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ACHN

Achillion

$2.38

-0.03 (-1.24%)

07:05
07/22/19
07/22
07:05
07/22/19
07:05

Achillion announces results from Phase 1 MAD study of ACH-5228

Achillion Pharmaceuticals announced results from their Phase 1 multiple ascending dose study with ACH-5228 outside of the United States. In the randomized Phase 1 MAD study, ACH-5228 was administered to 43 healthy volunteers. Study subjects received oral doses of ACH-5228 ranging from 40 mg to 200 mg twice a day for fourteen days. The study also included a single dose cohort of 240 mg. The results demonstrated that ACH-5228, when dosed 120 mg BID or higher, achieved near complete and sustained Alternative Pathway inhibition with a mean value of greater than95% at steady state concentrations as measured by AP Hemolysis and AP Wieslab assays. The study demonstrated that ACH-5228 was generally well tolerated over the dose ranges tested, which include the doses expected to be evaluated in Phase 2 trials. The Company expects to submit an IND application to the U.S. Food and Drug Administration supporting clinical development for ACH-5228 in the fourth quarter of 2019.

  • 30

    Jul

ACHN Achillion
$2.38

-0.03 (-1.24%)

12/13/18
JMPS
12/13/18
NO CHANGE
Target $10
JMPS
Outperform
JMP says Achillion oral factor D update could renew interest in stock
JMP Securities analyst Liisa Bayko noted that Achillion's oral factor D inhibitor studies have been slow to enroll due to limited trial sites, but the company plans to update investors on its oral factor D portfolio this coming Monday, which she believes has the potential to renew interest in the stock. She is looking for updated data from first-gen oral factor D inhibitor ACH-4471 from four ongoing studies and the first Phase 1 data from next-gen factor D inhibitors, ACH-5228 and ACH-5548, adding that data that support activity in the C3G indication or in PNH "could reinvigorate interest." Bayko, who sees a blockbuster opportunity for an oral product in this category, keeps an Outperform rating and $10 price target on Achillion shares.
05/03/19
LEHM
05/03/19
DOWNGRADE
Target $2.5
LEHM
Underweight
Achillion downgraded to Underweight from Equal Weight at Barclays
Barclays analyst Geoffrey Meacham downgraded Achillion Pharmaceuticals to Underweight from Equal Weight and cut his price target for the shares to $2.50 from $5.
05/03/19
LEHM
05/03/19
DOWNGRADE
Target $2.5
LEHM
Underweight
Barclays downgrades Achillion to Underweight on lack of data catalysts
Barclays analyst Geoffrey Meacham downgraded Achillion Pharmaceuticals to Underweight from Equal Weight and cut his price target for the shares to $2.50 from $5. The analyst sees a lack of near- to mid-term catalysts that are capable of changing the story on the stock. He notes the downgrade has less to do with the underlying fundamentals of Achillion's Factor D program.
05/03/19
05/03/19
DOWNGRADE

Fly Intel: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Yeti (YETI) downgraded to Neutral from Buy at Goldman Sachs with analyst Alexandra Walvis saying the company's "strong" sales and brand momentum are now better understood by investors. 2. Electronic Arts (EA) downgraded to Neutral at MKM Partners on valuation with analyst Eric Handler saying the risk-reward on the stock appears to be "less compelling." 3. Cognizant (CTSH) downgraded to Market Perform from Outperform at William Blair, to Underweight from Neutral at JPMorgan, to Neutral from Buy at Goldman Sachs, to Perform from Outperform at Oppenheimer, to Sector Weight from Overweight at KeyBanc, to Neutral from Outperform at Wedbush and to Hold from Strong Buy at Needham after the company's earnings and guidance missed consensus estimates. 4. Target (TGT) downgraded to Market Perform from Outperform at Bernstein with analyst Brandon Fletcher saying he thinks Target's continued emphasis on growth over cost containment is a "less wise" stance at this point. 5. Achillion (ACHN) downgraded to Underweight from Equal Weight at Barclays with analyst Geoffrey Meacham seeing a lack of near- to mid-term catalysts that are capable of changing the story on the stock. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

