Breaking News Instant updates and real-time market news.

NCNA

NuCana

$9.80

-0.05 (-0.51%)

07:02
07/17/19
07/17
07:02
07/17/19
07:02

NuCana doses first patients in Phase I study of NUC-7738

NuCana announced that the first patients have been dosed in the Phase I study of NUC-7738. This is the third ProTide NuCana has advanced to clinical studies and further broadens the therapeutic scope of the ProTide portfolio. NUC-7738 is NuCana's ProTide transformation of 3'-deoxyadenosine, a novel nucleoside analog with a unique mode of action, that has shown potent anti-cancer activity in preclinical studies. NUC-7738 is a ProTide transformation of cordycepin, a nucleoside analog that was isolated from the fungus Cordyceps sinensis in 1950. Cordycepin has demonstrated potent anti-cancer activity in multiple preclinical studies, but has not been successfully developed primarily due to its degradation by the enzyme adenosine deaminase. Unlike the parent nucleoside analogue, NUC-7738 is not a substrate for this enzyme and is therefore resistant to degradation by ADA. Similar to NuCana's other ProTides, NUC-7738 is designed to generate significantly higher levels of the active anti-cancer metabolite of cordycepin, 3'-deoxyadenosine triphosphate P, directly inside cells, bypassing the resistance mechanisms of transport, activation and breakdown.

NCNA NuCana
$9.80

-0.05 (-0.51%)

10/18/18
PIPR
10/18/18
INITIATION
Target $36
PIPR
Overweight
NuCana initiated with an Overweight at Piper Jaffray
Piper Jaffray analyst Joseph Catanzaro started NuCana with an Overweight rating and $36 price target, stating that data for its lead product, Acelarin, have "strongly" pointed towards platform validation. He sees an opportunity for the drug in platinum-resistant ovarian cancer and sees the potential for it to "establish a new frontline standard of care in biliary tract cancer," Catanzaro tells investors.
10/21/18
PIPR
10/21/18
NO CHANGE
Target $36
PIPR
Overweight
NuCana updated Phase Ib data positive for acelarin in biliary cancer, says Piper Jaffray
Piper Jaffray analyst Joseph Catanzaro notes that NuCana presented updated Phase Ib data for Acelarin plus cisplatin in 1st-line advanced BTC at ESMO this weekend. An ORR of 50% in 14 patients is consistent with the abstract and continues to suggest a near doubling of standard of care, he adds, highlighting that tumor reductions appear to be durable out to the 36-week assessment and the safety profile is unremarkable compared to gem/cis. The analyst maintains his positive outlook for the planned Phase III trial and the opportunity to establish a new standard of care for this sizable patient population. Catanzaro reiterates an Overweight rating and $36 price target on the shares.
03/10/19
PIPR
03/10/19
NO CHANGE
Target $35
PIPR
Overweight
NuCana shares 'significantly undervalued,' says Piper Jaffray
Piper Jaffray analyst Joseph Catanzaro is "incrementally more positive" around NuCana's "ambitious" development strategy for the ProTide platform after speaking to management. The analyst continues to believe that clinical data presented to date have fully supported ProTide's mechanism of action. Shares of NuCana are "significantly undervalued for the clear blockbuster potential" of NuCana's two lead assets, Catanzaro tells investors in a research note. He maintains an Overweight rating on the shares and trimmed his price target to $35 from $36.
06/02/19
PIPR
06/02/19
NO CHANGE
Target $35
PIPR
Overweight
NuCana pivotal BTC trial on-track to open in 2H19, says Piper Jaffray
Piper Jafrray analyst Joseph Catanzaro notes that NuCana provided a modest update to the Phase Ib studies looking at Acelarin in combination with platinum chemotherapy in ovarian and biliary tract cancer at ASCO with data largely consistent with prior updates. Enrollment into the pivotal Phase III BTC trial to evaluate Acelarin plus cisplatin is expected to begin in early 2H19, with final FDA sign-off on the protocol expected in the coming weeks, he notes. Catanzaro continues to believe that clinical data presented to date have fully supported Acelarin and the ProTide platform, and that Acelarin is well-positioned to establish a new standard of care in BTC. He reiterates an Overweight rating and $35 price target on the shares.

