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WVE

Wave Life Sciences

$25.81

-0.08 (-0.31%)

08:13
06/27/19
06/27
08:13
06/27/19
08:13

Wave Life Sciences initiates DYSTANCE 51 trial of suvodirsen

Wave Life Sciences announced the initiation of DYSTANCE 51, the Phase 2/3 efficacy and safety clinical trial of suvodirsen, an investigational stereopure oligonucleotide intended for boys with Duchenne muscular dystrophy who are amenable to exon 51 skipping. DYSTANCE 51 is a global study and is expected to include clinical trial sites in the United States, Europe, Australia, Canada and Japan. Results from this trial are intended to support global regulatory filings for suvodirsen.

WVE Wave Life Sciences
$25.81

-0.08 (-0.31%)

05/20/19
RHCO
05/20/19
NO CHANGE
Target $39
RHCO
Buy
Wave Life Sciences price target lowered to $39 from $60 at SunTrust
SunTrust analyst Edward Nash lowered his price target on Wave Life Sciences to $39 to reflect its "turbulent" April. The analyst cites the company's top-line data from the ongoing Phase I/II PRECISION-HD program being pushed back to 2019-end from first-half end and its suvodirsen study in Duchenne Muscular Dystrophy raising concerns about its safety and tolerability. Longer term, Nash keeps his Buy rating on Wave Life Sciences however, saying he continues to see value in its platform technology and forecasting the upcoming data from its DMD and HD programs in the second half of the year to "mark turning points for the stock."
04/18/19
MZHO
04/18/19
NO CHANGE
Target $65
MZHO
Buy
Mizuho defends Wave Life Sciences, says suvodirsen not drisapersen
Mizuho analyst Salim Syed yesterday afternoon came out "defending" shares of Wave Life Sciences (WVE) following the recent selloff. The reaction has been based on false logic, primarily equating Wave Life's suvodirsen to BioMarin's (BMRN) failed drisapersen, Syed told investors in a research note. Suvodirsen "is NOT" drisapersen and the lower suvodirsen Phase 2/3 dosing versus drisapersen's "does not necessarily imply a lesser or even similar dystrophin expression," Syed wrote. Further, the Phase 2/3 dosing "was selected rationally, seems within the therapeutic window, and is likely favorable to current standard of care," he contends. The analyst adds that the Phase 1 safety data "was still generally clean." Syed keeps a Buy rating on Wave Life Sciences with a $65 price target.
04/17/19
HCWC
04/17/19
NO CHANGE
Target $33
HCWC
Buy
Wave Life Sciences price target lowered to $33 from $49 at H.C. Wainwright
H.C. Wainwright analyst Debjit Chattopadhyay lowered his price target for Wave Life Sciences to $33 from $49 following the first look at the company's stereopure isomer platform with a preliminary read on safety and dose for the planned Phase 2/3 program from patients amenable to exon 51 skipping. The analyst believes Wave has a "lot to prove" with limited near-term catalysts. Nonetheless, he keeps a Buy rating on the stock.
04/16/19
04/16/19
DOWNGRADE

Hold
Wave Life Sciences downgraded to Hold from Buy at Stifel
As previously reported, Stifel analyst Paul Matteis downgraded Wave Life Sciences to Hold from Buy, and reduced his target price on shares to $26 from $53. The analyst believes the company's Duchenne muscular dystrophy, or DMD, update from this morning "raises concerns around suvodirsen and more broadly, the degree to which leveraging stereochemistry will lead to a differentiated ASO-based medicines." While Matteis still sees Huntington's disease as a potential source of upside for the stock, the "recent delay -- especially in light of the DMD update this morning -- has reduced [the analyst's] level of conviction in Wave management's execution and the bull-case on its platform/technology."

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