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SFTBY

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CL

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BGNE

BeiGene

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2.61 (1.96%)

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CE

Celanese

$122.73

-1.06 (-0.86%)

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BA

Boeing

$379.33

-5.28 (-1.37%)

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AA

Alcoa

$21.70

-0.26 (-1.18%)

19:15
09/22/19
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19:15
Downgrade
Alcoa rating change at Goldman Sachs »

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AA

Alcoa

$21.70

-0.26 (-1.18%)

, SCHN

Schnitzer Steel

$23.55

-0.27 (-1.13%)

19:15
09/22/19
09/22
19:15
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19:15
Downgrade
Alcoa downgraded to Neutral from Buy at Goldman Sachs »

Goldman Sachs analyst…

AA

Alcoa

$21.70

-0.26 (-1.18%)

SCHN

Schnitzer Steel

$23.55

-0.27 (-1.13%)

CMC

Commercial Metals

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-0.42 (-2.29%)

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CMC

Commercial Metals

$17.94

-0.42 (-2.29%)

19:08
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19:08
Downgrade
Commercial Metals rating change at Goldman Sachs »

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SCHN

Schnitzer Steel

$23.55

-0.27 (-1.13%)

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19:06
Downgrade
Schnitzer Steel rating change at Goldman Sachs »

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FNSR

Finisar

$24.31

1.25 (5.42%)

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BNPQY

BNP Paribas

$0.00

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, DB

Deutsche Bank

$7.99

-0.08 (-0.99%)

18:04
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Periodicals
Deutsche Bank nearing deal to transfer prime assets to BNP, Reuters says »

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BNPQY

BNP Paribas

$0.00

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DB

Deutsche Bank

$7.99

-0.08 (-0.99%)

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VRSK

Verisk Analytics

$158.47

-0.21 (-0.13%)

18:00
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Initiation
Verisk Analytics initiated at Keefe Bruyette »

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T

AT&T

$37.92

0.78 (2.10%)

, CMCSA

Comcast

$46.36

-0.32 (-0.69%)

16:58
09/22/19
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On The Fly
Box Office Battle: 'Downton Abbey' wins weekend with $31M »

"Box Office Battle" is…

T

AT&T

$37.92

0.78 (2.10%)

CMCSA

Comcast

$46.36

-0.32 (-0.69%)

CMCSK

Comcast

$0.00

(0.00%)

SNE

Sony

$59.19

-0.19 (-0.32%)

LGF.A

Lionsgate

$9.49

-0.47 (-4.72%)

LGF.B

Lionsgate

$8.88

-0.435 (-4.67%)

DIS

Disney

$132.18

-1.14 (-0.86%)

VIAB

Viacom

$24.92

-0.28 (-1.11%)

VIA

Viacom

$26.67

-0.85 (-3.09%)

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VIVHY

Vivendi

$0.00

(0.00%)

, MDSO

Medidata

$91.77

-0.04 (-0.04%)

16:01
09/22/19
09/22
16:01
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Periodicals
Vivendi to widen legal battle against Mediaset beyond Italy, Reuters says »

Vivendi (VIVHY) is taking…

VIVHY

Vivendi

$0.00

(0.00%)

MDSO

Medidata

$91.77

-0.04 (-0.04%)

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SFTBY

SoftBank

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SoftBank

$0.00

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15:57
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15:57
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Periodicals
Some WeWork board members seeing to remove Neumann as CEO, WSJ says »

A bloc of WeWork…

SFTBY

SoftBank

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SFTBF

SoftBank

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WE

We Company

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SoftBank

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SoftBank

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SoftBank turns against WeWork's parent CEO, Reuters reports »

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SoftBank

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SoftBank

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WE

We Company

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VIAB

Viacom

$24.92

-0.28 (-1.11%)

, VIA

Viacom

$26.67

-0.85 (-3.09%)

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Viacom acquires exclusive cable rights to Seinfeld from Sony Pictures Television »

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VIAB

Viacom

$24.92

-0.28 (-1.11%)