TODAY'S FREE FLY STORIES

01:55
10/24/19
10/24
01:55
10/24/19
01:55
General news
U.S. initial jobless claims preview: »

U.S. initial jobless…

01:55
10/24/19
10/24
01:55
10/24/19
01:55
General news
U.S. new home sales preview: w »

U.S. new home sales…

01:55
10/24/19
10/24
01:55
10/24/19
01:55
General news
U.S. durable goods preview: »

U.S. durable goods…

01:40
10/24/19
10/24
01:40
10/24/19
01:40
General news
Asian Market Update: »

Asian Market Update:…

GM

General Motors

$36.62

0.3 (0.83%)

21:16
10/23/19
10/23
21:16
10/23/19
21:16
Periodicals
Flint, Michigan UAW approves labor deal with General Motors, Bloomberg reports »

The vote was 61% in favor…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 29

    Oct

GLD

SPDR Gold Shares

$140.57

0.4 (0.29%)

20:29
10/23/19
10/23
20:29
10/23/19
20:29
Hot Stocks
SPDR Gold Shares holdings fall to 918.48MT from 919.66MT »

This is the second…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

CMCSA

Comcast

$45.74

-0.04 (-0.09%)

, CMCSK

Comcast

$0.00

(0.00%)

20:25
10/23/19
10/23
20:25
10/23/19
20:25
Earnings
Notable companies reporting before tomorrow's open »

Notable companies…

CMCSA

Comcast

$45.74

-0.04 (-0.09%)

CMCSK

Comcast

$0.00

(0.00%)

DHR

Danaher

$138.39

1.19 (0.87%)

MMM

3M

$168.62

1.06 (0.63%)

NOC

Northrop Grumman

$352.89

0.48 (0.14%)

RTN

Raytheon

$203.81

-1.08 (-0.53%)

BAX

Baxter

$87.90

0.87 (1.00%)

DOW

Dow Inc.

$47.29

0.47 (1.00%)

HSY

Hershey

$149.67

-0.06 (-0.04%)

TWTR

Twitter

$38.83

0.01 (0.03%)

LUV

Southwest

$53.27

0.375 (0.71%)

TROW

T. Rowe Price

$108.01

0.01 (0.01%)

SWK

Stanley Black & Decker

$153.73

2.42 (1.60%)

HBAN

Huntington Bancshares

$14.49

0.06 (0.42%)

CTXS

Citrix

$103.60

-0.5 (-0.48%)

TSCO

Tractor Supply

$95.02

0.8 (0.85%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 27

    Oct

  • 28

    Oct

  • 29

    Oct

  • 07

    Nov

  • 12

    Nov

  • 12

    Nov

  • 13

    Nov

  • 13

    Nov

  • 19

    Nov

  • 09

    Dec

  • 12

    Dec

AMZN

Amazon.com

$1,761.81

-4.26 (-0.24%)

20:22
10/23/19
10/23
20:22
10/23/19
20:22
Hot Stocks
Ceiva Logic sues Amazon for patent infringement »

CEIVA Logic announced it…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Oct

  • 24

    Oct

  • 27

    Oct

  • 29

    Oct

  • 21

    Nov

DLGNF

Dialog Semiconductor

$0.00

(0.00%)

20:17
10/23/19
10/23
20:17
10/23/19
20:17
Earnings
Dialog Semiconductor sees Q3 revenue $409M, up from prior $360M-$400M view »

As a result of the higher…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

HBMD

Howard Bancorp

$16.20

-0.23 (-1.40%)

19:17
10/23/19
10/23
19:17
10/23/19
19:17
Earnings
Howard Bancorp reports Q3 EPS 24c, two estimates 25c »

Reports Q3 NII $17.2M,…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

TSLA

Tesla

$254.93

-0.69 (-0.27%)

19:02
10/23/19
10/23
19:02
10/23/19
19:02
Hot Stocks
Tesla CFO says Model Y margins will be slightly higher than Model 3 »

Says Model Y cost…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Oct

PUB

People's Utah Bancorp

$28.93

-0.57 (-1.93%)

18:58
10/23/19
10/23
18:58
10/23/19
18:58
Earnings
People's Utah Bancorp reports Q3 EPS 59c, consensus 59c »

