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MDCO

The Medicines Co.

$31.73

-0.91 (-2.79%)

08:09
08/15/19
08/15
08:09
08/15/19
08:09

The Medicines Co. Phase III trials have low prospect of failure, says Jefferies

Jefferies analyst Biren Amin sees a low prospect of failure for The Medicines Co.'s upcoming Orion Phase III trials. It is unlikely that the LDL benefit will deteriorate in the trial, Amin tells investors in a research note. The analyst also expects a "clean safety profile" that mirrors the marketed PCSK9 drugs. The likelihood of "good" data looks high, with potential share upside of 20%-25%, says the analyst. He keeps a Buy rating The Medicines Co. with a $44 price target.

MDCO The Medicines Co.
$31.73

-0.91 (-2.79%)

04/26/19
04/26/19
UPGRADE

Fly Intel: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Cleveland-Cliffs (CLF) upgraded to Outperform from Neutral at Credit Suisse with analyst Curt Woodworth saying he sees potential value near $16-$18 once the HBI plant is fully ramped, even with low hot-rolled coil prices at that point in time. 2. Argo Group (ARGO) upgraded to Outperform from Market Perform at William Blair with analyst Adam Klauber saying Argo is beginning to emerge as a long-term midcap growth insurer, Klauber tells investors in a research note. 3. Illinois Tool Works (ITW) upgraded to Neutral from Underweight at JPMorgan with analyst Ann Duignan saying following the company's "solid" Q1 results, downside risk to 2019 earnings estimates "appears limited," with the worst of auto builds and European weakness "likely behind us." 4. The Medicines Co. (MDCO) upgraded to Buy from Neutral at Goldman Sachs while Esperion (ESPR) upgraded to Neutral from Sell. 5. Shutterfly (SFLY) upgraded to Outperform from Market Perform at Raymond James with analyst Aaron Kessler citing stable Consumer segment growth trends and his expectation for improved consumer growth throughout 2019, as well as "very achievable" 2021 EBITDA guidance of $400M-$450M with modest organic growth assumptions and modest Lifetouch synergies baked in. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
05/02/19
SBSH
05/02/19
NO CHANGE
Target $23
SBSH
Buy
Amarin selloff creates attractive entry point, says Citi
Citi analyst Joel Beatty believes the selloff yesterday in shares of Amarin (AMRN) brings an attractive entry point. He raised his price target for the stock to $23 from $20 and keeps a Buy rating on the name. The analyst sees five potential upside catalysts this year, including a likely supportive ICER cost-effectiveness review and potential priority review from the FDA. Further, while an acquisition of Amarin is possible, the company acquiring The Medicines Co. (MDCO) or Esperion (ESPR) "could also be a viable path," says Beatty.
05/20/19
NOMU
05/20/19
NO CHANGE
Target $62
NOMU
Reduce
Alnylam partner presented limited safety data, says Nomura Instinet
Alnylam Pharmaceuticals' (ALNY) partner, the Medicines Company (MDCO), presented on Saturday data from the ORION-3 trial of inclisiran, Nomura Instinet analyst Christopher Marai tells investors in a research note. The update did not suggest any surprise safety signals, as expected, but only limited safety data, according to Marai. He believes inclisiran's opportunity is a "show-me story" and more likely to become priced in post-approval after material sales. The analyst reiterates a Reduce rating on Alnylam shares with a $62 price target.
05/20/19
BARD
05/20/19
NO CHANGE
Target $110
BARD
Outperform
The Medicines Co. price target raised to $110 from $80 at Baird
Baird analyst Madhu Kumar reiterated an Overweight rating on The Medicines Co and raised his price target to $110 from $80. On Saturday, the company announced Phase 2 open-label extension ORION-3 data for PCSK9 RNAi drug inclisiran for hypercholesterolemia at the National Lipid Association meeting, Kumar tells investors in a research note, adding that these results have increased his conviction in inclisiran "ascending the Iron Throne" of PCSK9 drugs in ORION-9/10/11, for which top-line data are guided for in the third quarter. Phase 2 OLE results, he says, have effectively quashed bear safety concerns for inclisiran.

