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BMRN

BioMarin

$81.00

-1.02 (-1.24%)

, SGMO

Sangamo

$12.64

1.24 (10.88%)

11:17
07/08/19
07/08
11:17
07/08/19
11:17

BioMarin's Valrox maintains competitive advantage, says Piper Jaffray

After BioMarin (BMRN) announced that the company will submit regulatory filings for Valrox to both the FDA and EMA in Q4, and after the company and competitive partners Sangamo (SGMO) and Pfizer (PFE) both presented updates at this weekend's International Society on Thrombosis and Hemostasis meeting, Piper Jaffray analyst Christopher Raymond said that he still believes the company's roughly 2-year head start puts Valrox at a competitive advantage. Following the confirmation on timing for accelerated filing, Raymond said he would continue to be a buyer of BioMarin shares and he keeps an Overweight rating on the stock.

BMRN

BioMarin

$81.00

-1.02 (-1.24%)

SGMO

Sangamo

$12.64

1.24 (10.88%)

PFE

Pfizer

$43.20

-0.7 (-1.59%)

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BMRN BioMarin
$81.00

-1.02 (-1.24%)

06/18/19
JPMS
06/18/19
NO CHANGE
Target $133
JPMS
Overweight
BioMarin remains 'high conviction long-term idea' at JPMorgan
After hosting a call with the company's CEO Jean-Jacques Bienaime and Head of R&D Hank Fuchs, JPMorgan analyst Cory Kasimov says BioMarin remains a "high conviction long-term idea." The analyst highlights the company's orphan-focused, "diversified" base business, "growing" commercial portfolio, and "potentially disruptive" late-stage pipeline. The analyst notes that BioMarin management does not believe the company is are getting enough credit for its pipeline opportunities and that investor concerns around competitive risks are overblown. Kasimov reiterates an Overweight rating on BioMarin shares with a $133 price target.
05/28/19
COWN
05/28/19
NO CHANGE
Target $150
COWN
Outperform
BioMarin shares undervalued, valrox 'appears viable,' says Cowen
Cowen analyst Phil Nadeau continues to view shares of BioMarin Pharmaceutical as undervalued following this morning's data update. He keeps an Outperform rating on the name with a $150 price target. The Phase I/II data suggest sufficient durability and the interim Phase III should support an FDA filing, Nadeau tells investors in a research note. As such, the analyst believes valrox "appears viable."
05/28/19
FBCO
05/28/19
NO CHANGE
Target $133
FBCO
BioMarin data alleviates valrox durability overhang, re-awakens M&A, says Credit Suisse
Credit Suisse raised its price target for BioMarin (BMRN) to $133 from $131, while nudging up valrox Probability of Success to 75% from 65%. The firm thinks the valoctocogene roxaparvovec data largely alleviates the valrox durability overhang and re-awakens an M&A thesis on BioMarin on the value of its gene therapy platform. The company's de-risked Phase 3 valrox program and established mfg infrastructure put the company's gene tx assets in the valuation range up to that established by the AveXis (AVXS) and Spark Therapeutics (ONCE) transactions, Credit Suisse contends.
06/10/19
CANT
06/10/19
NO CHANGE
Target $131
CANT
Overweight
BioMarin hemophilia A potential larger than anticipated, says Cantor Fitzgerald
Cantor Fitzgerald analyst Eliana Merle says her survey of 25 hemophilia A prescribers suggests the market opportunity for BioMarin's valrox program is larger than appreciated. Current share levels assume valrox is roughly a ~$500M peak opportunity, Merle tells investors in a research note, citing her math. However, the penetration rates expected by the physicians in the survey suggest a "much-larger" peak opportunity of $1.5B-plus, adds the analyst, citing her estimates. She thinks the survey results suggest there may be a "meaningful disconnect" in investor and physician perspectives on valrox. Merle keeps an Overweight rating on BioMarin with a $131 price target.
SGMO Sangamo
$12.64

1.24 (10.88%)

