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KPTI

Karyopharm

$8.90

2.37 (36.29%)

08:03
07/05/19
07/05
08:03
07/05/19
08:03

Wedbush boosts Karyopharm target to $11 from $6 on Xpovio approval

Wedbush analyst David Nierengarten raised his price target for Karyopharm Therapeutics to $11 from $6 after the FDA on Wednesday approved selinexor, now branded as Xpovio, in combination with dexamethasone for the treatment of multiple myeloma in patients who have received at least four prior therapies. The stock closed Wednesday up 36% to $8.90. The label has no black box warnings or contraindications, but does include extensive safety monitoring guidelines and recommendations, Nierengarten tells investors in a research note. Karyopharm has priced Xpovio at $22,000 per month, which comes in higher than expected but is "not unreasonable" in comparison to other FDA-approved multiple myeloma drugs, contends the analyst. He projects sales of $9.1M in fiscal 2019, with peak sales potential approaching $300M. Nierengarten keeps an Outperform rating on Karyopharm Therapeutics.

  • 06

    Jul

KPTI Karyopharm
$8.90

2.37 (36.29%)

03/01/19
JPMS
03/01/19
DOWNGRADE
Target $7
JPMS
Neutral
Karyopharm downgraded to Neutral from Overweight at JPMorgan
JPMorgan analyst Eric Joseph downgraded Karyopharm Therapeutics to Neutral and lowered his price target for the shares to $7 from $21. The analyst sees a "rocky regulatory road" forward for the company.
03/15/19
WEDB
03/15/19
NO CHANGE
WEDB
Wedbush views Karyopharm 's PDUFA date extension as a positive
Wedbush analyst David Nierengarten maintained an Outperform rating and $6 price target on Karyopharm. In a note titled "FDA Extends PDUFA by Three Months," he said he is inclined to view the extension as a positive for the company "given the negative sentiment on the name and general belief that an April 6, 2019 approval was unlikely."
06/14/19
HCWC
06/14/19
NO CHANGE
Target $29
HCWC
Buy
Karyopharm EHA Phase 1b/2 combination data 'encouraging,' says H.C. Wainwright
H.C. Wainwright analyst Edward White maintained a Buy rating and $29 price target on Karyopharm, saying the company presented "encouraging" early Phase 1b/2 selinexor combination data from the STOMP trial in relapsed or refractory multiple myeloma patients at the European Hematological Association 2019 Annual Meeting. In a research note to investors, White says the updated selinexor with Darzalex data "continues to look good," with efficacy results showing an overall response rate of 73% in Darzalex naive patients versus the EHA abstract data published last month with an ORR of 77%. Looking ahead, White projects revenues of $189M and $241M for selinexor in penta-refractory multiple myeloma and DLBCL, respectively, in 2026. For selinexor in combination multiple myeloma treatment, he forecasts revenues of $332M in 2026, and for selinexor in solid tumors he sees revenues of $241M in 2026.
07/05/19
HCWC
07/05/19
NO CHANGE
Target $32
HCWC
Buy
Karyopharm approval label for Xpovio 'compelling,' says H.C. Wainwright
Karyopharm Therapeutics on Wednesday, three days before the action date date, announced that the FDA granted accelerated approval for Xpovio n relapsed or refractory multiple myeloma patients who have received at least four prior therapies and whose disease was refractory after at least two proteasome inhibitors, at least two immunomodulatory agents, and an anti-CD38 monoclonal antibody, H.C. Wainwright analyst Edward White tells investors in a research note. Further, there is not a black box warning or contraindications in the Xpovio label, adds the analyst. He finds the label "compelling and inline with expectations." White estimates Xpovio in the penta-refractory setting will have sales of $5.5less than this year rising to $123.8M in 2026. He keeps a Buy rating on Karyopharm Therapeutics with a $32 price target.

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