TODAY'S FREE FLY STORIES

03:05
08/23/19
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03:05
General news
FX Update: The New Zealand dollar outperformed and China's yuan weakened »

FX Update: The New…

LLY

Eli Lilly

$111.63

0.2 (0.18%)

21:03
08/22/19
08/22
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21:03
Hot Stocks
Arbitration panel rules in favor of Eli Lilly in Adocia IP claim »

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FL

Foot Locker

$42.00

2.24 (5.63%)

, HIBB

Hibbett Sports

$17.01

0.845 (5.23%)

20:25
08/22/19
08/22
20:25
08/22/19
20:25
Earnings
Notable companies reporting before tomorrow's open »

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FL

Foot Locker

$42.00

2.24 (5.63%)

HIBB

Hibbett Sports

$17.01

0.845 (5.23%)

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RGR

Sturm, Ruger

$41.48

0.69 (1.69%)

, AOBC

American Outdoor Brands

$7.69

-0.01 (-0.13%)

19:40
08/22/19
08/22
19:40
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19:40
Hot Stocks
Trump 'hopeful' to work with Congress on' legislation addressing mass shootings »

President Donald Trump…

RGR

Sturm, Ruger

$41.48

0.69 (1.69%)

AOBC

American Outdoor Brands

$7.69

-0.01 (-0.13%)

VSTO

Vista Outdoor

$5.33

0.26 (5.13%)

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TOT

Total

$48.98

-0.18 (-0.37%)

19:16
08/22/19
08/22
19:16
08/22/19
19:16
Downgrade
Total rating change at Citi »

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KMPR

Kemper

$75.42

0.48 (0.64%)

19:14
08/22/19
08/22
19:14
08/22/19
19:14
Downgrade
Kemper rating change at William Blair »

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CRM

Salesforce

$148.26

0.86 (0.58%)

, INTU

Intuit

$276.05

-0.29 (-0.10%)

18:52
08/22/19
08/22
18:52
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18:52
Hot Stocks
Fly Intel: After Hours Movers »

UP AFTER EARNINGS: …

CRM

Salesforce

$148.26

0.86 (0.58%)

INTU

Intuit

$276.05

-0.29 (-0.10%)

PVTL

Pivotal Software

$13.69

0.01 (0.07%)

CBLK

Carbon Black

$24.52

1.77 (7.78%)

HPQ

HP Inc.

$18.91

-0.04 (-0.21%)

RAVN

Raven

$31.36

-0.87 (-2.70%)

VMW

VMware

$148.15

0.11 (0.07%)

ROST

Ross Stores

$107.31

1.63 (1.54%)

GPS

Gap

$17.75

0.79 (4.66%)

HAS

Hasbro

$114.35

-1.06 (-0.92%)

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TLND

Talend

$39.24

0.12 (0.31%)

18:45
08/22/19
08/22
18:45
08/22/19
18:45
Hot Stocks
Talend CEO: We solve the first mile in the data journey »

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BA

Boeing

$354.47

14.44 (4.25%)

18:40
08/22/19
08/22
18:40
08/22/19
18:40
Periodicals
FAA intends to test Boeing MAX software on newer pilots, Reuters says »

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DB

Deutsche Bank

$7.17

0.155 (2.21%)

18:32
08/22/19
08/22
18:32
08/22/19
18:32
Periodicals
Deutsche Bank to pay $16M to settle corruption charges with SEC, Reuters says »

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SPX

S&P 500

$0.00

(0.00%)

, SPY

SPDR S&P 500 ETF Trust

$292.36

-0.04 (-0.01%)

18:28
08/22/19
08/22
18:28
08/22/19
18:28
Periodicals
Kudlow says U.S., Chinese negotiators held productive trade talks, Reuters says »

White House economic…

SPX

S&P 500

$0.00

(0.00%)

