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FULC

Fulcrum Therapeutics

$9.11

-0.14 (-1.51%)

07:01
08/19/19
08/19
07:01
08/19/19
07:01

Fulcrum Therapeutics intitiates Phase 2b clinical trial of losmapimod for FSHD

Fulcrum Therapeutics announced it has initiated ReDUX4, a Phase 2b clinical trial of losmapimod in facioscapulohumeral muscular dystrophy. The clinical trial is designed to evaluate the efficacy and safety of losmapimod, an investigational selective p38alpha/beta MAPK inhibitor, in addressing the underlying cause of FSHD, a rare, progressive and disabling muscular dystrophy. The multicenter trial is a randomized, double-blind, placebo-controlled, 24-week study of losmapimod, and will enroll patients with genetically confirmed FSHD. The primary endpoint of the study is to evaluate the efficacy of losmapimod in inhibiting or reducing DUX4-driven gene expression. DUX4 expression will be measured by a subset of DUX4-regulated gene transcripts in skeletal muscle biopsies. Clinical data are expected in the third quarter of 2020. In parallel, Fulcrum will also initiate a 52-week open label study, which will include interim analyses.

FULC Fulcrum Therapeutics
$9.11

-0.14 (-1.51%)

08/12/19
BOFA
08/12/19
INITIATION
Target $19
BOFA
Buy
Fulcrum Therapeutics initiated with a Buy at BofA/Merrill
BofA/Merrill analyst Tazeen Ahmad started Fulcrum Therapeutics with a Buy rating and $19 price target. The company's approach to developing small molecule inhibitors that target underlying disease pathology has advantages relative to other emerging treatments, Ahmad tells investors in a research note. The analyst sees curative potential in multiple therapeutic areas.
08/12/19
MSCO
08/12/19
INITIATION
Target $29
MSCO
Overweight
Fulcrum Therapeutics initiated with an Overweight at Morgan Stanley
Morgan Stanley analyst Matthew Harrison initiated Fulcrum Therapeutics with an Overweight rating and $29 price target, stating that he sees lead compound losmapimod having high probability of success as a potential first treatment for a market worth greater than $2B treating facioscapulohumeral muscular dystrophy. Additionally, Harrison believes Fulcrum's target discovery platform can find new targets and help the company build "a robust pipeline," he tells investors.

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RAMP

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EPAM

Epam Systems

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FB

Facebook

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CTSH

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XLNX

Xilinx

$103.59

-1.3 (-1.24%)

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SAIC

SAIC

$83.88

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LDOS

Leidos

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CACI

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BAH

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GIB

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ACN

Accenture

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COST

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NXST

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, TRCO

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SMTX

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ENLAY

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