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ALRN

Aileron Therapeutics

$0.83

-0.0198 (-2.32%)

, PFE

Pfizer

$36.22

0.43 (1.20%)

15:16
09/29/19
09/29
15:16
09/29/19
15:16

Aileron presents interim Phase 2a data for ALRN-6924, Pfizer's Palbociclib combo

Aileron Therapeutics (ALRN) announced the presentation of interim results from its ongoing Phase 2a clinical trial evaluating the combination of ALRN-6924 and Pfizer's (PFE) IBRANCE for the treatment of patients with tumors harboring wild-type p53 and MDM2 amplification or MDM2/CDK4 co-amplification at the 2019 Congress of the European Society for Medical Oncology. As of the data cutoff date of September 2, 2019, the trial had enrolled 26 patients. The reported safety results show that the combination has been very well-tolerated in the trial, with the most common non-hematological related adverse events grade less than or equal to2 being nausea and fatigue. Neutropenia was the only grade greater than or equal to3 hematological related AE occurring in greater than5% of patients, while grade greater than or equal to3 thrombocytopenia and leukopenia each were observed in only one patient. The preliminary analysis of activity in the 17 evaluable patients with liposarcoma showed a disease control rate of 88% and a median progression-free survival of 4.4 months with 53% censoring. No partial or complete responses have been observed. Patients who have had at least one post-baseline assessment and have MDM2-amplified, TP53-WT tumors were deemed evaluable. On the basis of these preliminary safety and efficacy results, the company expects that the first indication for the combination of ALRN-6924 and palbociclib may be MDM2-amplified sarcoma patients, for whom there exists a substantial unmet need across all lines of treatment for the estimated 15,000 patients worldwide diagnosed each year. In addition, these results have further encouraged the company to expand enrollment to a total of 35 patients in order to evaluate the combination on the treatment of other MDM2-amplified cancers. Aileron expects to announce a final data readout in the second quarter of 2020.

ALRN

Aileron Therapeutics

$0.83

-0.0198 (-2.32%)

PFE

Pfizer

$36.22

0.43 (1.20%)

  • 02

    Oct

  • 29

    Oct

ALRN Aileron Therapeutics
$0.83

-0.0198 (-2.32%)

03/11/19
HCWC
03/11/19
INITIATION
Target $7
HCWC
Buy
Aileron Therapeutics initiated with a Buy at H.C. Wainwright
H.C. Wainwright analyst Edward White started Aileron Therapeutics with a Buy rating and $7 price target. The analyst believes the company's lead drug candidate, ALRN-6924, offers a differentiated approach to p53 inhibition. Assuming positive data, ALRN-6924 in combination with Ara-C for second-line myelodysplastic syndrome could reach the market in 2024 and generate sales of $342M by 2028, White tell investors in a research note.
04/09/19
ADAM
04/09/19
NO CHANGE
Target $5
ADAM
Buy
Aileron Therapeutics price target lowered to $5 from $19 at Canaccord
Canaccord analyst John Newman maintained a buy rating on Aileron Therapeutics, saying he expects ALRN-6924 preliminary Phase II data in MDM2-amplified cancers during the fourth quarter, which could be a win for the company if positive. However, the analyst lowered his price target on Aileron to $5 from $9 based on the company shifting focus from its prior lead acute myeloid leukemia and peripheral t-cell lymphoma indications to MDM2-amplified cancers.
PFE Pfizer
$36.22

0.43 (1.20%)

08/28/19
08/28/19
UPGRADE

Fly Intel: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Papa John's (PZZA) upgraded to Buy from Hold at Stifel with analyst Chris O'Cull saying new CEO Rob Lynch's turnaround experience and marketing expertise improves the company's prospects of delivering positive same-restaurant-sales gains over the coming quarters. 2. Targa Resources (TRGP) upgraded to Strong Buy from Outperform at Raymond James with analyst J R Weston saying the recent selloff in the shares is overdone and makes Targa "inexpensive." 3. Livongo Health (LVGO) upgraded to Overweight from Equal Weight at Morgan Stanley with analyst Ricky Goldwasser saying after the recent selloff, Livongo shares are trading at a discount to peers. 4. Sea Limited (SE) upgraded to Buy from Outperform at CLSA with analyst Marcus Liu saying the 12% pullback in the shares post the company's Q2 results is overdone. 5. Pfizer (PFE) upgraded to Hold from Sell at DZ Bank. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
09/03/19
HCWC
09/03/19
NO CHANGE
Target $73
HCWC
Buy
uniQure has significant first mover advantage in Hem B, says H.C. Wainwright
After uniQure (QURE) announced it has completed enrollment in the HOPE-B registration study, H.C. Wainwright analyst Debjit Chattopadhyay said he now anticipates a likely commercial launch during the fourth quarter of 2021, which is ahead of his prior expectation for launch in the second half of 2022. He sees AMT-061 with a 12+ month lead to be the first commercially viable gene therapy for Hemophilia B and contends the "first mover advantage is likely to be significant," especially if the product's safety profile, established manufacturing, clinical outcomes and clinical lead are compelling enough for Pfizer (PFE) to have second thoughts for its "potentially inferior me-too program" for SPK-9001. Chattopadhyay keeps a Buy rating and $73 price target on uniQure shares.
09/04/19
COWN
09/04/19
NO CHANGE
Target $48
COWN
Outperform
Pfizer shares remain attractively valued, says Cowen
Cowen analyst Steve Scalia updated his Pfizer (PFE) model following Q2 results, the closing of the Glaxo (GSK) Consumer joint venture, and the announcement that its Upjohn business would be divested and combined with Mylan (MYL). The analyst lowered his estimates to reflect what is left at the company and despite his revision feels the shares remain attractively valued. Scalia reiterated his Outperform rating and $48 price target on Pfizer shares.
09/19/19
JPMS
09/19/19
NO CHANGE
Target $37
JPMS
Neutral
Pfizer price target lowered to $37 from $46 at JPMorgan
JPMorgan analyst Chris Schott lowered his price target for Pfizer (PFE) to $37 from $46 and keeps a Neutral rating on the shares. While the Mylan (MYL)/Upjohn transaction creates a smaller, innovation-driven biopharma business and increases the company's near-term growth prospects, Pfizer's multiple is ahead of itself with the remaining company trading near the top end of the major pharma valuation range, Schott tells investors in a research note. He points out that Pfizer is facing "another major patent cycle" post 2025.

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0.95 (1.86%)

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LMAT

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WE

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KOD

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ADVM

Adverum Biotechnologies

$5.29

0.11 (2.12%)

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ADVM

Adverum Biotechnologies

$5.29

0.11 (2.12%)

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$37.58

0.17 (0.45%)

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GOOG

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SPX

S&P 500

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AGN

Allergan

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LYFT

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LYFT

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$39.49

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$30.09

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GM

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MRK

Merck

$84.31

0.6 (0.72%)

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$131.35

2.32 (1.80%)

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MRK

Merck

$84.31

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JNJ

Johnson & Johnson

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HMTV

Hemisphere Media

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PFE

Pfizer

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0.31 (0.87%)

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CNCE

Concert Pharmaceuticals

$5.85

(0.00%)

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INCY

Incyte

$76.14

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