02/07/19
WELS
02/07/19
NO CHANGE
Target $24
WELS
Outperform
Wells Fargo says buy Sangamo on today's 'overdone' selloff
Wells Fargo analyst Jim Birchenough lowered his price target for Sangamo Therapeutics to $24 from $39 following today's update for in-vivo gene editing in mucopolysaccharidosis type I and II. While overall results are disappointing in terms of markers of sustainable efficacy and suggest further optimization required of gene editing efficiency and delivery, individual patient validation with significant iduronate-2-sulfatase enzyme production in one of two high dose MPSII patients and evidence of enzyme production in MPSI is encouraging, Birchenough tells investors in an intraday research note titled "Over Reaction To In-Vivo Gene Editing Update." The analyst believes Sangamo shares are "oversold" on today's news and recommends buying on the weakness. He maintains an Outperform rating on the name. Sangamo shares in in afternoon trading are down 36%, or $4.28, to $7.74.
02/08/19
JEFF
02/08/19
NO CHANGE
Target $23
JEFF
Buy
Jefferies sees opportunity in Sangamo after selloff, drops target to $23
Jefferies analyst Maury Raycroft says his Buy thesis on Sangamo Therapeutics is unchanged following yesterday's update. The analyst lowered his price target for the shares to $23 from $26 and maintains a Buy rating. Sangamo demonstrated successful in vivo editing, Raycroft tells investors in a research note. The analyst has confidence in the company's update, noting Sangamo was able to detect an albumin-IDS mRNA transcript in a liver biopsy aspirate that extracted around 100,000-300,000 cells for analysis. Further, concern about patient six and the transaminitis is likely an overreaction as liver enzyme elevation is consistent across gene therapy programs, adds the analyst. Raycroft sees opportunity in Sangamo shares following yesterday's selloff.
02/08/19
GSCO
02/08/19
NO CHANGE
Target $21
GSCO
Buy
Goldman says Orchard track record stands out amid disappointments in gene space
Goldman Sachs analyst Graig Suvannavejh noted that February 7 was "a day of disappointment" in the gene therapy and gene editing space, as Solid Biosciences (SLDB) and Sangamo (SGMO) both reported clinical efficacy data that missed investor expectations and "perhaps also raised concerns about the long-term promise of gene-based approaches." Within this context, he pointed out that he believes Orchard Therapeutics (ORTX) has "the most robust clinical experience in gene therapy, with over 150 patients treated across multiple product candidates and indications." The analyst, who expects new clinical data for Orchard candidates OTL-101 and OTL-102 to be presented later this month to re-affirm his confidence, reiterated his Buy rating and $21 price target on Orchard shares.
04/02/19
WELS
04/02/19
NO CHANGE
Target $34
WELS
Outperform
Sangamo price target raised to $34 from $24 at Wells Fargo
Wells Fargo analyst Jim Birchenough raised his price target for Sangamo Therapeutics to $34 from $24 following this morning's clinical update on the company's gene therapy, gene editing and cell therapy pipeline. The stock in morning trading is up 35%, or $3.35, to $12.88. The update was better than expected, particularly for hemophilia gene therapy and beta thalassemia ex vivo gene editing, Birchenough tells investors in a research note. The analyst is "encouraged" by Sangamo's progress against the higher technical hurdle of in vivo genome editing. He believes direct evidence of genome editing, "strong" fetal hemoglobin response and early signs of transfusion independence bode well for ultimate success and should translate into improved likelihood of success in the larger opportunity of sickle cell disease. The analyst reiterates an Outperform rating on Sangamo Therapeutics.
PFE Pfizer
$43.20

-0.7 (-1.59%)

