.35 (0.81%)

10:52
06/25/19
06/25
10:52
06/25/19
10:52
Initiation
Uber initiated at Daiwa »

Uber initiated with a…

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  • 09

    Jul

10:45
06/25/19
06/25
10:45
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10:45
General news
Breaking General news story  »

8-Week Bill Announcement…

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