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CYCN

Cyclerion Therapeutics

$8.73

0.31 (3.68%)

08:29
08/12/19
08/12
08:29
08/12/19
08:29

Cyclerion says Praliciguat Phase 2 studies remain on track for readouts in Q4

Praliciguat Phase 2 studies in patients with cardiometabolic diseases remain on track for two data readouts in Q4 2019. The ongoing Phase 2 study of praliciguat in patients with diabetic nephropathy is a randomized, placebo-controlled, dose-ranging study in 156 patients to evaluate safety and efficacy following 12 weeks of praliciguat treatment. Enrollment is complete. The primary measure of efficacy is the change in urine albumin to creatinine ratio. Effects on metabolic parameters will also be assessed as secondary endpoints. The ongoing Phase 2 study of praliciguat in patients with HFpEF is a randomized, placebo-controlled study in 196 patients to evaluate safety and efficacy following 12 weeks of praliciguat treatment. Enrollment is complete. The primary measure of efficacy is change in peak oxygen uptake as assessed by cardiopulmonary exercise testing (CPET), a quantitative measure of exercise capacity. Secondary efficacy measures include change in exercise capacity as assessed by the six-minute walk test, and change in patient-reported quality of life as assessed by the Kansas City Cardiomyopathy Questionnaire

  • 12

    Aug

CYCN Cyclerion Therapeutics
$8.73

0.31 (3.68%)

06/03/19
FBCO
06/03/19
INITIATION
Target $15
FBCO
Neutral
Cyclerion Therapeutics initiated with a Neutral at Credit Suisse
Credit Suisse analyst Martin Auster started coverage of Cyclerion Therapeutics with a Neutral rating and a $15 price target. The analyst believes that targeting difficult-to-treat diseases balanced by large commercial opportunities leads to high optionality in next 12-18 Months. The company's lead asset, olinciguat, is being studied in a Phase 2 to treat Sickle Cell Disease, he adds, noting that data supporting this approach in different diseases has been mixed.

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WMT

Walmart

$111.90

-0.11 (-0.10%)

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LB

L Brands

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ORCL

Oracle

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Facebook

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TSLA

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PDS

Precision Drilling

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-0.02 (-1.74%)

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PVTL

Pivotal Software

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VMware

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PACW

PacWest Bancorp

$33.83

0.56 (1.68%)

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CAAP

Corporacion America Airport

$5.81

0.295 (5.35%)

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Corporacion America Airport reports Q2 passenger traffic up 3.8% y/y »

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NVS

Novartis

$88.97

-1.23 (-1.36%)

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CAAP

Corporacion America Airport

$5.81

0.295 (5.35%)

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QFIN

360 Finance

$10.65

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TGI

Triumph Group

$22.70

0.19 (0.84%)

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DB

Deutsche Bank

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0.155 (2.21%)

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BNP Paribas

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MO

Altria Group

$46.57

0.32 (0.69%)

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AMZN

Amazon.com

$1,804.00

-19.19 (-1.05%)

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OXY

Occidental Petroleum

$44.69

-0.35 (-0.78%)

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LZB

La-Z-Boy

$31.52

1.48 (4.93%)

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HPQ

HP Inc.

$18.91

-0.04 (-0.21%)

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HCM

Hutchison China MediTech

$20.53

0.13 (0.64%)

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SMSEY

Samsonite International

$0.00

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04:55
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SERV

ServiceMaster

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