06/28/19
PIPR
06/28/19
NO CHANGE
Target $208
PIPR
Overweight
'Almost impossible' for Pfizer to compete with Sarepta, says Piper Jaffray
Sarepta Therapeutics (SRPT) went from the front-runner to "basically a standalone" in the Duchenne muscular dystrophy gene therapy race after this morning's data from Pfizer (PFE) showed "serious safety signals" that led to hospitalization in two of six patients dosed, Piper Jaffray analyst Danielle Brill tells investors in a research note. And while Pfizer believes complement activation was driven by a high presence of neutralizing antibodies, the serious adverse event was also observed with Solid Biosciences' (SLDB) gene therapy, which employs the same vector as Pfizer, adds the analyst. As a result, Brill thinks complement activation may be AAV9 related, especially since no such signal has been seen with Sarepta's AAVrh74 vector. In addition, Pfizer has no edge over Sarepta on efficacy either, says the analyst. She thinks it will be "almost impossible" for Pfizer to compete moving forward and reiterates an Overweight rating on Sarepta with a $208 price target. The stock in afternoon trading is up 16%, or $20.61, to $150.37.
06/28/19
WBLR
06/28/19
NO CHANGE
WBLR
Outperform
Sarepta has clear lead in DMD after Pfizer disappoints, says William Blair
William Blair analyst Tim Lugo calls Sarepta Therapeutics (SRPT) the "clear leader" in Duchenne muscular dystrophy without a close number two after this morning's results from Pfizer (PFE) disappointed. Shares of Sarepta are up 15%, or $20.04, to $149.80 in midday trading.
06/28/19
JPMS
06/28/19
NO CHANGE
JPMS
Overweight
Sarepta 'still in pole position' in DMD after Pfizer data, says JPMorgan
JPMorgan analyst Anupam Rama said that Sarepta (SRPT) is "still in the pole position" in Duchenne muscular dystrophy, or DMD, after Pfizer (PFE) presented preliminary data from its own ongoing Phase 1b study of DMD gene therapy PF-06939926. Rama has an Overweight rating on Sarepta shares.
07/08/19
CANT
07/08/19
DOWNGRADE
Target $48
CANT
Neutral
Array BioPharma downgraded to Neutral from Overweight at Cantor Fitzgerald
Cantor Fitzgerald analyst Varun Kumar downgraded Array BioPharma (ARRY) to Neutral from Overweight while raising his price target for the shares to $48 from $34. The analyst cites the pending takeover by Pfizer (PFE) for the downgrade.

TODAY'S FREE FLY STORIES

BYND

Beyond Meat

$176.65

6.28 (3.69%)

07:40
07/20/19
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07:40
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Beyond Meat could spike after earnings, Barron's says »

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NFLX

Netflix

$315.10

-10.04 (-3.09%)

07:37
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AMZN

Amazon.com

$1,964.78

-13.57 (-0.69%)

, TGT

Target

$88.02

-0.48 (-0.54%)

07:34
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07/20
07:34
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Periodicals
Time to aim higher on Target's stock, Barron's says »

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Amazon.com

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AMZN

Amazon.com

$1,964.78

-13.57 (-0.69%)

, FDX

FedEx

$167.08

1.69 (1.02%)

07:31
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07/20
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07:31
Periodicals
FedEx ups game amid e-commerce growth, Barron's says »

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AMZN

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FDX

FedEx

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1.69 (1.02%)

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AMZN

Amazon.com

$1,964.78

-13.57 (-0.69%)

, MSFT

Microsoft

$136.62

0.33 (0.24%)

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AMZN

Amazon.com

$1,964.78

-13.57 (-0.69%)

MSFT

Microsoft

$136.62

0.33 (0.24%)

ORCL

Oracle

$57.55

-0.58 (-1.00%)

AZN

AstraZeneca

$40.11

-0.61 (-1.50%)

BMY

Bristol-Myers

$43.32

-0.72 (-1.63%)

LLY

Eli Lilly

$106.75

-1.57 (-1.45%)

GSK

GlaxoSmithKline

$40.97

-0.44 (-1.06%)

JNJ

Johnson & Johnson

$130.41

-1.62 (-1.23%)

MRK

Merck

$81.39

-1.28 (-1.55%)

NVS

Novartis

$93.58

-0.715 (-0.76%)

PFE

Pfizer

$42.78

-0.28 (-0.65%)

RHHBY

Roche

$0.00

(0.00%)

SNY

Sanofi

$41.94

-0.01 (-0.02%)

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    Nov

BHVN

Biohaven Pharmaceutical

$44.16

-0.61 (-1.36%)

18:12
07/19/19
07/19
18:12
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18:12
Hot Stocks
Biohaven receives CRL from FDA for application seeking NURTEC approval »

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CE

Celanese

$107.01

0.9 (0.85%)

18:01
07/19/19
07/19
18:01
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18:01
Hot Stocks
Celanese announces acetyl intermediates price increases »

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  • 23

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F

Ford

$10.20

-0.06 (-0.58%)

17:48
07/19/19
07/19
17:48
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17:48
Periodicals
Ford plans to lay off 185 employees at Ontario plant, Reuters reports »

