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SEEL

Seelos Therapeutics

$2.25

0.04 (1.81%)

07:11
06/27/19
06/27
07:11
06/27/19
07:11

Seelos Therapeutics acquires license for gene therapy program

Seelos Therapeutics announced the exclusive worldwide licensing of a gene therapy program targeting the regulation of the SNCA gene, which encodes alpha-synuclein expression, from Duke University. Seelos plans to study this approach, named SLS-004, initially in Parkinson's Disease. At present, there is no effective treatment to prevent PD or halt its progression. The SNCA gene has been implicated as a highly significant risk factor for PD. In addition, accumulating evidence suggests that elevated levels of wild-type alpha-synuclein are causative in the pathogenesis of PD. The role of SNCA overexpression in PD pathogenesis and the need to maintain normal physiological levels of alpha-synuclein protein emphasize the so-far unmet need to develop new therapeutic strategies, such as SLS-004, targeting the regulatory mechanisms of SNCA expression. SLS-004 is an all-in-one lentiviral vector, for targeted DNA-methylation editing within intron. The system is based on CRISPR-dCas9 fused with the catalytic domain of DNA methyltransferase 3A (DNMT3A), an enzyme that is responsible for DNA methylation. The system was delivered to dopaminergic neurons derived from human induced pluripotent stem cells from a PD patient. As a result, the expression of SNCA was modified and disease-related cellular-phenotypes characteristics of the neurons were reversed.

SEEL Seelos Therapeutics
$2.25

0.04 (1.81%)

05/14/19
ROTH
05/14/19
INITIATION
Target $8
ROTH
Buy
Seelos Therapeutics initiated with a Buy at Roth Capital
Roth Capital analyst Yasmeen Rahimi started coverage of Seelos Therapeutics with a Buy rating and $8 price target. The analyst says the company has an "enriched" pipeline, with numerous milestones in 2019 and top-line results from PK/PD of SLS-002 to treat acute suicidality in early 2020.
05/10/19
HCWC
05/10/19
INITIATION
Target $4
HCWC
Buy
Seelos Therapeutics initiated with a Buy at H.C. Wainwright
H.C. Wainwright started Seelos Therapeutics with a Buy rating and $4 price target.

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