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ATNX

Athenex

$14.05

0.33 (2.41%)

07:02
09/11/19
09/11
07:02
09/11/19
07:02

Athenex announces initiation of Phase 1 clinical study of KX2-361 in China

Athenex announced that its partner, Guangzhou Xiangxue Pharmaceutical Co., Ltd., initiated a Phase I study in China of KX2-361 oral treating advanced malignant solid tumors. KX2-361, which is being developed for the treatment of glioblastoma multiforme, is the second compound derived from Athenex's Src kinase inhibition platform. It is a closely related structural analog of Athenex's tirbanibulin with a distinct ability to cross the blood brain barrier, making it a potential therapeutic candidate for treating brain cancers, including GBM, as well as brain metastases. Studies of KX2-361 oral in preclinical mouse GBM tumor models resulted in complete tumor eradication as well as extended survival compared to the current standard of care, temozolomide. The Phase I clinical study in China is a single-center, open-label dose escalation trial that will enroll 36-72 patients with advanced malignant solid tumors who have no standard treatment or standard treatment failed.

ATNX Athenex
$14.05

0.33 (2.41%)

03/29/19
RHCO
03/29/19
INITIATION
Target $20
RHCO
Buy
Athenex initiated with a Buy at SunTrust
SunTrust analyst Peter Lawson initiated Athenex with a Buy and $20 price target, saying he is positive on the company's "hydra-like" approach to killing cancer with T-cell, Kinases, and improved chemo therapies. Among the catalysts, the analyst notes that Athenex should have two New Drug Applications by the second half of 2020 with a sales force already in place and also points to its mid-2019 Phase 3 data for oral-chemo candidate Oraxol that "looks de-risked based on Phase 2 data." Lawson also believes that risk-reward on Athenex is positive for the next 12 months with shares trading below IPO levels.
07/30/19
RHCO
07/30/19
NO CHANGE
Target $30
RHCO
Buy
Athenex price target raised to $30 from $20 at SunTrust
SunTrust analyst Peter Lawson raised his price target on Athenex to $30 and kept his Buy rating. The analyst is rolling the company's existing pharmaceutical division product revenues into his valuation model while also assigning an 80% likelihood of success ahead of its upcoming Oraxol data.
08/07/19
RHCO
08/07/19
NO CHANGE
Target $30
RHCO
Buy
Athenex's paclitaxel phase 3 data 'positive' for NDA and pipeline, says SunTrust
SunTrust analyst Peter Lawson is keeping his Buy rating and $30 price target on Athenex after the company announced that its Oral paclitaxel and encequidar met primary endpoint in a Phase 3 study with a "very encouraging" readout relative to IV paclitaxel. The analyst notes that the overall response rate of 36% in the Oral version exceeded the 24% for IV and came in better than "over 30%" that he expected. Lawson adds that the "encouraging" topline data should support a New Drug Application filing and the development of other oral chemo programs.
08/07/19
RBCM
08/07/19
NO CHANGE
Target $31
RBCM
Outperform
Athenex's Oraxol data 'near best-case,' says RBC Capital
Athenex announced results from the phase 3 trial of Oraxol in metastatic breast cancer patients that "approach a best case scenario," according to RBC Capital analyst Kennen MacKay, who views these data as demonstrating outstanding efficacy, durability, and safety/tolerability improvement. He models Oraxol achieving peak risk-unadjusted U.S. sales of $1B and global sales of $1.5B in metastatic breast cancer, noted MacKay, who expects the stock to trade to roughly $30 per share following the data. He keeps an Outperform rating and $31 price target on Athenex shares.

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