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AMGN

Amgen

$195.00

-0.73 (-0.37%)

15:15
09/12/19
09/12
15:15
09/12/19
15:15

Amgen says Phase 1 dose escalation clinical trial for AMG 397 on clinical hold

Beore the market open, Amgen disclosed that the Phase 1 dose escalation clinical trial for AMG 397 is on a clinical hold to evaluate a safety signal for cardiac toxicity. In keeping with Amgen's commitment to patient safety, the AMG 176 Phase 1 trial has been placed on a voluntary hold for new enrollment.

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AMGN Amgen
$195.00

-0.73 (-0.37%)

09/08/19
PIPR
09/08/19
NO CHANGE
Target $218
PIPR
Overweight
Amgen '510 continues to look like 'a gamechanger,' says Piper Jaffray
Piper Jaffray analyst Christopher Raymond reiterates an Overweight rating and a $218 price target on Amgen shares after the latest update on AMG 510 at World Lung. The analyst believes AMG 510 continues to look like a gamechanger in KRAS-G12C mutant NSCLC. He awaits an additional update at ESMO before formally layering AMG 510 into his model.
09/09/19
JEFF
09/09/19
UPGRADE
Target $105
JEFF
Buy
Mirati Therapeutics upgraded to Buy from Hold at Jefferies
Jefferies analyst Maury Raycroft upgraded Mirati Therapeutics (MRTX) to Buy from Hold and raised his price target for the shares to $105 from $89. The analyst believes the bar for initial Mirati data has been lowered after Amgen (AMGN) announced new data from the ongoing Phase 1 study evaluating AMG 510 in patients with previously treated KRAS G12C-mutated solid tumors. Pharmacokinetic variability could become a liability for Amgen, which opens the window wider for Mirati's MRTX849 to be "best-in-class," Raycroft tells investors in a research note.
09/09/19
CANT
09/09/19
NO CHANGE
Target $81
CANT
Neutral
Cantor warrants caution on Mirati after Amgen data, sees 7%-11% selloff
Cantor Fitzgerald analyst Varun Kumar warrants caution on shares of Mirati Therapeutics (MRTX) ahead of its MRTX849 data following Amgen's (AMGN) update from its KRAS G12C program, AMG 510. Updated response rates data "are not a 'slam dunk' as may have been broadly expected, and further follow-up is needed for a more-matured verdict," Kumar tells investors in a research note. Further, durability will likely be the talking point in the near term, as KRASi G12C market size needs to be carefully assessed versus what's currently reflected by market estimates, adds the analyst. He thinks Mirati shares could trade down 7%-11% given some caution on the response rate trend as the cohort size gets larger and due to an increasing focus on response durability, which he thinks may change the U.S. peak sales estimates for KRAS G12C non-small-cell lung carcinoma market to $1.8B-$3.6B. Kumar lowered his price target for Mirati Therapeutics to $81 from $85 and reiterates a Neutral rating on the name. The stock in premarket trading is down 4% to $87.27. Jefferies this morning upgraded the shares to Buy following Amgen's data.
09/09/19
JEFF
09/09/19
NO CHANGE
Target $235
JEFF
Buy
Jefferies sees blockbuster drug for Amgen, says buy shares on selloff
Amgen's new lung data shows a 54% overall response rate at the high dose, which is "very strong," yet at the lower end of Street expectations, Jefferies analyst Michael Yee tells investors in a research note. The analyst says his thesis remains "very positive" and that Amgen should be bought on any weakness today following the data. AMGN-510 "looks like a blockbuster drug," says Yee, who keeps a Buy rating on Amgen with a $235 price target.

