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AMGN

Amgen

$176.09

-0.74 (-0.42%)

13:40
06/16/19
06/16
13:40
06/16/19
13:40

Amgen announces BLINCYTO five-year overall survival data

Amgen announced the five-year overall survival analysis from the single-arm, Phase 2 BLAST study that evaluated BLINCYTO in patients with minimal residual disease-positive acute lymphoblastic leukemia. The study found that with a median follow-up of 59.8 months, the median OS for BLINCYTO-treated patients was 36.5 months. More than half of patients who achieved a complete MRD response following the first cycle of BLINCYTO treatment were alive at five years. These results from the largest prospective trial ever conducted in MRD-positive ALL were presented during an oral presentation at the 24th Annual Congress of the European Hematology Association in Amsterdam. The Phase 2 open-label BLAST study enrolled 116 patients with MRD-positive Philadelphia chromosome-negative B-cell precursor ALL in first or subsequent complete hematologic remission after at least three intensive chemotherapy blocks of treatment. Of the 116 enrolled patients, OS was evaluated for 110 patients with less than five percent leukemic blasts, including 74 patients who received hematopoietic stem cell transplantation in continuous complete remission after BLINCYTO treatment. Results presented at EHA showed that in 84 patients who achieved a complete MRD response, median OS was not reached compared to 14.4 months for those who had measurable MRD. Among patients with MRD in first complete remission, median OS was not reached for those who achieved a complete MRD response versus 10.6 months for those who did not achieve complete MRD response. Safety results among MRD-positive patients were consistent with the known safety profile of BLINCYTO.

  • 16

    Sep

AMGN Amgen
$176.09

-0.74 (-0.42%)

06/04/19
RHCO
06/04/19
NO CHANGE
Target $120
RHCO
Buy
Mirati Therapeutics price target raised to $120 from $85 at SunTrust
SunTrust analyst Peter Lawson raised his price target on Mirati Therapeutics (MRTX) to $120 and kept his Buy rating following yesterday's "encouraging" ASCO presentation by Amgen (AMGN) regarding its KRAS G12C inhibitor AMG 510. The analyst notes that the side effect profile and response to the treatment's lowest dose in AMG 510 are positive for Mirati's MRTX849, raising his probability Adjusted Peak Sales for the latter to $1.65B from $1.33B with probability of success little changed at 52%.
06/05/19
LEHM
06/05/19
NO CHANGE
Target $123
LEHM
Overweight
Mirati Therapeutics price target raised to $123 from $85 at Barclays
Barclays analyst Gena Wang raised her price target for Mirati Therapeutics (MRTX) to $123 from $85 saying Amgen's (AMGN) AMG510 data support KRAS G12C as a validated target, and the "impressive" data provide proof of concept for potentially single agent activity in non-small cell lung cancer. The analyst continues to believe that Mirati's MRTX849 could have a more favorable profile based on the preclinical results, including "longer half-life and good tissue penetration." She reiterates an Overweight rating on Mirati Therapeutics.
06/05/19
HCWC
06/05/19
NO CHANGE
Target $117
HCWC
Buy
Mirati Therapeutics price target raised to $117 from $84 at H.C. Wainwright
H.C. Wainwright analyst Edward White raised his price target for Mirati Therapeutics (MRTX) to $117 from $84 saying the positive data for Amgen's (AMGN) AMG 510 bode well for Mirati's MRTX849. The analyst believes the AMG 510 data "somewhat derisks" the development of MRTX849/ He raised his estimate for probability of success for MRTX849 to 20% from 10% and keeps a Buy rating on Mirati Therapeutics.
06/07/19
GUGG
06/07/19
DOWNGRADE
GUGG
Neutral
Guggenheim downgrades Mirati to Neutral following near-tripling of stock
As previously reported, Guggenheim analyst Michael Schmidt downgraded Mirati Therapeutics (MRTX) to Neutral from Buy, noting that the shares have nearly tripled since data were presented at the European Society for Medical Oncology, or ESMO, meeting in October. While Schmidt said Amgen's (AMGN) KRAS inhibitor Phase I data presented at the American Society of Clinical Oncology meeting validates MRTX849's potential mechanism of action, he sees a "lot of upside" priced in at the current valuation despite the remaining development risks. He also believes investor expectations have significantly increased ahead of Mirati's own Phase I data presentation in the second half of the year.

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CMG

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BYND

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NFLX

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  • 03

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AMZN

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, TGT

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AMZN

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AMZN

Amazon.com

$1,964.78

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, MSFT

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SNY

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BHVN

Biohaven Pharmaceutical

$44.16

-0.61 (-1.36%)

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  • 09

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CE

Celanese

$107.01

0.9 (0.85%)

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F

Ford

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RTN

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$178.55

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  • 25

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UTX

United Technologies

$132.37

1.08 (0.82%)

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  • 23

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LMT

Lockheed Martin

$356.90

0.675 (0.19%)

17:40
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  • 23

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ARES

Ares Management

$28.13

-0.305 (-1.07%)

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HAFC

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  • 23

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PAYS

Paysign

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MEOH

Methanex

$43.19

0.83 (1.96%)

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  • 01

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Conference/Events
Credit Suisse biotech analysts to hold an analyst/industry conference call »

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SHIP

Seanergy Marine

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SONM

Sonim

$13.42

0.24 (1.82%)

16:41
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KINS

Kingstone Companies

$8.81

0.09 (1.03%)

16:30
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Kingstone names Barry Goldstein CEO »

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  • 07

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16:30
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Options
Preliminary option volume of 22.6M today »

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BA

Boeing

$377.34

16.17 (4.48%)

, MSFT

Microsoft

$136.62

0.33 (0.24%)

16:24
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On The Fly
Fly Intel: Wall Street's top stories for Friday »

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BA

Boeing

$377.34

16.17 (4.48%)

MSFT

Microsoft

$136.62

0.33 (0.24%)

AMZN

Amazon.com

$1,964.78

-13.57 (-0.69%)

AAPL

Apple

$202.62

-3.02 (-1.47%)

WMT

Walmart

$113.91

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DIS

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$139.86

-1.76 (-1.24%)

GCI

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$9.43

1.53 (19.37%)

CRWD

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$83.50

10.75 (14.78%)

SKX

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$39.00

4.25 (12.23%)

PACB

Pacific Biosciences

$5.34

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ILMN

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$293.10

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CHWY

Chewy

$30.70

-2.09 (-6.37%)

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