ChromaDex: Safety and efficacy of Niagen validated in recent study
ChromaDex announced that the results of its latest clinical study were published Friday in the journal Scientific Reports. The largest trial of nicotinamide riboside published to date, the new study further validates the safety and efficacy of ChromaDex's proprietary form of NR, Niagen. "The results of this large human trial directly support the efficacy and safety of our NAD-boosting consumer product Tru Niagen," says ChromaDex CEO Rob Fried. "The study also provides key data points for regulatory submissions as we continue our global expansion." This is the first clinical trial to measure both the kinetics and dose-dependent effects of chronic Niagen supplementation. 132 healthy overweight adults completed the randomized, double-blind, placebo-controlled, parallel arm trial. The results show how supplementation with three different daily doses of Niagen (100 mg, 300 mg, 1000 mg) initially increase and then sustain elevated blood NAD levels over the course of an 8-week period. The results of this study directly support the NAD-boosting efficacy of Tru Niagen, which recommends a daily serving size of 300 mg in the United States. On average, study participants consuming 300 mg/day experienced a statistically significant 51% increase in whole blood NAD+ within two weeks. This increase was maintained throughout the remainder of the eight-week study. The study also joins previous chronic supplementation studies to support the safety of chronic Niagen supplementation. All doses tested were well-tolerated with no attributable adverse events reported. By the end of the eight-week trial, no changes in LDL cholesterol levels or blood levels of homocysteine were observed. These results further differentiate Niagen from other NAD-boosting supplements and support the establishment of a unique upper limit for Niagen versus other B3 vitamins.