TODAY'S FREE FLY STORIES

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SDC

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$10.48

-0.62 (-5.59%)

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SDC

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TPR

Tapestry

$24.69

-1.28 (-4.93%)

10:55
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PUBGY

Publicis

$0.00

(0.00%)

, DIS

Disney

$129.71

-0.37 (-0.28%)

10:54
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Periodicals
Disney splitting $3B media business with Publicis, Omnicom, Campaign reports »

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PUBGY

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$0.00

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DIS

Disney

$129.71

-0.37 (-0.28%)

OMC

Omnicom

$74.82

0.17 (0.23%)

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ALXN

Alexion

$99.63

0.37 (0.37%)

10:45
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Alexion call volume above normal and directionally bullish »

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WDC

Western Digital

$59.26

0.9 (1.54%)

, AAPL

Apple

$237.68

1.47 (0.62%)

10:39
10/14/19
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10:39
On The Fly
Western Digital rises as analyst says buy on rising flash prices »

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WDC

Western Digital

$59.26

0.9 (1.54%)

AAPL

Apple

$237.68

1.47 (0.62%)

STX

Seagate

$53.60

-0.2 (-0.37%)

03/08/13
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HUM

Humana

$264.13

-2.2 (-0.83%)

10:34
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10:34
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Humana among five MA plans selected for Florida Medicare retirees »

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EHTH

eHealth

$54.37

-1.61 (-2.88%)

10:29
10/14/19
10/14
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10:29
Recommendations
eHealth analyst commentary  »

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BHC

Bausch Health

$20.50

-0.12 (-0.58%)

10:25
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Bausch Health call volume above normal and directionally bullish »

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  • 04

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GNUS

Genius Brands

$0.83

0.06 (7.79%)

10:25
10/14/19
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Conference/Events
Genius Brands to host business news update conference call »

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  • 14

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Conference/Events
UBS technology analyst to hold an analyst/industry conference call »

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SDC

SmileDirectClub

$10.56

-0.54 (-4.86%)

10:20
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SmileDirectClub analyst commentary  »

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  • 12

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$NSD

NASDAQ Market Internals

$0.00

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NASDAQ market internals summary »

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$NYE

NYSE Market Internals

$0.00

(0.00%)

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NYSE market internals summary »

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WLL

Whiting Petroleum

$6.94

-0.5 (-6.72%)

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Whiting Petroleum put volume heavy and directionally bearish »

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PING

Ping Identity

$16.72

0.25 (1.52%)

, NVST

Envista

$27.55

-0.32 (-1.15%)

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PING

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NVST

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DDOG

Datadog

$36.25

0.58 (1.63%)

BYND

Beyond Meat

$125.99

-5.41 (-4.12%)

BE

Bloom Energy

$3.11

-0.055 (-1.74%)

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FAST

Fastenal

$35.95

-0.41 (-1.13%)

, AMCX

AMC Networks

$46.77

-1.65 (-3.41%)

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FAST

Fastenal

$35.95

-0.41 (-1.13%)

AMCX

AMC Networks

$46.77

-1.65 (-3.41%)

DAL

Delta Air Lines

$52.44

-0.5 (-0.94%)

TOL

Toll Brothers

$39.32

-0.17 (-0.43%)

CGC

Canopy Growth

$18.66

-0.76 (-3.91%)

HEXO

Hexo

$2.38

-0.155 (-6.11%)

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NKE

Nike

$94.70

0.8 (0.85%)

, WDC

Western Digital

$59.86

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NKE

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$94.70

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$59.86

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VAR

Varian Medical

$112.50

1.72 (1.55%)

XLNX

Xilinx

$96.70

0.52 (0.54%)

HPE

HP Enterprise

$14.77

0.42 (2.93%)

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LK

Luckin Coffee

$18.99

-0.025 (-0.13%)

10:05
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Options
Luckin Coffee call volume above normal and directionally bullish »

Bullish option flow…

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NVST

Envista

$27.55

-0.32 (-1.15%)

10:02
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EHTH

eHealth

$53.10

-2.88 (-5.14%)

10:01
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eHealth lower following cautious Off Wall Street mention »

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  • 24

    Oct

SAFM

Sanderson Farms

$148.68

-1.2 (-0.80%)

10:00
10/14/19
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Conference/Events
Sanderson Farms to host investor day »

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