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RTN

Raytheon

$178.55

2.45 (1.39%)

17:48
07/19/19
07/19
17:48
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17:48
Hot Stocks
Raytheon awarded $191.01M Air Force contract modification »

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  • 25

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UTX

United Technologies

$132.37

1.08 (0.82%)

17:44
07/19/19
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17:44
Hot Stocks
United Technologies awarded $253.71M Air Force contract »

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  • 23

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LMT

Lockheed Martin

$356.90

0.675 (0.19%)

17:40
07/19/19
07/19
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Lockheed Martin awarded $1.47B Missile Defense Agency contract modification »

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  • 23

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ARES

Ares Management

$28.13

-0.305 (-1.07%)

17:33
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Syndicate
Breaking Syndicate news story on Ares Management »

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HAFC

Hanmi Financial

$21.68

-0.105 (-0.48%)

17:33
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Hanmi Financial to delay release of Q2 results »

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  • 23

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PAYS

Paysign

$17.49

-0.48 (-2.67%)

17:32
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07/19
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17:32
Syndicate
Breaking Syndicate news story on Paysign »

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MEOH

Methanex

$43.19

0.83 (1.96%)

17:28
07/19/19
07/19
17:28
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17:28
Hot Stocks
Methanex reaches final investment decision on methanol plant in Geismar, LA »

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  • 01

    Aug

17:17
07/19/19
07/19
17:17
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17:17
Conference/Events
Credit Suisse biotech analysts to hold an analyst/industry conference call »

Biotech Analysts provide…

17:14
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UBS retail/hardlines analyst to hold an analyst/industry conference call »

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SHIP

Seanergy Marine

$0.64

-0.0425 (-6.25%)

17:05
07/19/19
07/19
17:05
07/19/19
17:05
Hot Stocks
Seanergy Maritime receives noncompliance notice from Nasdaq »

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SONM

Sonim

$13.42

0.24 (1.82%)

16:41
07/19/19
07/19
16:41
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16:41
Conference/Events
Sonim management to meet with Oppenheimer »

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KINS

Kingstone Companies

$8.81

0.09 (1.03%)

16:30
07/19/19
07/19
16:30
07/19/19
16:30
Hot Stocks
Kingstone names Barry Goldstein CEO »

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  • 07

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    Aug

16:30
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16:30
Options
Preliminary option volume of 22.6M today »

Preliminary option volume…

BA

Boeing

$377.34

16.17 (4.48%)

, MSFT

Microsoft

$136.62

0.33 (0.24%)

16:24
07/19/19
07/19
16:24
07/19/19
16:24
On The Fly
Fly Intel: Wall Street's top stories for Friday »

Stocks were tentatively…

BA

Boeing

$377.34

16.17 (4.48%)

MSFT

Microsoft

$136.62

0.33 (0.24%)

AMZN

Amazon.com

$1,964.78

-13.57 (-0.69%)

AAPL

Apple

$202.62

-3.02 (-1.47%)

WMT

Walmart

$113.91

-0.77 (-0.67%)

DIS

Disney

$139.86

-1.76 (-1.24%)

GCI

Gannett

$9.43

1.53 (19.37%)

CRWD

Crowdstrike

$83.50

10.75 (14.78%)

SKX

Skechers

$39.00

4.25 (12.23%)

PACB

Pacific Biosciences

$5.34

-0.53 (-9.03%)

ILMN

Illumina

$293.10

-5.44 (-1.82%)

CHWY

Chewy

$30.70

-2.09 (-6.37%)

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VIX

Volatility Index S&P 500 Options

$0.00

(0.00%)

16:20
07/19/19
07/19
16:20
07/19/19
16:20
Options
Closing CBOE SPX and VIX Index summary for July 19th »

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$NSD

NASDAQ Market Internals

$0.00

(0.00%)

16:17
07/19/19
07/19
16:17
07/19/19
16:17
Technical Analysis
NASDAQ market internals summary »

Volume was average for…

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BCBP

BCB Bancorp

$12.71

-0.09 (-0.70%)

16:17
07/19/19
07/19
16:17
07/19/19
16:17
Earnings
BCB Bancorp reports Q2 EPS 30c, consensus 30c »

Net interest margin was…

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