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ACIU

AC Immune

$5.47

-0.01 (-0.18%)

08:24
07/11/19
07/11
08:24
07/11/19
08:24

AC Immune reports initial interim data from Phase 1b trial of ACI-24 vaccine

AC Immune announced initial interim data from an ongoing Phase 1b trial of the ACI-24 anti-Abeta vaccine to treat Alzheimer's disease like symptoms in subjects with Down syndrome as well as key takeaways from its Key Opinion Leader meeting, held in New York City. The event is being co-chaired by Professor Pfeifer and Professor William Mobley, Executive Director of the University of California San Diego's Down Syndrome Center for Research and Treatment. It features presentations from Professor Mobley and Dr. Brian Skotko, Associate Professor at Harvard Medical School and the Emma Campbell Endowed Chair on Down Syndrome and Director of the Down Syndrome Program at Massachusetts General Hospital, as well as Professor Pfeifer and Dr. Marie Kosco-Vilbois, Chief Scientific Officer of AC Immune. Highlights from Dr. Kosco-Vilbois' presentation include: The trial is a fully enrolled, placebo-controlled, 16 subjects Phase 1b study of AC Immune's ACI-24 anti-Abeta vaccine; To date, ACI-24 was well tolerated by DS subjects, demonstrating a favorable safety profile at all doses tested, mirroring previous clinical trial results; There were no subjects withdrawals from the study or serious adverse events reported, no signals of CNS inflammation or other pro-inflammatory reactions, no amyloid-related imaging abnormalities or indication of meningoencephalitis; Preliminary immunogenicity data showed an anti-Abeta IgG response that was detectable at week 4; Pending the final outcome, the Phase 2 study of ACI-24 in subjects with DS would likely focus on disease prevention and will include biomarkers and Positron Emission Tomography; imaging to monitor disease progression, in addition to quantifying anti-Abeta IgG titers generated by the vaccine.

  • 11

    Jul

ACIU AC Immune
$5.47

-0.01 (-0.18%)

11/13/18
LEER
11/13/18
INITIATION
Target $18
LEER
Outperform
AC Immune initiated with an Outperform at Leerink
Leerink analyst Marc Goodman started AC Immune with an Outperform and $18 price target as he initiates Neuroscience space with a Positive View. The analyst believes the Neuroscience sector is experiencing a "renaissance" as multiple new agents and mechanisms are coming up the pipeline across major therapeutic areas, the number of clinical studies is growing nicely, and the FDA is friendly to innovation in this space, companies are getting smarter about speed-to-market strategies and selecting niche sub-populations to focus on for initial product approvals, payer pushback on usage is much lower than in other categories, and physicians are enthusiastic about new agents. Regarding AC Immune, Goodman notes that it has a diversified pipeline of drug candidates and diagnostics for Alzheimer's disease led by a late stage antibody with crenezumab, and has strong partners with Roche (RHHBY) for crenezumab, Johnson & Johnson (JNJ) for Anti-Tau vaccine, Biogen (BIIB) for alphasynuclein-PET tracer diagnostic, and Piramal for TauPET tracer diagnostic.
01/04/19
UBSW
01/04/19
INITIATION
Target $16
UBSW
Buy
AC Immune initiated with a Buy at UBS
UBS analyst Carter Gould initiated AC Immune with a Buy rating and $16 price target.
02/01/19
UBSW
02/01/19
DOWNGRADE
Target $4
UBSW
Neutral
AC Immune downgraded to Neutral from Buy at UBS
UBS analyst Carter Gould downgraded AC Immune to Neutral and cut his price target for the shares to $4 from $6. The analyst says "life after crenezumab is a waiting game until tau."
02/04/19
HCWC
02/04/19
NO CHANGE
Target $8
HCWC
Buy
AC Immune price target lowered to $8 from $18 at H.C. Wainwright
H.C. Wainwright analyst Andrew Fein lowered his price target for AC Immune to $8 to reflect the discontinuation of crenezumab in the valuation. However, despite this setback, the analyst still believes that the fundamental approach of AC Immune is "de-risking in itself" with multiple targets in multiple modalities. The company possesses one of the deepest pipelines in the neurodegenerative space, Fein tells investors in a research note. He reiterates a Buy rating on the shares.