"People's Utah…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Oct

TSLA

Tesla

$254.93

-0.69 (-0.27%)

, MKSI

MKS Instruments

$94.65

-1.26 (-1.31%)

18:57
10/23/19
10/23
18:57
10/23/19
18:57
Hot Stocks
Fly Intel: After Hours Movers »

UP AFTER EARNINGS: Tesla…

TSLA

Tesla

$254.93

-0.69 (-0.27%)

MKSI

MKS Instruments

$94.65

-1.26 (-1.31%)

ALGN

Align Technology

$217.25

3.62 (1.69%)

FFIV

F5 Networks

$138.33

-0.71 (-0.51%)

MX

MagnaChip

$11.97

-0.2 (-1.64%)

PYPL

PayPal

$96.55

-0.85 (-0.87%)

LRCX

Lam Research

$233.22

-1.69 (-0.72%)

VAR

Varian Medical

$117.42

2.83 (2.47%)

NOW

ServiceNow

$220.01

-8.25 (-3.61%)

SAVE

Spirit Airlines

$37.73

0.48 (1.29%)

SEIC

SEI Investments

$57.20

-0.21 (-0.37%)

EW

Edwards Lifesciences

$224.58

2.66 (1.20%)

PTC

PTC

$66.91

1.07 (1.63%)

ORLY

O'Reilly Automotive

$400.49

-0.08 (-0.02%)

BMRN

BioMarin

$69.07

1.34 (1.98%)

CMRE

Costamare

$7.31

0.25 (3.54%)

SLM

Sallie Mae

$9.06

0.005 (0.06%)

CLB

Core Laboratories

$43.80

1.525 (3.61%)

AEM

Agnico Eagle

$54.09

1.03 (1.94%)

MSFT

Microsoft

$137.23

0.84 (0.62%)

NTGR

Netgear

$30.63

-1.32 (-4.13%)

FTI

TechnipFMC

$23.40

-0.1 (-0.43%)

EBAY

eBay

$39.22

0.25 (0.64%)

KRA

Kraton

$21.47

-0.51 (-2.32%)

F

Ford

$9.20

0.14 (1.55%)

MMLP

Martin Midstream Partners

$4.42

-0.03 (-0.67%)

XLNX

Xilinx

$93.83

-2.18 (-2.27%)

DHT

DHT Holdings

$7.68

0.3 (4.07%)

EFX

Equifax

$139.06

-0.2 (-0.14%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Oct

  • 23

    Oct

  • 23

    Oct

  • 23

    Oct

  • 23

    Oct

  • 23

    Oct

  • 23

    Oct

  • 23

    Oct

  • 23

    Oct

  • 23

    Oct

  • 23

    Oct

  • 23

    Oct

  • 23

    Oct

  • 23

    Oct

  • 23

    Oct

  • 23

    Oct

  • 23

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 24

    Oct

  • 26

    Oct

  • 27

    Oct

  • 28

    Oct

  • 29

    Oct

  • 29

    Oct

  • 29

    Oct

  • 30

    Oct

  • 30

    Oct

  • 31

    Oct

  • 04

    Nov

  • 05

    Nov

  • 06

    Nov

  • 08

    Nov

  • 12

    Nov

  • 13

    Nov

  • 14

    Nov

  • 15

    Nov

  • 19

    Nov

  • 20

    Nov

  • 20

    Nov

  • 21

    Nov

  • 21

    Nov

  • 21

    Nov

  • 07

    Dec

  • 09

    Dec

  • 09

    Dec

  • 09

    Dec

  • 12

    Dec

TSLA

Tesla

$254.93

-0.69 (-0.27%)

18:45
10/23/19
10/23
18:45
10/23/19
18:45
Hot Stocks
Tesla CFO says global order rate is 'strong and continues to increase' »

Says lower CapEx in Q3…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Oct

NOW

ServiceNow

$220.01

-8.25 (-3.61%)

, NKE

Nike

$92.30

-3.31 (-3.46%)

18:44
10/23/19
10/23
18:44
10/23/19
18:44
Hot Stocks
ServiceNow CEO: I have a twenty year relationship with Nike »

In an interview on…

NOW

ServiceNow

$220.01

-8.25 (-3.61%)

NKE

Nike

$92.30

-3.31 (-3.46%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Oct

  • 09

    Dec

  • 09

    Dec

  • 12

    Dec

TSLA

Tesla

$254.93

-0.69 (-0.27%)

18:40
10/23/19
10/23
18:40
10/23/19
18:40
Hot Stocks
Tesla CEO says self-driving 'appears to be on track' for release by year-end »

Says releasing version 3…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Oct

PKG

Packaging Corp.

