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VNDA

Vanda Pharmaceuticals

$13.45

-0.13 (-0.96%)

16:18
07/16/19
07/16
16:18
07/16/19
16:18

Vanda Pharmaceuticals announces study results for tradipitant

Vanda Pharmaceuticals announced that tradipitant, a neurokinin-1 receptor antagonist, was effective in treating motion sickness in a clinical study conducted in the Pacific Ocean. The clinical efficacy results are from the Motion Sifnos Phase II clinical study. In this study, 126 people with a prior history of motion sickness were subjected to sea travel in the Pacific Ocean. Study participants were randomized to receive either tradipitant or placebo in a blinded fashion. The study had two primary endpoints: percentage of participants vomiting, and Motion Sickness Severity Scale, or MSSS, Worst score. In the overall population, a significantly higher percentage of participants experienced vomiting in the placebo arm as compared to the tradipitant arm, 39.7% versus 17.5% respectively. The MSSS Worst score endpoint also favored tradipitant, but the difference did not reach statistical significance, 3.75 versus 3.4. Vanda intends to initiate a Phase III program in Motion Sickness, with a plan to file for marketing authorization in 2020.

  • 16

    Aug

VNDA Vanda Pharmaceuticals
$13.45

-0.13 (-0.96%)

02/06/19
CANT
02/06/19
DOWNGRADE
Target $30
CANT
Neutral
Cantor downgrades Vanda on reduced visibility after FDA complaint
Cantor Fitzgerald analyst Charles Duncan downgraded Vanda Pharmaceuticals to Neutral from Overweight and lowered his price target for the shares to $30 from $38. The company's complaint against the FDA reduces visibility on development timelines for tradipitant in gastroparesis, perhaps even pruritus, and may also affect Hetlioz label expansion efforts, Duncan tells investors in a research note. The "challenged" FDA interactions are a result of management disagreement with the agency over the scientific merits of conducting certain nonclinical testing, says the analyst.
02/06/19
02/06/19
DOWNGRADE

Fly Intel: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. PayPal (PYPL) downgraded to Neutral from Buy at Guggenheim with the firm citing balanced risk/reward. 2. Arlo Technologies (ARLO) downgraded to Underperform from Neutral at BofA/Merrill and to Market Perform from Outperform at Cowen. 3. Celanese (CE) downgraded to Market Perform from Outperform at Cowen with analyst Charles Neivert saying recent subtle changes in industry fundamentals and the macro outlook have made him more cautious. 4. Estee Lauder (EL) downgraded to Hold from Buy at Berenberg with analyst Rosie Edwards saying that while the company's Q2 results were "strong across the board," she expects top-line growth to moderate, due mainly to skincare and Asia-Pacific. 5. Vanda Pharmaceuticals (VNDA) downgraded to Neutral from Overweight at Cantor Fitzgerald with analyst Charles Duncan saying the company's complaint against the FDA reduces visibility on development timelines for tradipitant in gastroparesis, perhaps even pruritus, and may also affect Hetlioz label expansion efforts. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
02/14/19
OPCO
02/14/19
NO CHANGE
Target $21
OPCO
Perform
Vanda Pharmaceuticals price target lowered to $21 from $29 at Oppenheimer
Oppenheimer analyst Esther Rajavelu lowered her price target for Vanda Pharmaceuticals to $21 from $29 after the company reported Q4 results that were higher than her estimates and provided 2019 guidance which came in below her estimates. While the analyst acknowledges management's comments that scripts for sighted N24 patients continue to grow robustly, Rajavelu is somewhat concerned by continued payor pushback on coverage for this patient pool despite Vanda Pharmaceuticals' efforts to increase access. She remains constructive on the potential for Hetlioz use in SMS patients and reiterates a Perform rating on the shares.
05/02/19
SBSH
05/02/19
DOWNGRADE
SBSH
Neutral
Vanda Pharmaceuticals downgraded to Neutral from Buy at Citi

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$NSD

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$0.00

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$NYE

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SHAK

Shake Shack

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-1.17 (-1.21%)

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10:13
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General news
E-Commerce Retail Sales E- Q/Q Change SAAR data reported »

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NXPI

NXP Semiconductors

$103.80

0.25 (0.24%)

, AMD

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$31.81

0.63 (2.02%)

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OXY

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APD

Air Products

$228.62

-0.15 (-0.07%)

, WLL

Whiting Petroleum

$8.65

0.04 (0.46%)

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Fly Intel: Top five analyst downgrades »

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APD

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$228.62

-0.15 (-0.07%)

WLL

Whiting Petroleum

$8.65

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CELG

Celgene

$95.15

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AMGN

Amgen

$204.27

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ARLP

Alliance Resource Partners

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Trillium Therapeutics

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DECK

Deckers Brands

$138.02

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LYFT

Lyft

$52.22

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$1,197.73

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SE

Sea Limited

$36.60

1.17 (3.30%)

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Sea Limited call volume above normal and directionally bullish »

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  • 20

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BMA

Banco Macro

$35.45

-2.83 (-7.39%)

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JNUG

Direxion Daily Jr Gld Mnrs Bull 3X Shrs

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UNT

Unit Corp.

$3.58

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  • 13

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BE

Bloom Energy

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ARMK

Aramark

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QSR

Restaurant Brands

$74.89

0.36 (0.48%)

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TGNA

Tegna

$15.70

0.62 (4.11%)

, APO

Apollo Global

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TRCO

Tribune Media

$46.48

(0.00%)

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