SPY

SPDR S&P 500 ETF Trust

$292.36

-0.04 (-0.01%)

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GOOG

Alphabet

$1,188.53

-2.26 (-0.19%)

, GOOGL

Alphabet Class A

$1,190.41

0.15 (0.01%)

18:25
08/22/19
08/22
18:25
08/22/19
18:25
Hot Stocks
Google disabled 210 YouTube channels related to ongoing Hong Kong protests »

Google (GOOG) said in a…

GOOG

Alphabet

$1,188.53

-2.26 (-0.19%)

GOOGL

Alphabet Class A

$1,190.41

0.15 (0.01%)

FB

Facebook

$182.08

-1.48 (-0.81%)

TWTR

Twitter

$42.17

-0.63 (-1.47%)

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NUAN

Nuance

$17.31

-0.14 (-0.80%)

18:24
08/22/19
08/22
18:24
08/22/19
18:24
Syndicate
Nuance files Form 10 registration statement for planned spin-off of Cerence »

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CRM

Salesforce

$148.26

0.86 (0.58%)

18:23
08/22/19
08/22
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Hot Stocks
Salesforce co-CEO: We had a very strong second quarter »

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RVLT

Revolution Lighting

$0.34

-0.0124 (-3.57%)

18:10
08/22/19
08/22
18:10
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18:10
Hot Stocks
Revolution Lighting discloses additional delisting determination from Nasdaq »

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IBKC

Iberiabank

$70.16

-0.38 (-0.54%)

18:05
08/22/19
08/22
18:05
08/22/19
18:05
Hot Stocks
Iberiabank CEO Daryl Byrd sells over $840K in company shares »

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RMNI

Rimini Street

$4.77

-0.11 (-2.25%)

, ORCL

Oracle

$53.18

-0.08 (-0.15%)

18:02
08/22/19
08/22
18:02
08/22/19
18:02
Hot Stocks
San Fang Chemical switches to Rimini Street support for Oracle EBS »

Rimini Street (RMNI)…

RMNI

Rimini Street

$4.77

-0.11 (-2.25%)

ORCL

Oracle

$53.18

-0.08 (-0.15%)

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CRM

Salesforce

$148.26

0.86 (0.58%)

18:01
08/22/19
08/22
18:01
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18:01
Hot Stocks
Salesforce says Customer 360 will be huge growth driver over next decade »

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AAC

AAC Holdings

$0.60

-0.0327 (-5.17%)

17:57
08/22/19
08/22
17:57
08/22/19
17:57
Hot Stocks
AAC Holdings discloses NYSE listing notice »

AAC Holdings announced…

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17:32
08/22/19
08/22
17:32
08/22/19
17:32
General news
Fed Balance Sheet Level data reported »

Week of 8/21 Fed Balance…

HPQ

HP Inc.

$18.91

-0.04 (-0.21%)

17:30
08/22/19
08/22
17:30
08/22/19
17:30
Hot Stocks
HP Inc. says notebooks accounted for 39% of revenue in Q3 »

Says supplies category…

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17:28
08/22/19
08/22
17:28
08/22/19
17:28
General news
Money Supply M2 Weekly Change data reported »

Week of 8/12 Money Supply…

TRPX

Therapix Biosciences

$2.35

(0.00%)

17:27
08/22/19
08/22
17:27
08/22/19
17:27
Syndicate
Breaking Syndicate news story on Therapix Biosciences »

Therapix Biosciences…

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GLD

SPDR Gold Shares

$141.38

-0.36 (-0.25%)

17:26
08/22/19
08/22
17:26
08/22/19
17:26
Hot Stocks
SPDR Gold Shares holdings rise to 854.84MT to 851.91MT »

This is the third…

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VMW

VMware

$148.15

0.11 (0.07%)

17:19
08/22/19
08/22
17:19
08/22/19
17:19
Earnings
VMware sees Q3 adjusted EPS $1.42, consensus $1.57 »

Sees Q3 revenue growth…

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