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TPTX

Turning Point Therapeutics

$51.03

-3.38 (-6.21%)

16:15
09/03/19
09/03
16:15
09/03/19
16:15

Turning Point Therapeutics announced updated data on repotrectinib

Turning Point Therapeutics announced updated interim data from the Phase 1 portion of its ongoing Phase 1/2 TRIDENT-1 clinical study of lead drug candidate repotrectinib in patients with ROS1-positive non-small cell lung cancer,NSCLC,and TRK-positive patients with advanced solid tumors. The company also announced potent preclinical activity for its novel RET/SRC drug candidate, TPX-0046, in wild type and mutated RET fusions compared to proxy chemical compounds for investigational RET inhibitors."With each additional update of the ongoing Phase 1 clinical data, repotrectinib continues to encourage us with what we believe is best-in-class potential for patients with ROS1-positive advanced non-small cell lung cancer," said Athena Countouriotis, M.D., president and chief executive officer. "The preliminary data are also encouraging in the TRK-positive population where we have treated fewer patients but today reported our first confirmed response in a TKI-naive patient. With two ROS1-positive patients remaining on treatment for more than 2 years, we believe the results we announced today further distinguish repotrectinib, and are supportive of our ongoing, multi-cohort registrational Phase 2 TRIDENT-1 Study."With TPX-0046, we have demonstrated strong preclinical potency in Ba/F3 cells with the mutated KIF5B RET fusion gene and against multiple solvent front mutations that may arise from other investigational RET inhibitors and lead to treatment resistance. We believe these results position TPX-0046 for potential use in TKI-naive patients as well as those who have developed treatment resistance with solvent front mutations. Subject to clearance of the IND, we look forward to initiating our planned clinical trial later this year."

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TPTX Turning Point Therapeutics
$51.03

-3.38 (-6.21%)

05/13/19
ADAM
05/13/19
INITIATION
Target $48
ADAM
Buy
Turning Point Therapeutics initiated with a Buy at Canaccord
Canaccord analyst Arlinda Lee initiated Turning Point Therapeutics with a Buy rating and $48 price target, telling investors in a research note that she views lead drug candidate repotrectinib's early but notable clinical and intercranial effect in frontline and refractory cancer patients as validation of Turning Point's macrocycle platform.
05/13/19
05/13/19
INITIATION

Fly Intel: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Pinterest (PINS) initiated with an Outperform at Baird, a Buy at Citi, a Sector Perform at RBC Capital, a Hold at Deutsche Bank, a Neutral at Credit Suisse, UBS, BofA/Merrill, Goldman Sachs, and JPMorgan, and an Equal Weight at Barclays. 2. Zoom Video (ZM) initiated with an Overweight at JPMorgan and Piper Jaffray, a Buy at BofA/Merrill, a Market Perform at Wells Fargo and JMP Securities, a Sector Perform at RBC Capital, a Sector Weight at KeyBanc, an Equal Weight at Morgan Stanley, a Hold at Stifel, and a Neutral at Credit Suisse and Goldman Sachs. 3. Turning Point Therapeutics (TPTX) initiated with an Outperform at Wells Fargo and a Buy at Canaccord and Goldman Sachs. 4. Brigham Minerals (MNRL) initiated with an Overweight at Piper Jaffray and Barclays, an Outperform at Wells Fargo, RBC Capital, and Credit Suisse, and a Buy at Goldman Sachs and UBS. 5. Brainsway (BWAY) initiated with an Outperform at Raymond James and Oppenheimer, a Buy at Ladenburg, and Overweight at Cantor Fitzgerald. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
07/24/19
GUGG
07/24/19
INITIATION
Target $58
GUGG
Buy
Turning Point Therapeutics initiated with a Buy at Guggenheim
Guggenheim analyst Michael Schmidt initiated coverage of Turning Point Therapeutics with a Buy rating and $58 price target, stating that the market for selective tyrosine kinase inhibitors, or TKIs, targeting rare driver mutations in oncology represents a large and growing opportunity. The company's lead product candidate, repotrectinib, has demonstrated early but potent activity in certain non-small cell lung cancer patients positive and may be a best-in-class inhibitor for some solid tumor patients, Schmidt said.
07/24/19
07/24/19
INITIATION

Fly Intel: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Sharps Compliance (SMED) initiated with a Buy at Roth Capital. 2. MobileIron (MOBL) initiated with a Buy at Craig-Hallum. 3. Berry Global (BERY) resumed with an Outperform at Wells Fargo. 4. Turning Point Therapeutics (TPTX) initiated with a Buy at Guggenheim. 5. Universal Display (OLED) initiated with a Hold at Berenberg. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.

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