$110.11

1.48 (1.36%)

18:40
10/23/19
10/23
18:40
10/23/19
18:40
Earnings
Packaging Corp. reports Q3 EPS ex-items $1.92, consensus $1.90 »

Reports Q3 revenue $1.8B,…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Oct

  • 13

    Nov

TSLA

Tesla

$254.93

-0.69 (-0.27%)

18:38
10/23/19
10/23
18:38
10/23/19
18:38
Hot Stocks
Tesla CEO says made great strides in controlling costs during Q3 »

Operating cost is lowest…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Oct

POOL

Pool Corp.

$206.03

-6.87 (-3.23%)

18:32
10/23/19
10/23
18:32
10/23/19
18:32
Hot Stocks
Pool Corp. CFO sells 5,000 common shares »

In a regulatory filing,…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Oct

  • 24

    Oct

  • 13

    Nov

GOOG

Alphabet

$1,259.62

16.835 (1.35%)

, GOOGL

Alphabet Class A

$1,257.88

16.8 (1.35%)

18:29
10/23/19
10/23
18:29
10/23/19
18:29
Periodicals
Google accused of building spy software curb worker dissent, Bloomberg says »

Google workers are…

GOOG

Alphabet

$1,259.62

16.835 (1.35%)

GOOGL

Alphabet Class A

$1,257.88

16.8 (1.35%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Oct

  • 27

    Oct

  • 28

    Oct

  • 28

    Oct

  • 29

    Oct

NFBK

Northfield Bancorp

$16.88

0.04 (0.24%)

18:18
10/23/19
10/23
18:18
10/23/19
18:18
Earnings
Northfield Bancorp reports Q3 EPS 28c, consensus 26c »

Reports Q3 revenue…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 13

    Nov

BRP

BRP Group

$0.00

(0.00%)

18:16
10/23/19
10/23
18:16
10/23/19
18:16
Syndicate
BRP Group 16.4M share IPO priced at $14.00 »

The deal priced at low…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Oct

GOOG

Alphabet

$1,259.62

16.835 (1.35%)

, GOOGL

Alphabet Class A

$1,257.88

16.8 (1.35%)

18:04
10/23/19
10/23
18:04
10/23/19
18:04
Periodicals
Google accused of building spy software curb worker dissent, Bloomberg says »

Google workers are…

GOOG

Alphabet

$1,259.62

16.835 (1.35%)

GOOGL

Alphabet Class A

$1,257.88

16.8 (1.35%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Oct

  • 27

    Oct

  • 28

    Oct

  • 28

    Oct

  • 29

    Oct

MSFT

Microsoft

$137.23

0.84 (0.62%)

18:03
10/23/19
10/23
18:03
10/23/19
18:03
Hot Stocks
Microsoft sees Q2 Productivity and Business Processes revenue $11.3B-$11.5B »

Sees Q2: Intelligent…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Oct

  • 26

    Oct

  • 27

    Oct

  • 29

    Oct

  • 06

    Nov

  • 14

    Nov

  • 21

    Nov

  • 09

    Dec

TSLA

Tesla

$254.93

-0.69 (-0.27%)

18:02
10/23/19
10/23
18:02
10/23/19
18:02
Hot Stocks
Breaking Hot Stocks news story on Tesla »

Tesla up 20.6% after…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Oct

Get Full Fly Access

Breaking market intelligence sent straight to you
Our team of experts analyze every news story and filter out the noise to deliver real-time market moving news.
Up-to-date information on important industry events
Get real-time updates on events that are moving the market—from conferences and calls to syndicate announcements.
News focused on the companies in your portfolio
Create up to 12 portfolios with 150 stocks each, and see how active they are in market news.