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MAN

ManpowerGroup

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POST

Post Holdings

$108.09

0.64 (0.60%)

20:12
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Upgrade
Post Holdings rating change at Piper Jaffray »

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VMW

VMware

$174.34

0.13 (0.07%)

19:01
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VMware to acquire Bitfusion, terms not disclosed »

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CRWD

Crowdstrike

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Skechers

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0.35 (1.02%)

18:50
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Fly Intel: After Hours Movers »

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Crowdstrike

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Skechers

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Exponent

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MSFT

Microsoft

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Chewy

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Red Robin

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Gannett

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IFRX

InflaRx

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BA

Boeing

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MVIS

MicroVision

$0.86

0.0458 (5.62%)

OZK

Bank OZK

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ISRG

Intuitive Surgical

$536.44

13.25 (2.53%)

AA

Alcoa

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MGM

MGM Resorts

$28.75

-0.095 (-0.33%)

, MGP

MGM Growth

$30.00

-0.06 (-0.20%)

18:50
07/18/19
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Periodicals
MGM said to consider sale-leaseback of Bellagio, MGM Grand, Bloomberg says »

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MGM

MGM Resorts

$28.75

-0.095 (-0.33%)

MGP

MGM Growth

$30.00

-0.06 (-0.20%)

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AAL

American Airlines

$33.75

0.5 (1.50%)

, UAL

United Continental

$95.27

0.44 (0.46%)

18:49
07/18/19
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Periodicals
POTUS meets with U.S. airlines over Qatar subsidy accusations, Reuters says »

U.S. President Donald…

AAL

American Airlines

$33.75

0.5 (1.50%)

UAL

United Continental

$95.27

0.44 (0.46%)

JBLU

JetBlue

$19.23

0.14 (0.73%)

FDX

FedEx

$165.39

0.375 (0.23%)

AAWW

Atlas Air

$42.58

0.79 (1.89%)

BA

Boeing

$361.17

-8.28 (-2.24%)

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NUE

Nucor

$54.68

-0.03 (-0.05%)

18:44
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Hot Stocks
Nucor CEO: We are very pleased with the results from the tariffs »

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NABZY

National Australia Bank

$0.00

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18:30
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National Australia Bank names Ross McEwan as new CEO »

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BAC

Bank of America

$29.48

0.3 (1.03%)

18:22
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Bank of America CEO: Millennials are a huge customer base for us »

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TAP

Molson Coors

$54.37

0.08 (0.15%)

18:06
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Hot Stocks
Molson Coors raises quarterly dividend to 57c from 41c per share »

Molson Coors declared a…

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  • 31

    Jul

MSFT

Microsoft

$136.29

0.06 (0.04%)

18:04
07/18/19
07/18
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18:04
Hot Stocks
Breaking Hot Stocks news story on Microsoft »

Microsoft up over 2%…

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BAS

Basic Energy

$1.81

-0.1 (-5.24%)

18:02
07/18/19
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18:02
Hot Stocks
Basic Energy announces record setting lateral completion in Permian Basin »

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MSFT

Microsoft

$136.29

0.06 (0.04%)

18:02
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Hot Stocks
Microsoft CFO continues to expect double digit revenue growth in FY20 »

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QTRH

Quarterhill

$1.23

(0.00%)

18:02
07/18/19
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WiLAN unit acquires patent portfolio from Vidiator »

Wi-LAN announced that…

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MSFT

Microsoft

$136.29

0.06 (0.04%)

18:00
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Earnings
Microsoft sees total Q1 revenue at implied $31.7B-$32.4B, consensus $32.0B »

By segment: Sees Q1…

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RRGB

Red Robin

$30.58

0.32 (1.06%)

18:00
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Hot Stocks
Red Robin up 17% after confirming $40.00 per share offer from Vintage Capital »

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T

AT&T

$33.09

-0.17 (-0.51%)

17:54
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Periodicals
AT&T mulls sale of Puerto Rican business to pay down debt, Bloomberg says »

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RRGB

Red Robin

$30.58

0.32 (1.06%)

17:53
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Hot Stocks
Red Robin confirms $40.00 per share cash buyout proposal from Vintage Capital »

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MSFT

Microsoft

$136.29

0.06 (0.04%)

17:50
07/18/19
07/18
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17:50
Hot Stocks
Microsoft CFO: Q4 another quarter of double-digit top and bottom line growth »

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HBIO

Harvard Bioscience

$1.78

0.03 (1.71%)

17:46
07/18/19
07/18
17:46
07/18/19
17:46
Hot Stocks
Harvard Bioscience names Michael Rossi CFO »

Harvard Bioscience has…

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MSFT

Microsoft

$136.29

0.06 (0.04%)

17:43
07/18/19
07/18
17:43
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17:43
Hot Stocks
Microsoft CEO seeing growing momentum across every layer of its stack »

Says LinkedIn saw record…

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ISRG

Intuitive Surgical

$536.44

13.25 (2.53%)

17:38
07/18/19
07/18
17:38
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17:38
Hot Stocks
Intuitive Surgical falls after Q2 report, despite earnings beat »

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GLD

SPDR Gold Shares

$136.44

1.85 (1.37%)

17:33
07/18/19
07/18
17:33
07/18/19
17:33
Hot Stocks
SPDR Gold Shares holdings rise to 814.62MT from 803.18MT »

This is the highest level…

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