Lineage Cell Therapeutics announces publication of stem cells paper
Lineage Cell Therapeutics announced that its paper entitled "Transplantation of Human Embryonic Stem Cell Derived Retinal Tissue in the Subretinal Space of the Cat Eye,", has been selected for publishing and will be featured on the cover of the September 2019 issue of Stem Cells and Development Journal, Volume 28, Number 17. In this preclinical model, researchers demonstrated that human pluripotent stem cell-derived retinal tissue was successfully introduced and delivered into the subretinal space of a large eye model following a pars plana vitrectomy. Researchers optimized the immunosuppression regimen to enable the grafts to survive for several weeks. In addition, the team demonstrated tumor-free maturation of the transplanted stem cell-derived retinal tissue and establishment of graft-host axonal connectivity and graft-host synaptic connectivity. Grafts connectivity with host neural cells of the retina is an essential anatomical requirement after transplantation, which could facilitate functional vision improvement.