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KURA

Kura Oncology

$15.10

-0.18 (-1.18%)

07:31
09/03/19
09/03
07:31
09/03/19
07:31

Kura Oncology announces results from Phase 2 trial of tipifarnib

Kura Oncology announced topline results from an investigator-sponsored Phase 2 trial of its lead drug candidate, tipifarnib, in patients with relapsed or refractory urothelial carcinomas that carry HRAS mutations. The ongoing, single-agent, single-arm trial is designed to enroll at least 18 patients, with a primary endpoint of progression-free survival rate at 6 months. Secondary endpoints include objective response rate, duration of response and safety. The trial is being conducted at the Samsung Medical Center in Korea. To date, more than 200 patients with relapsed or refractory urothelial carcinoma have been screened for the presence of tumor HRAS mutations. A total of 15 patients were identified to carry tumors with HRAS mutations. Two patients withdrew from the trial prior to their first response assessment. Of the 13 evaluable patients, five experienced confirmed objective responses, according to RECIST 1.1 criteria, for an overall response rate of 38%. Notably, four patients have experienced PFS of greater than 6 months. According to the trial protocol, the primary endpoint is met when at least four patients achieve PFS at 6 months. All patients joined the trial upon progression from at least one prior systemic chemotherapy cycle, with a median of one prior therapy. Tipifarnib has been generally well-tolerated in the trial; adverse events observed are consistent with the known safety profile of tipifarnib. Further analyses of the trial are ongoing, and detailed data are expected to be presented at a future medical meeting.

  • 04

    Sep

  • 09

    Sep

KURA Kura Oncology
$15.10

-0.18 (-1.18%)

05/24/19
SBSH
05/24/19
NO CHANGE
Target $25
SBSH
Buy
Kura Oncology price target raised to $25 from $18 at Citi
Citi analyst Joel Beatty raised his price target for Kura Oncology to $25 from $18 saying he believes the data to date support that tipifarnib is likely effective for HRAS-mutant head and neck squamous cell carcinoma. More Phase 2 data in this setting in the second half of 2019 could add further support, Beatty tells investors in a research note. He keeps a Buy rating on Kura Oncology shares.
06/14/19
HCWC
06/14/19
NO CHANGE
Target $31
HCWC
Buy
Kura reported 'crucial' biomarker set of data, says H.C. Wainwright
H.C. Wainwright analyst Joseph Pantginis maintained a Buy rating and $31 price target on Kura Oncology after the company announced positive follow-up data from the ongoing Phase 2 clinical trial addressing the anti-tumor role of tipifarnib in PTCL patients and met the primary endpoint. In a research note to investors, the analyst says Kura reported a crucial biomarker set of data, the enrichment of high rate of mutation/variation of the killer cell immunoglobulin-like receptors, including KIR3DL2 in AITL patients and its role in tipifarnib outcome. Kura's targeted approaches could generate fast and meaningful information on crucial tumor indications and patient cohorts where tipifarnib may see more robust clinical outcomes, increasing his confidence on tipifarnib's likelihood of success, the analyst contends.
06/17/19
WEDB
06/17/19
NO CHANGE
Target $30
WEDB
Outperform
Kura Oncology price target raised to $30 from $23 at Wedbush
Wedbush analyst Robert Driscoll raised his price target for Kura Oncology to $30 from $23 after the company announced positive data from an ongoing Phase 2 study evaluating tipifarnib in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma patients carrying a CXCL12 3' UTR SNP. Overall, the analyst views the "impressive" data set as highly supportive of a registrational pathway in AITL/PTCL CXCL12+ patients, and further validating of the broadening clinical development of tipifarnib into additional indications to potentially include pancreatic, DLBCL, and AML. Driscoll reiterates an Outperform rating on the shares.
07/18/19
DBAB
07/18/19
INITIATION
Target $28
DBAB
Buy
Kura Oncology initiated with a Buy at Deutsche Bank
Deutsche Bank analyst Konstantinos Aprilakis started Kura Oncology with a Buy rating and $28 price target. The analyst initiated coverage on eight smid-cap Biotechnology stocks in the oncology space.

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CVS

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DDAIF

Daimler AG

$0.00

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F

Ford

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GM

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Nissan

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ADM

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UPS

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DIS

Disney

$132.18

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, T

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Disney

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T

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BA

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MCF

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GLD

SPDR Gold Shares

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VXRT

Vaxart

$0.58

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AAPL

Apple

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IIVI

II-VI

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, CPE

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CPE

Callon Petroleum

$4.53

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PSMT

PriceSmart

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FNSR

Finisar

$24.31

1.25 (5.42%)

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NVR

NVR

$3,632.55

-30.45 (-0.83%)

, JEF

Jefferies Financial Group

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-0.19 (-0.97%)

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NVR to replace Jefferies Financial Group in the S&P 500 at open on September 26 »

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NVR

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$3,632.55

-30.45 (-0.83%)

JEF

Jefferies Financial Group

$19.47

-0.19 (-0.97%)

SPB

Spectrum Brands

$49.66

-1.395 (-2.73%)

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NOC

Northrop Grumman

$368.25

-7.45 (-1.98%)

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PSMT

PriceSmart

$60.29

-0.39 (-0.64%)

, FNSR

Finisar

$24.31

1.25 (5.42%)

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PSMT

PriceSmart

$60.29

-0.39 (-0.64%)

FNSR

Finisar

$24.31

1.25 (5.42%)

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IIVI

II-VI

$39.05

-0.5 (-1.26%)

, CPE

Callon Petroleum

$4.53

-0.015 (-0.33%)

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IIVI

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CPE

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$4.53

-0.015 (-0.33%)

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NVR

NVR

$3,632.55

-30.45 (-0.83%)

17:20
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Breaking Hot Stocks news story on NVR »

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NHYDY

Norsk Hydro

$0.00

(0.00%)

17:12
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RESN

Resonant

$3.05

0.02 (0.66%)

17:03
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17:03
Conference/Events
Resonant participates in a conference call with Loop Capital »

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NINE

Nine Energy Services

$6.73

-0.33 (-4.67%)

17:02
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Syndicate
Breaking Syndicate news story on Nine Energy Services »

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ATOM

Atomera

$3.70

0.17 (4.82%)

17:00
09/20/19
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17:00
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17:00
Conference/Events
Atomera participates in a conference call with Loop Capital »

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MPWR

Monolithic Power

$154.21

-2 (-1.28%)

16:50
09/20/19
09/20
16:50
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16:50
Conference/Events
Monolithic Power participates in a conference call with Loop Capital »

Semiconductor Analysts…

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