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ZYME

Zymeworks

$25.99

0.49 (1.92%)

15:21
09/29/19
09/29
15:21
09/29/19
15:21

Zymeworks announces updated data for HER2-Targeted Bispecific Antibody ZW25

Zymeworks announced updated data from the ongoing multi-center Phase 1 clinical trial evaluating ZW25 in patients with HER2-expressing solid tumors, including biliary tract cancer, colorectal cancer, gynecological cancers, and gastroesophageal adenocarcinoma, in a poster discussion presentation at the ESMO 2019 Congress. Based on the data from the ongoing Phase 1 study, Zymeworks has initiated a broad clinical development program for ZW25 in multiple HER2-expressing cancers. In addition to the Phase 2 BTC trial announced, Zymeworks is continuing to evaluate ZW25 as a potential treatment for patients with other HER2-expressing cancers, including CRC and gynecological cancers. For patients with HER2-expressing GEA, ZW25 is being developed as a first-line treatment in combination with standard of care chemotherapy. Zymeworks also plans to initiate a Phase 2 study of ZW25 in combination with a CDK4/6 inhibitor and hormone therapy in third-line HER2-expressing, HR-positive breast cancer. Data were reported from 58 patients diagnosed with HER2-expressing solid tumors other than breast cancer who received ZW25 at the recommended dose of either 10 mg/kg weekly or 20 mg/kg every other week. Patients had a median age of 61 years and received a median of four prior therapies. 32 patients received prior HER2-targeted therapies including 87% of GEA patients. Of all patients, 23 were diagnosed with GEA, 13 with CRC, nine with BTC, and 13 with other HER2-expressing cancers, including endometrial, ovarian, pancreatic, and salivary gland. At the time of data cut-off, 46 of 58 patients were response evaluable. Overall, the majority of patients experienced a decrease in their target lesions with a disease control rate of 72%, comprising 16 patients with partial responses and 17 with stable disease. The objective response rate in the six evaluable biliary tract cancer patients was 67%, with the majority of patients experiencing disease control greater than six months. In the 11 CRC and 19 GEA patients, the objective response rates were 36% and 32%, respectively. The overall median progression-free survival was 5.2 months, with 27 of the 58 total patients still on study at the time of data cut-off. Among all patients, ZW25 was well tolerated as an outpatient therapy. All treatment-related adverse events occurring in 10% or more of patients were Grade 1 or 2.

ZYME Zymeworks
$25.99

0.49 (1.92%)

07/18/19
DBAB
07/18/19
INITIATION
Target $34
DBAB
Buy
Zymeworks initiated with a Buy at Deutsche Bank
Deutsche Bank analyst Konstantinos Aprilakis started Zymeworks with a Buy rating and $34 price target. The analyst initiated coverage on eight smid-cap Biotechnology stocks in the oncology space.
08/27/19
SBSH
08/27/19
NO CHANGE
Target $49
SBSH
Buy
Zymeworks price target raised to $49 from $22 at Citi
Citi analyst Yigal Nochomovitz raised his price target for Zymeworks to $49 from $22 and keeps a Buy rating on the shares. Despite the shares rallying 70% year-to-date, investors need to pay closer attention to Zymeworks' HER2 antibody-drug-conjugate ZW49, Nochomovitz tells investors in a research note. The analyst believes Investors "need to identify promising assets ever earlier in the valuation cycle to consistently get an edge with a large enough position to matter." He believes believe ZW49 could be transformative for Zymeworks and that the company should be worth $2B, or his $49 per share price target.
08/30/19
STFL
08/30/19
INITIATION
Target $45
STFL
Buy
Zymeworks initiated with a Buy at Stifel
Stifel analyst Stephen Willey started Zymeworks with a Buy rating and $45 price target. After successfully leveraging its core antibody engineering platform technologies to generate multiple strategic collaborations and develop two mostly wholly-owned clinical candidates, Zymeworks is now approaching a number of clinical inflection points and appears "poised for meaningful value creation," Willey tells investors in a research note. He believes W25/ZW49 are unique assets within an "increasingly-crowded" development landscape of next-generation HER2- targeting agents.
08/30/19
08/30/19
INITIATION

Fly Intel: Top analyst initiations
Catch up on today's top analyst initiations with this list compiled by The Fly: 1. Orchard Therapeutics (ORTX) initiated with an Outperform at Oppenheimer. 2. Zymeworks (ZYME) initiated with a Buy at Stifel. 3. Modine Manufacturing (MOD) initiated with a Neutral at DA Davidson. 4. AMTD International (HKIB) initiated with a Buy at Loop Capital. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, Reference Link

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TNXP

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RLMD

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WAIR

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0.01 (0.09%)

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FOMX

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$3.15

-0.09 (-2.78%)

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