VIA

Viacom

$26.67

-0.85 (-3.09%)

SNE

Sony

$59.19

-0.19 (-0.32%)

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PWR

Quanta Services

$37.61

-0.28 (-0.74%)

12:22
09/22/19
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12:22
Conference/Events
Quanta Services management to meet with Stephens »

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PTEN

Patterson-UTI

$9.66

0.01 (0.10%)

12:21
09/22/19
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12:21
Conference/Events
Patterson-UTI management to meet with Stephens »

Meeting to be held in Los…

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ESE

Esco Technologies

$78.44

-1.54 (-1.93%)

12:19
09/22/19
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12:19
Conference/Events
Esco Technologies management to meet with Stephens »

Meeting to be held in…

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CSGP

CoStar Group

$595.10

-3.87 (-0.65%)

12:16
09/22/19
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12:16
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12:16
Conference/Events
CoStar Group participates in a conference call with Stephens »

Conference call with CFO…

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CNNE

Cannae Holdings

$28.05

0.875 (3.22%)

12:02
09/22/19
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12:02
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12:02
Conference/Events
Cannae Holdings management to meet with Stephens »

Group Luncheon Meeting…

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ANDE

Andersons

$26.28

-0.56 (-2.09%)

12:01
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12:01
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12:01
Conference/Events
Andersons management to meet with Stephens »

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XGN

Exagen

$18.16

-0.425 (-2.29%)

, DDOG

Datadog

$36.20

-1.26 (-3.36%)

08:40
09/22/19
09/22
08:40
09/22/19
08:40
On The Fly
Opening Day: Datadog rises over 50% in market debut »

Shares of Datadog surged…

XGN

Exagen

$18.16

-0.425 (-2.29%)

DDOG

Datadog

$36.20

-1.26 (-3.36%)

PING

Ping Identity

$19.25

-0.8 (-3.99%)

IGMS

IGM Biosciences

$21.00

-0.7 (-3.23%)

NVST

Envista

$28.80

0.75 (2.67%)

PTON

Peloton

$0.00

(0.00%)

EDR

Endeavor

$0.00

(0.00%)

OPRT

Oportun Financial

$0.00

(0.00%)

WE

We Company

$0.00

(0.00%)

CSCO

Cisco

$49.59

0.38 (0.77%)

SFTBF

SoftBank

$0.00

(0.00%)

SFTBY

SoftBank

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PG

Procter & Gamble

$122.22

0.37 (0.30%)

, KO

Coca-Cola

$53.90

-0.62 (-1.14%)

08:17
09/21/19
09/21
08:17
09/21/19
08:17
Periodicals
Kellogg, Coca-Cola among staples stocks for dividends, Barron's says »

Consumer-staples stocks…

PG

Procter & Gamble

$122.22

0.37 (0.30%)

KO

Coca-Cola

$53.90

-0.62 (-1.14%)

PEP

PepsiCo

$134.49

-0.98 (-0.72%)

CL

Colgate-Palmolive

$70.97

0.01 (0.01%)

KMB

Kimberly-Clark

$135.13

0.9 (0.67%)

K

Kellogg

$63.79

0.07 (0.11%)

03/08/13
Wedge Partners
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CMCSA

Comcast

$46.36

-0.32 (-0.69%)

, CMCSK

Comcast

$0.00

(0.00%)

08:09
09/21/19
09/21
08:09
09/21/19
08:09
Periodicals
Facebook, Microsoft among growth stocks for risky times, Barron's says »

Comcast (CMCSA), Delta…

CMCSA

Comcast

$46.36

-0.32 (-0.69%)

CMCSK

Comcast

$0.00

(0.00%)

DAL

Delta Air Lines

$58.63

-0.05 (-0.09%)

FANG

Diamondback Energy

$96.90

-0.45 (-0.46%)

EHC

Encompass Health

$64.41

-0.01 (-0.02%)

FB

Facebook

$189.88

-0.27 (-0.14%)

JNJ

Johnson & Johnson

$131.73

1.75 (1.35%)

MSFT

Microsoft

$139.34

-1.74 (-1.23%)

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