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EDIT

Editas Medicine

$21.72

-0.78 (-3.47%)

13:30
06/16/19
06/16
13:30
06/16/19
13:30

Editas presents pre-clinical data in Sickle Cell Disease, Beta-Thalassemia

Editas Medicine announced results from a follow-up study to assess two different CRISPR genome editing strategies, one targeting the BCL11A erythroid enhancer and one targeting the beta-globin locus, for the treatment of sickle cell disease and beta-thalassemia. In this study, NBSGW mice received an infusion of human CD34+ cells which had been edited either at the BCL11Ae or at the beta-globin locus. In vivo-derived erythroid cells from BCL11Ae-edited CD34+ hematopoietic stem/progenitor cells had reduced total indels and increased non-productive indels as compared to other tested lineages, a phenomenon not observed with beta-globin locus editing. Additionally, further optimization of nuclease and guide RNA combinations led to fetal hemoglobin expression of approximately 40 percent in the beta-globin locus-edited erythroid cells. Based on the data, Editas Medicine has initiated IND-enabling activities for EDIT-301, an experimental CRISPR medicine designed to durably treat sickle cell disease and beta-thalassemia by editing the beta-globin locus.

EDIT Editas Medicine
$21.72

-0.78 (-3.47%)

10/09/18
GUGG
10/09/18
INITIATION
GUGG
Neutral
Editas Medicine initiated with a Neutral at Guggenheim
Guggenheim analyst Whitney Ijem initiated Editas Medicine with a Neutral rating, calling the company's potential "mostly theoretical at this point as the company has yet to identify programs where these assets can be uniquely deployed."
02/07/19
BTIG
02/07/19
INITIATION
BTIG
Buy
Editas Medicine initiated with a Buy at BTIG
BTIG analyst Amanda Murphy initiated Editas Medicine with a Buy rating and $30 price target. Murphy sees Editas having the broadest CRISPR toolbox, noting that "with its IP portfolio, Editas can target ten times as many sites in the genome relative to wild-type spCas9 and roughly 95% of the human genome in total."
04/11/19
EVER
04/11/19
INITIATION
Target $34
EVER
Outperform
Editas Medicine initiated with an Outperform at Evercore ISI
Evercore ISI analyst Ravi Mehrotra initiated Editas Medicine (EDIT) with an Outperform rating and a price targets of $34. The analyst cites the company's "strong clinical positioning of lead program EDIT-101", saying that if its efficacy is demonstrated in LCA-10 and proven durable, it will likely have "significant uptake over Sepofarsen, which requires chronic dosing." Mehrotra adds that Editas Medicine's partnership with Allergan (AGN) "adds reinforcement".
04/22/19
BTIG
04/22/19
NO CHANGE
BTIG
Buy
BTIG raises price targets on Editas Medicine, CRISPR Therapeutics
BTIG analyst Amanda Murphy raised her price target on Buy-rated Editas Medicine (EDIT) to $33 from $30 and CRISPR Therapeutics (CRSP) to $49 from $43 as part of her first installment of a broader research note analyzing hiring trends in the gene therapy space. The analyst notes that the latter is "aggressively adding process development/CMC/Tech capabilities in cell therapy, including late stage process development resources", which may suggest that the company is "farther along" in the development of CTX110. Murphy also observes that Editas Medicine appears to be "shifting focus to engineered stem cell therapy while still investing in allo CAR-T and potentially new in vivo indications and delivery vectors."

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