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XBIT

XBiotech

$7.73

-0.03 (-0.39%)

08:11
07/09/19
07/09
08:11
07/09/19
08:11

XBiotech announces funding from MRC for Phase 2 study of bermekimab

XBiotech announced that the Medical Research Council, part of UK Research and Innovation, has awarded funding to study bermekimab therapy in a Phase 2 multi-center study in advanced cancers. The MRC will provide funding for all clinical costs of the Phase 2 study to treat patients with advanced lung, pancreatic and ovarian cancers. The phase 2 study will be conducted at multiple cancer centers across the UK. Patients will receive eight weekly doses of bermekimab and be assessed for tumor-related wasting and other quality of life symptoms, The study was developed in conjunction with the National Institute for Health Research Cancer & Nutrition Collaboration and the National Cancer Research Institute Supportive and Palliative Care Group. Bermekimab targets the inflammatory cytokine interleukin-1a and has been used in other innovative oncology studies. The Company previously met its primary endpoint in a randomized double-blind, placebo-controlled study with bermekimab for the treatment of advanced colorectal cancer. The primary endpoint in the study was a novel symptom cluster, which assessed a combination of physical symptoms-pain, fatigue, anorexia and muscle wasting-that are key measures of patient quality of life and predictors of survival. Patients treated with bermekimab were significantly more likely to achieve the primary endpoint compared to placebo; moreover, patients who achieved the primary endpoint had one-fifth as many serious adverse events, were twice as likely to have stable disease, showed significant and clinically relevant improvement in all life quality measures, and had almost three-fold increase in survival compared to failures.

XBIT XBiotech
$7.73

-0.03 (-0.39%)

06/14/19
PIPR
06/14/19
INITIATION
Target $13
PIPR
Overweight
XBiotech initiated with an Overweight at Piper Jaffray
Piper Jaffray analyst Joseph Catanzaro started XBiotech with an Overweight rating and $13 price target. Clinical activity for the company's lead asset bermekimab in two inflammatory skin diseases - hidradenitis suppurativa and atopic dermatitis - has been "very encouraging," Catanzaro tells investors in a research note. He believes these early data compare favorably to standard of care biologics Humira and Dupixent in each setting, respectively. The analyst expects XBiotech shares to appreciate as it advances bermekimab in both indications.

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SWDBY

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EFC

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EPRT

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FTSV

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EBAY

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NFLX

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MIRM

Mirum Pharmaceuticals

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GSBC

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NFLX

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NFLX

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NFLX

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NFLX

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IBM

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