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FULC

Fulcrum Therapeutics

$9.11

-0.14 (-1.51%)

07:01
08/19/19
08/19
07:01
08/19/19
07:01

Fulcrum Therapeutics intitiates Phase 2b clinical trial of losmapimod for FSHD

Fulcrum Therapeutics announced it has initiated ReDUX4, a Phase 2b clinical trial of losmapimod in facioscapulohumeral muscular dystrophy. The clinical trial is designed to evaluate the efficacy and safety of losmapimod, an investigational selective p38alpha/beta MAPK inhibitor, in addressing the underlying cause of FSHD, a rare, progressive and disabling muscular dystrophy. The multicenter trial is a randomized, double-blind, placebo-controlled, 24-week study of losmapimod, and will enroll patients with genetically confirmed FSHD. The primary endpoint of the study is to evaluate the efficacy of losmapimod in inhibiting or reducing DUX4-driven gene expression. DUX4 expression will be measured by a subset of DUX4-regulated gene transcripts in skeletal muscle biopsies. Clinical data are expected in the third quarter of 2020. In parallel, Fulcrum will also initiate a 52-week open label study, which will include interim analyses.

FULC Fulcrum Therapeutics
$9.11

-0.14 (-1.51%)

08/12/19
BOFA
08/12/19
INITIATION
Target $19
BOFA
Buy
Fulcrum Therapeutics initiated with a Buy at BofA/Merrill
BofA/Merrill analyst Tazeen Ahmad started Fulcrum Therapeutics with a Buy rating and $19 price target. The company's approach to developing small molecule inhibitors that target underlying disease pathology has advantages relative to other emerging treatments, Ahmad tells investors in a research note. The analyst sees curative potential in multiple therapeutic areas.
08/12/19
MSCO
08/12/19
INITIATION
Target $29
MSCO
Overweight
Fulcrum Therapeutics initiated with an Overweight at Morgan Stanley
Morgan Stanley analyst Matthew Harrison initiated Fulcrum Therapeutics with an Overweight rating and $29 price target, stating that he sees lead compound losmapimod having high probability of success as a potential first treatment for a market worth greater than $2B treating facioscapulohumeral muscular dystrophy. Additionally, Harrison believes Fulcrum's target discovery platform can find new targets and help the company build "a robust pipeline," he tells investors.

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IIPR

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Cision

$10.08

1.63 (19.29%)

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LOGI

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HAS

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XOM

Exxon Mobil

$69.11

0.37 (0.54%)

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XOM

Exxon Mobil

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0.37 (0.54%)

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TER

Teradyne

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TER

Teradyne

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GVA

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REZI

Resideo

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0.03 (0.20%)

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REZI

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KFS

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$2.23

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REZI

Resideo

$15.17

0.03 (0.20%)

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REZI

Resideo

$15.17

0.03 (0.20%)

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REZI

Resideo

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0.03 (0.20%)

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HNGR

Hanger

$20.50

0.39 (1.94%)

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Rudolph Technologies

$27.36

-0.12 (-0.44%)

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HNGR

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$20.50

0.39 (1.94%)

RTEC

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$27.36

-0.12 (-0.44%)

NANO

Nanometrics

$34.01

0.03 (0.09%)

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PSB

PS Business Parks

$184.20

-1.53 (-0.82%)

17:11
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Earnings
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EPSN

Epsilon Energy

$3.20

(0.00%)

17:06
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CALX

Calix

$7.15

0.005 (0.07%)

17:06
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Earnings
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NOW

ServiceNow

$228.26

-12.315 (-5.12%)

17:05
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