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RCKT

Rocket Pharmaceuticals

$11.44

0.115 (1.02%)

07:09
08/22/19
08/22
07:09
08/22/19
07:09

Rocket Pharmaceuticals announces clearance to commence Phase 2 FANCOLEN-II trial

Rocket Pharmaceuticals announced clearance from the Spanish Agency for Medicines and Health Products to commence enrollment in the FANCOLEN-II Phase 2 registration-enabling study of RP-L102 for Fanconi Anemia, or FA, in Spain. The European Medicines Agency, or EMA, agreed to several key elements of the open-label Phase 2 trial, including endpoints that are designed to demonstrate reversion of the sensitivity of hematopoietic cells to DNA-damaging agents. The primary endpoint of the trial is the emergence of mitomycin-C, or MMC, resistance in bone marrow colony forming cells. A surrogate endpoint is a diepoxybutane, or DEB, chromosomal stability of peripheral blood T-lymphocytes. Sensitivity to DNA-damaging agents is a phenotypic hallmark of FA. Additional outcomes include stability or increase in blood counts with no significant worsening in anemia, neutropenia or thrombocytopenia and peripheral blood genetic correction, as demonstrated by vector copy number, or VCN, including progressive increases in peripheral blood VCN over the months subsequent to infusion. The open-label Phase 2 clinical trial will enroll up to five pediatric patients in Europe. The study will enroll younger patients who have not developed severe bone marrow failure. The patients will receive a single intravenous infusion of RP-L102 that utilizes "Process B" which incorporates enhanced stem cell enrichment, transduction enhancers and commercial-grade vector and manufacturing without the use of any conditioning treatment. The study is designed to assess the benefit/risk profile of RP-L102.

  • 09

    Sep

RCKT Rocket Pharmaceuticals
$11.44

0.115 (1.02%)

03/15/19
BOFA
03/15/19
INITIATION
Target $27
BOFA
Buy
Rocket Pharmaceuticals initiated with a Buy at BofA/Merrill
BofA/Merrill analyst Ying Huang initiated Rocket Pharmaceuticals with a Buy and $27 price target citing encouraging clinical and preliminary clinical results in the company's disease gene therapy pipeline.
03/15/19
03/15/19
INITIATION

Fly Intel: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Simmons First National (SFNC) initiated with a Buy at DA Davidson. 2. Amgen (AMGN) and Gilead (GILD) initiated with an Outperform at BMO Capital. 3. Rocket Pharmaceuticals (RCKT) initiated with a Buy at BofA/Merrill. 4. Urovant Sciences (UROV) initiated with a Buy at SunTrust. 5. Spectrum (SPPI) assumed with a Buy at Jefferies. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
04/22/19
BARD
04/22/19
INITIATION
Target $28
BARD
Outperform
Rocket Pharmaceuticals initiated with an Outperform at Baird
Baird analyst Madhu Kumar started Rocket Pharmaceuticals with an Outperform rating and $28 price target.
04/22/19
BARD
04/22/19
INITIATION
BARD
Outperform
Rocket Pharmaceuticals initiated with an Outperform at Baird
Baird analyst Madhu Kumar initiated Rocket Pharmaceuticals with an Outperform rating and a $28 price target, with the analyst saying that lentiviral gene therapy RP-L102 for the treatment of Fanconi anemia type A, which is currently in Phase 1/2 with data expected in the second half of the year, could serve as a "key catalyst" for the stock.

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CAL

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UNVR

Univar

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SGMS

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CLPHY

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  • 19

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CBAY

CymaBay

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  • 23

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AMR

Alta Mesa Resources

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MGA

Magna

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FB

Facebook

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TTWO

Take-Two

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IOTS

Adesto Technologies

$10.63

-0.66 (-5.85%)

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Syndicate
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ADBE

Adobe

$284.59

1.54 (0.54%)

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Adobe sees FY19 digital experience bookings growth greater than 20% »

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JCAP

Jernigan Capital

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CHWY

Chewy

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VRTS

Virtus Investment

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YUM

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CGC

Canopy Growth

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  • 26

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VIX

Volatility Index S&P 500 Options

$0.00

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IOTS

Adesto Technologies

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PZZA

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ATRO

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